Ulcerative Endocarditis Research Articles

Сombination of ulcerative colitis and infectious endocarditis

The article presents a clinical case of a combination of ulcerative colitis and infectious endocarditis of the bicuspid aortic valve. The presence of such a combination is very difficult for the curation, primarily due to the high risk of complications associated with the peculiarities of specific therapy of these diseases and significantly affect the quality of life and prognosis. It is obvious that there is a need to accumulate knowledge about the development and course of cardiovascular diseases in patients with ulcerative colitis and to clarify the pathophysiological mechanisms of such conditions.

Medicine 100 Years Ago

IN THE 1880s the aristocrat of medical journals was undoubtedlyThe American Journal of Medical Sciences(founded in 1827). A quarterly, with about 300 octavo pages per issue, it was easily the most scholarly medical periodical in the United States. The contributors included leading British as well as American physicians and surgeons. Publication was prompt, and there was liberal compensation for articles used. Each issue had about ten original communications. Some dealt in depth with clinical conditions, others with various aspects of the preclinical sciences. Much experimental work was included. In a single issue the papers would range from an experimental study of ulcerative endocarditis to pancreatic surgery to a clinical study of cerebral localization. Much of the journal was devoted to long, critical, and analytic book reviews that were usually superbly informative. At least 90 pages per issue were given to a systematic survey of current literature, arranged in

Anaerobes isolated from ulcerative endocarditis and purulent pericarditis of cattle and swine (author's transl)

Bacteriological studies were performed on 11 bovine and 19 swine cases ofulcerative endocarditis and purulent pericarditis detected at post-mortem inspection.Anaerobes were isolated from lesions of hearts of 3 bovine and 3 swine cases. These isolateswere Peptostreptococcus intermedius (1 case), Peptostreptococcus anaerobius (2 cases), Bifidobacterium longum (1 case), Fusobacterium gonidiaformans (1 case), Fusobacteriumnecrophorum (1 case) and Eubacteriurn sp. (1 case). Veillonella parvula (1 case) andPeptococcus asaccharolyticus (1 case) were isolated from other specimens.

Acute Aortic Regurgitation and Abscess of Sinus of Valsalva Due to Fulminating Ulcerative Endocarditis

Acute aortic regurgitation due to ulcerative endocarditis developed in 3 children aged 10, 6, and 7 years, respectively. All had congenital aortic valve lesions. Intractable congestive heart failure ensued about 2 weeks, 1 week, and a few days, respectively, after onset of infection. Two patients were operated on in the acute stage, and in both, perivalvular spread of the infection was found with abscess formation of the right sinus of Valsalva perforating through the interventricular septum to the right ventricle; valve replacement and repair were performed, but both patients died. The correct diagnosis was missed in the third patient, who was thought to have myocarditis and who died one week after onset of infection: at autopsy a perforation of a bicuspid aortic valve and an aneurysm of the sinus of Valsalva were found.

Double valve replacement after staphylococcal endocarditis

THE incidence of bacterial endocarditis and its attendant mortality have undoubtedly been reduced since the introduction of antibiotics (Williams, Viroslav and Knight, 1970). The proportion of more virulent organisms is, however, increasing. The staphylococcus aureus is the most common of these and often causes ulcerative endocarditis of previously healthy valves (Quinn, Cox and Drake, 1966; British Medical Journal, 1969; Somers et al., 1972). Acute bacterial endocarditis of the aortic and mitral valves may produce cardiac failure that is not amenable to medical management. The sudden development of aortic incompetence is poorly tolerated and carries a particularly high mortality (Wise et al., 1971). Urgent repair or replacement of one or both valves may become necessary and is often life saving. There have been several reports of valve replacement for acute aortic incompetence after bacterial endocarditis (Wallace, Young and Osterhout, 1965; Windsor and Shanahan, 1967; Wise et al., 1971) but few after acute mitral incompetence (Robicsek et al., 1967; Yacoub et al., 1972; English, Honey and Clelland, 1972). Urgent double valve replacement after acute bacterial endocarditis is, however, rare (Windsor and Shanahan, 1967; Kretschmer and Lawrence, 1969; Gonzalez-Lavin, Wise and Ross, 1971). It is thus thought worthwhile reporting the following case.

Infective endocarditis: a changing disease. II.

