U-shaped Relationship Research Articles

Curvilinear effect of policy intensity on innovation performance in the integrated circuit industry: Too much of a good thing?

The improvement of innovation performance is critical to the high-quality development of the integrated circuit industry. Regional innovation cannot be delivered and sustained without the help of governments. This paper uses negative binomial regression to investigate the quadratic relationship between policy intensity and innovation performance in the integrated circuit industry at the city level and reveals how network centrality moderates this relationship. The results are given as follows. First, policy intensity exhibits an inverted U-shaped relationship with innovation performance. Second, after network centrality is introduced, the relationship between policy intensity and innovation performance shows a shape-flip from inverted U-shaped in low network centrality to U-shaped in high network centrality. Third, compared with exploitative innovation performance, exploratory innovation performance is more sensitive to policy intensity and needs higher network centrality to change the link from an inverted U-shaped to a U-shaped relationship. This research reveals the importance of incorporating cooperation into the interactive framework between policy and innovation, which provides guidance for fostering innovation in the global integrated circuit industry.

The impact of antiretroviral treatment and child-focused unconditional cash transfers on child mortality.

Although there is sufficient evidence in the epidemiological literature that antiretroviral treatment (ART) reduces child mortality, there is limited evidence of its effect in the socio-economic determinants of child mortality literature. Furthermore, evidence on the effect of child focused unconditional cash transfers (UCTs) on child mortality is limited, especially in the African context. Using South Africa's provincial level data over the period 2001 to 2019, we evaluate the effect of ART and child focused UCTs on child mortality. We use the two-stage instrumental variable mean group estimator. We find that ART reduces child mortality. Moreover, we find an inverted U-shaped non-linear relationship between UCTs and child mortality that is contingent to the level of cash transfer coverage. Our analyses also reveal that UCTs improve the effect of ART on child mortality by enhancing access and adherence to treatment. While the focus of our analyses was on the child mortality effects of ART and UCTs, our findings reaffirm the well-documented impacts of factors such as public health expenditure, HIV/AIDS, female education, and health worker density on child mortality. Collectively, the combination of high ART and UCTs coverage, increased public health expenditure, enhanced female education, and improved health worker density, represents value for money for policymakers and funders. These areas should be prioritised to improve child well-being.

Symptom-to-balloon time and risk of ventricular arrhythmias in patients with STEMI undergoing percutaneous coronary intervention: the VERY-STEMI study

BackgroundVentricular arrhythmias (VAs) mainly occur in the early post-myocardial infarction (MI) period. However, studies examining the association between total myocardial ischemia time interval and the risk of new-onset VAs during a long-term follow-up are scarce. MethodsThis study (symptom-to-balloon time and VEntricular aRrhYthmias in patients with STEMI, VERY-STEMI study) was a multicenter, observational cohort and real-world study, which included patients with ST-segment elevation MI (STEMI) undergoing percutaneous coronary intervention (PCI). The primary endpoint was cumulative new-onset VAs during follow-up. The secondary endpoints were the major adverse cardiovascular events (MACE) and changes in left ventricular ejection fraction (ΔLVEF, %). ResultsA total of 517 patients with STEMI were included and 236 primary endpoint events occurred. After multivariable adjustments, compared to patients with S2BT of 24h-7d, those with S2BT≤24h and S2BT>7d had a lower risk of primary endpoint. RCS showed an inverted U-shaped relationship between S2BT and the primary endpoint, with an S2BT of 68.4h at the inflection point. Patients with S2BT≤24h were associated with a lower risk of MACE and a 4.44 increase in LVEF, while there was no significant difference in MACE and LVEF change between the S2BT>7d group and S2BT of 24h-7d group. ConclusionsS2BT of 24h-7d in STEMI patients was associated with a higher risk of VAs during follow-up. There was an inverted U-shaped relationship between S2BT and VAs, with the highest risk at an S2BT of 68.4h.

