Nanotechnology has been applied in construction to enhance the mechanical properties of concrete by using nanomaterials. A new stiffening scheme called catty-cornered propped concrete-filled steel tube (CFDST) column was proposed and analyzed under axial compression. The steel tube of CFDST specimens was filled with normal and nano material-based concrete, including nano-silica (NS), carbon nanotubes (CNT), and nano-titanium dioxide (NT). The study collected data on ultimate capacity, load vs strain behavior, and load vs deformation response, as well as ductility index (DI), secant stiffness, composite interaction, and confining effect variation. The results showed that the proposed stiffening scheme increased the ultimate capacity of unstiffened CFDST by approximately 14%, and the use of nanomaterials in CFDST infill concrete resulted in an approximately 7% increase in load capacity. Increasing the number of stiffening bars improved the ductility and stiffness of the column section, while the inclusion of nanomaterials decreased the ductility index and improved the stiffness of the section. The proposed stiffening scheme resulted in better composite interaction and increased confinement. The study concluded that the utilization of nanomaterial-based concrete as an infill in the stiffened CFDST column could enhance its performance under axial compression loading.