I have chosen for the subject of this Croonian lecture in fective endocarditis in its subacute or chronic forms and have reverted to the original term rather than bacterial en docarditis as the disease may also be caused by rickettsiae, histoplasmas, fungi, and possibly viruses. This disease, al though not common, has always had a fascination for the clinician, morbid anatomist, and bacteriologist, and I can not do better than follow the precept of Osier,1 who, in his Goulstonian lecture on malignant endocarditis to the College in 1885, stated: is of use from time to time to take stock, so to speak, of our knowledge of a particular disease, to see exactly where we stand in regard to it, and to inquire to what conclusions the accumulated facts seem to point, and to ascertain in what direction we may look for fruitful investi gations in the future. Before this there were many descrip tions in the literature of vegetative or ulcerative endocardi tis, but Osier first showed clearly that these cases could be separated into two groups?septic endocarditis, which we now call acute, where there was an obvious septic focus with septicaemia and infected infarcts, and so-called primary en docarditis, where the source of infection was not obvious, infarcts did not suppurate, and the disease ran a more chronic course. Between 1885 and 1909 the infective nature of this type of chronic endocarditis was established with recovery of or ganisms, usually streptococci of low virulence, from the vegetations and blood stream, and it was realized that the disease affected patients with either chronic valvular disease or congenital malformations of the heart. The clinical fea tures of the disease also became better recognized and were reviewed by Glynn2 in his Lumleian lectures of 1903.

Infective endocarditis: a changing disease. I.

I have chosen for the subject of this Croonian lecture in fective endocarditis in its subacute or chronic forms and have reverted to the original term rather than bacterial en docarditis as the disease may also be caused by rickettsiae, histoplasmas, fungi, and possibly viruses. This disease, al though not common, has always had a fascination for the clinician, morbid anatomist, and bacteriologist, and I can not do better than follow the precept of Osier,1 who, in his Goulstonian lecture on malignant endocarditis to the College in 1885, stated: "it is of use from time to time to take stock, so to speak, of our knowledge of a particular disease, to see exactly where we stand in regard to it, and to inquire to what conclusions the accumulated facts seem to point, and to ascertain in what direction we may look for fruitful investi gations in the future." Before this there were many descrip tions in the literature of vegetative or ulcerative endocardi tis, but Osier first showed clearly that these cases could be separated into two groups?septic endocarditis, which we now call acute, where there was an obvious septic focus with septicaemia and infected infarcts, and so-called primary en docarditis, where the source of infection was not obvious, infarcts did not suppurate, and the disease ran a more chronic course. Between 1885 and 1909 the infective nature of this type of chronic endocarditis was established with recovery of or ganisms, usually streptococci of low virulence, from the vegetations and blood stream, and it was realized that the disease affected patients with either chronic valvular disease or congenital malformations of the heart. The clinical fea tures of the disease also became better recognized and were reviewed by Glynn2 in his Lumleian lectures of 1903.

Anton Weichselbaum on the etiology of acute endocarditis-1885

During the last 30 years of the 19th century, lesions of the heart valves, infected and uninfected, were under active study in the clinics and pathologic institutes of central Europe. Some of the writings that record the advance of knowledge in this field have been discussed in the last few volumes of this Journal. Ulcerative (later called bacterial) endocarditis became the subject of controversy between the great Rudolf Virchow and the lesser Karl Koester. The details are given in a thesis by Virchow’s pupil Joseph Hamburg,l which was recently discussed in the present historical series.* To the same controversy a brief and interesting contribution was made by the eminent Anton Weichselbaum (1845 to 1920). Early in his career Weichselbaum served as physician and prosector in the Austro-Hungarian army. In 1885 he became professor of pathologic histology and bacteriology at the University of Vienna. Eight years later he attained the important post of Professor Ordinarius of Pathological Anatomy at the same university. Although he made highly esteemed contributions to oncology and to knowledge of diabetes, his name is now remembered mainly in connection with the infectious diseases, especially meningitis, pneumococcus infections and tuberculosis. The Diplococcus intracellularis meningitidis was so named by him in 1887 but for a long time was designated informally as Weichselbaum’s meningococcus. Actually his importance far transcended these contributions, since he was one of the first to recognize the importance of bacteriology to pathology and to public health. He is given much credit also for the high rank that public health attained in Austria during his active years.3 The essay that is now to be considered exemplifies Weichselbaum’s interest in infection. It is titled, “Zur Aetiologie der akuten Endokarditis” (“On the Etiology of Acute Endocarditis”) and was published in the Wiener Medizinische Wochenschrift.4

Clubbing of the fingers in sarcoidosis.