The impact of the Seller's facial image on consumer purchase behavior in peer-to-peer accommodation platforms

Consumers' initial impressions of a seller's facial appearance play a crucial role in influencing purchase behavior. However, the underlying mechanisms by which a seller's facial appearance influences consumer purchase behavior remain unexplored. This study adopted a multimethod approach to explore these questions. First, drawing on the profile pictures of 1240 sellers from the Airbnb peer-to-peer accommodation platform, we investigated the impact of two principal facial attributes (facial attractiveness and facial expressions) on the formation of consumers' initial impressions and their subsequent influence on purchase decisions. Second, we explored the underlying mechanisms through two online experiments. Our findings indicate a U-shaped relationship between sellers' facial attractiveness and consumer purchase behavior. Additionally, we found that facial expressions such as happy, surprise, and sad, influence consumer purchase behavior positively in comparison to neutral expressions. Furthermore, our study demonstrates that the purchase price acts as a moderator of the U-shaped effect of facial attractiveness on consumer purchase behavior, while text sentiment intensity serves as a negative moderator of the impact of facial expressions of consumer purchase behavior. Finally, the study elucidates the influence mechanism of facial attractiveness and facial expressions on consumers' purchasing decisions. These insights provide novel perspectives on the role of sellers' facial attributes and offer valuable references for devising effective marketing strategies and optimizing platform operational services related to the design of seller facial imagery.

The authenticity perception of a heritage sporting event: a comparison between residents and non-residents

ABSTRACT Purpose This study explored authenticity perceptions in a heritage sporting event, comparing residents and non-residents (i.e. international tourists) using consumption capital theory. Methodology Focusing on Sumo wrestling in Japan, data were collected from 845 Japanese residents through an online survey and 245 non-residents via an on-site survey at the Ground Sumo Tournament in Tokyo. Findings Mann–Whitney’s U test revealed that non-residents perceive greater authenticity than residents. Ordinary Least Square regression analyses examined different factors influencing authenticity perceptions between residents and non-residents. Residents’ prior knowledge significantly affected their perceived authenticity, displaying a U-shaped curve, while non-residents’ did not. Past experience did not impact authenticity perceptions for either group. Additionally, this study highlighted the impacts of consumer demographics on authenticity perceptions. Practical Implication Including residents in tourism commodification process of sport heritage events is stressed to prevent tourists’ misunderstanding of destinations. Research Contribution Our findings contribute to applying consumption capital theory in sport heritage tourism. The observed U-shaped relationship between residents’ prior knowledge and authenticity perception provides empirical support, aligning with suggestions for a non-linear relationship based on the law of diminishing marginal utility. Originality The results stimulate discussions on sport and tourism development within sport heritage, extending to UNESCO’s Traditional Sports and Games initiative.

The spatial spillover effect of green technology innovation on water pollution–evidence from 283 Chinese cities

While economic development brings serious environmental problems, technological advances can effectively reduce pollution, which helps to achieve the Sustainable Development Goals. Although the impact of green technology innovation on atmospheric pollutants and carbon emissions has been extensively studied, the effect of such innovation on pollutant reduction varies due to the diverse regional distribution characteristics of different pollutants. Thus, this paper contributes to the literature by examining the influence of green technology innovation on water pollution from a regional perspective, with a particular emphasis on the pronounced clustering of wastewater pollution in China's coastal areas. Both Fixed-Effect model and spatial analysis are adopted. Our findings reveal a significant U-shaped relationship between technology innovation and water pollution, as measured by both industrial wastewater and the ratio of unprocessed sewage. Interestingly, this pollution reduction effect also exhibits a U-shaped spatial spillover. Given the rapid development of the digital economy, it can further amplify the spatial spillover effect of green innovation, especially in eastern regions. This study also provides recent empirical evidence from China to the Environmental Kuznets Curve.

The curvilinear relationship between governance structure and nonfinancial risk disclosure in Saudi Arabian firms: do ethical values matter?

