The estimation of multiple parameters is a ubiquitous requirement in many quantum metrology applications. However, achieving the ultimate precision limit, i.e., the quantum Cramér-Rao bound, becomes challenging in these scenarios compared to single parameter estimation. To address this issue, optimizing the parameters encoding strategies with the aid of antiunitary symmetry is a novel and comprehensive approach. For demonstration, we propose two types of quantum statistical models exhibiting antiunitary symmetry in experiments. The results showcase the simultaneous achievement of ultimate precision for multiple parameters without any trade-off and the precision is improved at least twice compared to conventional encoding strategies. Our work emphasizes the significant potential of antiunitary symmetry in addressing multiparameter estimation problems.
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