To the Editor.— Clubbing of the fingers occurs frequently in a wide variety of unrelated cardiopulmonary disorders including bronchiectasis, lung abscess, bronchial carcinoma, congenital heart disease, arteriovenous aneurysm, and interstitial fibrosis. It occurs less frequently in ulcerative colitis, liver disease, bacterial endocarditis, and carcinoma of esophagus and stomach. 1 Clubbing has not been reported in sarcoidosis. 2 Of 136 patients with histologically proven sarcoidosis followed-up at Los Angeles County—University of Southern California, we have recently studied four who also had marked clubbing of the fingers: two patients had clubbing at the time of initial presentation and the other two developed clubbing during the follow-up period. All four patients had radiological evidence of bilateral interstitial disease (Table). Finger clubbing is a common feature with an incidence of 70% to 90% of patients having fibrosing alveolitis [diffuse interstitial fibrosis, (DIF)]. 3,4 Patients with sarcoidosis may present with radiological features that are indistinguishable

Congenital saccular aneurvsms of the aortic ring.

Congenital saccular aneurysms arising in the area of the aortic ring are not common. They may be located deep in the aortic sinus, at the commissure of two adjacent cusps, or in the area involving the membranous portion of the interventricular septum. They may be found at any age. This report concerns a child 2 years of age with a relatively large saccular aneurysm of the aortic ring just at the site of the commissure between the right and noncoronary cusps of the aortic valve. Terminally, this anomaly was complicated by infection leading to vegetative and ulcerative endocarditis. Death was sudden and was apparently directly related to the complications of the deformity.

Right-sided ulcerative endocarditis recognized ante mortem

Right-sided ulcerative endocarditis recognized ante mortem

Abscess of the heart: a complication of acute vegetative and ulcerative endocarditis.

At autopsy we encountered a large abscess of the interatrial septum as a complication of acute vegetative and ulcerative endocarditis, which was probably bacterial. The abscess was connected by a fistula to the aorta and furthermore had ruptured into the left atrium. A search of the literature failed to disclose a similar lesion.

Salmonella subacute bacterial endocarditis.