Purpose The purpose of this paper is to examine the possibility of a curvilinear relationship between governance structure and nonfinancial risk disclosure. This paper also examines the moderating role of ethical values on the governance structure and nonfinancial risk disclosure relationship. Design/methodology/approach The sample of this paper contains 71 nonfinancial firms listed on the Saudi Stock Exchange from 2013 to 2020 (568 firm-year observations). The authors use OLS regressions to test the hypotheses. Findings The authors find there is a U-shaped relationship between governance structure and nonfinancial risk disclosure. Moreover, they show that ethical values moderate the relationship between governance structure and nonfinancial risk disclosure. Research limitations/implications The findings of this study offer implications for policy makers and firm managers in Saudi Arabia which there should periodically assess and adapt their governance frameworks due to potential fluctuations in the optimal level resulting from internal or external disruptions. Originality/value To the best of the authors’ knowledge, this is the first study in Saudi Arabia that provides new empirical evidence on the curvilinear relationship between governance structure and nonfinancial risk disclosure and the moderating role of ethical values on this relationship.

Exploiting cognitive distance for enhanced innovative capabilities: The role of collaboration controls in incumbent-startup partnerships

Collaborations between incumbent and startup firms are hailed for enhancing incumbent innovation capability. Yet, these collaborations often face challenges, notably cognitive distance, highlighting the need to balance potential novelty and mutual understanding between partner firms. Drawing on prior research that indicates a non-linear relationship between cognitive distance and innovation outcomes, we focus on collaboration controls—tools and practices that guide and motivate managers responsible for startup collaborations— serving as critical mechanisms for incumbents to exploit cognitive distance. We hypothesize that the use of collaboration controls mediates the non-linear relationship between cognitive distance and realizing enhanced innovation capabilities. Empirical findings from a survey of 239 French incumbents confirm an inverted U-shaped relation between cognitive distance and enhanced innovative capabilities. Notably, we find that use of collaboration controls mediates this relationship, highlighting the importance of controls in exploiting cognitive distance. This research contributes to unveiling the intricacies of successful collaborations between incumbents and startups by uncovering a critical role for collaboration controls in realizing novelty potential.

The U-shaped relationship between corruption and international tourism demand: A gravity model approach

The tourism industry significantly contributes to a country’s economic growth and creates a positive image of the destination. This study assesses the impact of corruption on international tourism demand. It employs two-dimensional analyses using the gravity model and a pooled ordinary least square estimator to provide a unique recognition of international tourism demand. The study utilized a conditional quantile regression technique to analyze a dataset of 200 destination countries from 1995 to 2022. The empirical results demonstrate a mixed effect of corruption on international tourism demand. The analysis reveals a non-linear relationship between corruption and international tourism demand, with the inverted-U relationship being statistically significant only at the 50th–75th quantiles and not holding at the upper and lower quantiles. The research confirms that income has a positive impact on tourism across quantiles, but the impact is disproportionate. The sub-period of 2006–2022 experienced a significant decline in gross domestic product (GDP) due to the global financial crisis and its aftershocks, which severely impacted the attractiveness of destination countries for tourists. These valuable insights can inform national tourism policies and businesses.

#2477 Longitudinal serum bicarbonate and mortality risk in older patients with advanced chronic kidney disease: analyses from the EQUAL cohort