Case Reports1 January 1956SALMONELLA SUBACUTE BACTERIAL ENDOCARDITISMAURICE RICH, M.D., F.A.C.P., EDWARD ST. MARY, M.D.MAURICE RICH, M.D., F.A.C.P.Search for more papers by this author, EDWARD ST. MARY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-162 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrganisms of the Salmonella group rarely produce bacterial endocarditis.1 Perusal of the literature from 1929 reveals 24 published cases, only two of which did not terminate fatally. A variety of organisms of the Salmonella species has been isolated from these 24 cases. Salmonella choleraesuis has been cultured in 13 of this group,2 indicating the highly invasive character of this organism.The following report of subacute bacterial endocarditis due to S. choleraesuis von Kunzendorf represents the third nonfatal case published.CASE REPORTHistory:A 30 year old white male was admitted to the Mount Sinai Hospital of Greater Miami on July...Bibliography1. Jones M: Subacute bacterial endocarditis of non-streptococcic etiology, Am. Heart J. 40: 106, 1950. CrossrefMedlineGoogle Scholar2. Saphra I: Fatalities in Salmonella infections, Am. J. M. Sc. 220: 74, 1950. CrossrefMedlineGoogle Scholar3. Read CT: Endocarditis caused by Salmonella suipestifer , J. Infect. Dis. 65: 263, 1939. CrossrefGoogle Scholar4. Forster DE: Fatal bacterial endocarditis due to Salmonella suipestifer , Am. J. M. Sc. 197: 234, 1939. CrossrefGoogle Scholar5. GoulderKingslandJaneway NEMFCA: Salmonella suipestifer infection in Boston: report of 11 cases with autopsy findings in a case of bacterial endocarditis due to this organism, and a study of the agglutination reactions in this infection, New England J. Med. 226: 127, 1942. CrossrefGoogle Scholar6. TenBroeckLiYii CCPH: Studies in paratyphoid C bacilli isolated in China, J. Exper. Med. 53: 699, 1934. Google Scholar7. GouleyIsrael BASL: Salmonella suipestifer bacteremia with acute endocarditis, Arch. Int. Med. 53: 697, 1934. CrossrefGoogle Scholar8. StumpeBaroody ARHB: Salmonella endocarditis, Arch. Int. Med. 88: 679, 1951. CrossrefGoogle Scholar9. Weller C: Bacteremia due to Salmonella choleraesuis, variety Kunzendorf (paratyphoid C), complicated by ruptured aortic aneurysm, New York State J. Med. 52: 1055, 1952. Google Scholar10. MeyerHowell JK: Acute endocarditis caused by Bacillus paratyphosus B, Arch. Path. 26: 368, 1938. Google Scholar11. Wells HG: Acute endocarditis produced by Bacillus paratyphosus B, Arch. Path. 23: 270, 1937. Google Scholar12. DeSwiet J: Subacute bacterial endocarditis due to Salmonella typhimurium , Brit. M. J. 2: 1155, 1949. CrossrefMedlineGoogle Scholar13. GalbreathHull WRE: Sulfonamide therapy of bacterial endocarditis: results in 42 cases, Ann. Int. Med. 18: 201, 1943. LinkGoogle Scholar14. AndersonAndersonTaylor ESHJJ: New Salmonella (Salmonella fayed) which caused fatal endocarditis in man, J. Path. and Bact. 59: 533, 1947. CrossrefMedlineGoogle Scholar15. KurzCrehanThomson EEC: Salmonella endocarditis with streptomycin failure, Ann. Int. Med. 31: 497, 1949. LinkGoogle Scholar16. WallHobbs NMRE: Acute ulcerative endocarditis with overwhelming septicemia due to Salmonella choleraesuis , Pennsylvania M. J. 56: 892, 1953. MedlineGoogle Scholar17. McFadzeanChi-To AJH: Bacterial endocarditis due to Salmonella sp. (type sendai) with recovery, Arch. Int. Med. 90: 858, 1952. CrossrefGoogle Scholar18. WoodwardSmadelLeyGreenMankikar TEJEHLRDS: Preliminary report on beneficial effect of Chloromycetin in treatment of typhoid fever, Ann. Int. Med. 20: 131, 1948. Google Scholar19. RossBurkeRiceWashingtonStevens SFGECJAS: Chloromycetin in the treatment of Salmonella enteritis, New England J. Med. 242: 173, 1950. CrossrefMedlineGoogle Scholar20. KingLewisWelchClarkJohnsonLyonsScottCornely EQCNHEAJBJBRBPB: Clinical observations on the use of Terramycin hydrochloride, J. A. M. A. 143: 1, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami, Florida*Received for publication November 5, 1954.From the Department of Internal Medicine, Mt. Sinai Hospital of Greater Miami, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProsthetic Valve Endocarditis Diagnosed Because of Persistent Hemolytic Anemia After Salmonella Iliopsoas Abscess TreatmentInfective endocarditis caused by gram-negative bacteria: A review of the literature, 1945–1977Infective endocarditis—1973Treatment of infective endocarditis—1973Salmonella endocarditis complicated by a myocardial abscessEtiology of BacteremiaMycotic aneurysm and endocarditisInfective Endocarditis in the Antibiotic EraSalmonella infantis infection of a pre-existent ventricular aneurysmBacterial endocarditis due to salmonella typhimuriumErkrankungen des Endokard 1 January 1956Volume 44, Issue 1Page: 162-166KeywordsAnemiaAttentionChloramphenicolEndocarditisHospital medicineLesionsSalmonellaSepsis ePublished: 1 December 2008 Issue Published: 1 January 1956 PDF downloadLoading ...

Rupture of spleen in subacute bacterial endocarditis: mycotic aneurysm of splenic artery and spontaneous rupture of spleen in subacute bacterial endocarditis.

THE ASSOCIATION of bacterial endocarditis and aneurysm has been recognized for over a century. In 1851, Koch1described a patient with endocarditis who died suddenly after rupture of a superior mesenteric artery aneurysm. Tufnell2recognized the influence of emboli from valvular vegetations in the development of arterial aneurysms. Osler3termed these emboli mycotic and postulated the significant role of micro-organisms in the production of such aneurysms. In his Gulstonian Lecture on Malignant Endocarditis,4Osier described a case of ulcerative endocarditis, with multiple small aneurysms involving the aortic arch. In 1887, Eppinger5demonstrated the actual infectious nature of the emboli, applying careful bacteriologic techniques. We are reporting a patient who recovered from subacute bacterial endocarditis complicated by a ruptured aneurysm of the splenic artery and rupture of the spleen. REPORT OF A CASE V. C., 401163, a 30-year-old white housewife, was admitted to the Research and Educational Hospital on March

A case of infection with brucella sius, causing endocarditis and nephritis; Death from rupture of mycotic aneurysm

The case of a man with Br. suis bacteriemia is reported. The infection lasted approximately two hundred days, during which endocarditis and nephritis developed. He recovered from uremia, only to succumb to rupture of a mycotic aneurysm of the left femoral artery. Sulfonamide therapy and the administration of convalescent serum failed to influence the infection. The pooled serum was prepared from the blood of donors who had recovered from Br. suis bacteriemia. Anatomic studies after death revealed, among other things, ulceration and vegetations on a previously normal mitral valve. The specific nature of the lesions was proved, during life, by the repeated isolation of Br. suis in pure culture from the blood stream, and, after death, by obtaining pure cultures of Br. suis from the vegetations from the endocardium, the walls of the mycotic aneurysm, and other tissues. The blood contained specific agglutinins, but the skin did not react to brucellergin intradermally. So far as we are aware, this is the first reported case in which ulcerative endocarditis has been proved, beyond doubt, to be due to Br. suis. It is the second reported instance in which rupture of a mycotic aneurysm due to Br. suis has caused death.

Hodgkin's Disease; Vegetative and Ulcerative Endocarditis: Clinical and Pathological Conferences at Cook County Hospital

Hodgkin's Disease; Vegetative and Ulcerative Endocarditis: Clinical and Pathological Conferences at Cook County Hospital

Coronary embolism: Report of three cases

Three cases of coronary embolism were encountered among 12,300 consecutive autopsies at Cleveland City Hospital. In none was the diagnosis made clinically. The source of the emboli in each instance was an ulcerative endocarditis of either the aortic or mitral valves. Myocardial infarction occurred in two cases.

SUBACUTE BACTERIAL ENDOCARDITIS COMPLICATED BY PREGNANCY

There have been frequent reports in the literature of cases of subacute bacterial endocarditis occurring during the puerperium, yet there have been few bona fide cases of the disease observed during pregnancy. Walser 1 recently published a fairly exhaustive review of the literature and was able to find only two unquestioned examples of endocarditis lenta associated with pregnancy, to which he added two cases. He found that true malignant or ulcerative endocarditis had been reported not infrequently, beginning with the case of Litten's 2 in 1878. The textbooks make no mention of the condition in pregnancy, and in extensive series of cases, such as those reported by Libman 3 and Blumer, 4 there is no reference to any case complicated by pregnancy. Libman 5 infers in one article that cases of bacterial endocarditis of the puerperium may be the result of an old infection present before delivery and not of

Vegetative endocarditis due to the Brucella melitensis: With a case report

A case of undulant (Malta) fever due to the Brucella melitensis, variety melitensis A, associated with a vegetative and ulcerative endocarditis of the aortic valves, and which clinically presented the manifestations of subacute bacterial (infective) endocarditis, is reported.

Ulcerative Endocarditis of the Pulmonic Cusps*

Article1 January 1929Ulcerative Endocarditis of the Pulmonic CuspsCase ReportEDWARD WEISS, M.D.EDWARD WEISS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-7-665 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptL. S., a colored woman of 34, was admitted to the Jefferson Hospital in the service of Dr. Thomas McCrae, January 24, 1928.She complained of pain in the right chest, chills, cough and expectoration. The family history was negative. The past history was unimportant. The patient had one son nine years old and had three miscarriages prior to the birth of her son.The history of the present illness was not quite clear. Apparently it began late at night on January 18, with pain in the right chest posteriorly, but there was some history of two attacks of chills... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*From the Department of Medicine, Jefferson Medical College Hospital, Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1929Volume 2, Issue 7Page: 665-666KeywordsBirthEndocarditisHospital medicineMiscarriageThorax Issue Published: 1 January 1929 PDF DownloadLoading ...