Abstract Background and Aims Serum bicarbonate (SBC) disorders have been consistently linked to mortality in chronic kidney disease (CKD) patients. Low SBC levels have been extensively associated with increased mortality in CKD patients, possibly due to the detrimental effects of acidosis on various organs and systems. Likewise, several studies have identified high levels of SBC as a risk factor for mortality in the CKD population. To date, most studies have focused on the association between SBC levels and patient survival during the pre-kidney replacement therapy (KRT) period or the period after KRT initiation, considered separately. None have explored this association across the continuum of CKD (e.g., from pre-KRT to post-KRT start), which is relevant since metabolic acidosis is expected to be managed through dialysis in the KRT population, and thus its clinical outcomes might change after KRT initiation. To provide new insights on this topic, we aimed to explore the relationship between SBC and mortality in advanced CKD during three distinct treatment periods: during the pre-KRT period, during the transition phase surrounding the start of KRT (transition-CKD), and during KRT. Method Using the European QUALity Study on treatment in advanced CKD (EQUAL) cohort, which includes patients aged ≥65 years and eGFR ≤20 ml/min per 1.73 m2 from six European countries, we explored the association between longitudinal SBC and all-cause mortality in three separate CKD populations: pre-KRT, transition-CKD and in the KRT populations, using multivariable time-dependent Cox regression models. The cumulative time-averaged, the cumulative exposure of SBC, and the slope of the SBC trajectory during the pre-KRT phase were calculated and evaluated for association with all-cause mortality in the transition-CKD population. Subgroup analysis were used to evaluate the effect modification by pre-specified variables on the relationship between SBC and mortality. Results We included 1485 patients with a median follow-up of 2.9 (IQR 2.7) years, during which 529 (35.6%) patients died. A U-shaped relationship between SBC levels and all-cause mortality was observed in the pre-KRT population (p = 0.03; Fig.). Low cumulative exposure, defined as the area under the SBC trajectory before KRT initiation, was associated with increased mortality risk after transitioning to KRT (p = 0.01). Similarly, in the KRT population, low SBC levels showed a trend towards increased mortality risk (p = 0.13). We observed effect modification on the relationship between SBC and mortality by subjective global assessment category (p-value for interaction = 0.02) and KRT initiation (p-value for interaction = 0.02). Conclusion Our study has provided important insights into the relationship between SBC and mortality in advanced CKD patients. A U-shaped relationship describes the association between SBC and mortality in the advanced CKD pre-KRT population, whereas in patients that initiate KRT only low SBC levels are associated with an increased mortality risk. Our findings suggest that the relationship between SBC and mortality varies across different stages of CKD and that this relationship is modified by KRT initiation. From this point of view, it would be appropriate to consider a personalized management of acid-base balance disorders based on a comprehensive evaluation of the clinical status of the patient.

Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007-2018.

The relationship between physical activity and hyperuricemia (HUA) remains inconsistent, and the dose-response association between moderate-to- vigorous physical activity (MVPA) level and HUA still unclear. In this study, we aimed to investigate the dose-response association of MVPA with HUA, and to explore an appropriate range of MVPA level for preventing HUA. Data from the US National Health and Nutrition Examination Survey (NHANES) 2007-2018 were used, including 28740 non-gout adult Americans. MVPA level was self-reported using the Global Physical Activity Questionnaire and serum uric acid was measured using timed endpoint method. The dose-response relationship between MVPA level and HUA was modeled with restricted cubic spline analysis. Logistic regression analysis were applied to estimate odd ratios (ORs) and 95% confidence intervals (CIs) of the relationships between MVPA level and HUA. A total of 28740 adults were included in the study (weighted mean age, 47.3 years; 46.5% men), with a prevalence rate of HUA was 17.6%. The restricted cubic spline functions depicted a general U-shaped relationship between MVPA level and HUA. The MVPA level of 933 and 3423 metabolic equivalent (MET) -min/wk were the cut-off discriminating for the risk of HUA. Participants with MVPA levels in the range of 933-3423 MET-min/wk had lower risk of HUA and they had the lowest risk when MVPA levels at around 1556 MET-min/wk. Compared with the moderate-activity group (600-2999 Met-min/wk), the low-activity group (< 600 Met-min/wk) had a greater risk of HUA (OR, 1.13 [95%CI, 1.02-1.26]) after fully adjusting for potential confounders. Compared with the moderate MVPA level, the low MVPA level was associated with the higher risk of HUA. And there may be a U-shaped dose-response relationship between MVPA level and HUA. When MVPA level was approximately 933-3423 MET-min/wk, the risk of HUA may at a lower level and the risk reached the lowest when MVPA level at around 1556 MET-min/wk.

#745 Age and gender specific reference values for renal volume and association with risk factors for chronic kidney disease in a general population

Abstract Background and Aims Renal volume (RV) is associated with renal function and with a variety of cardiovascular risk factors (CVRF). We analyzed RV by magnetic resonance imaging (MRI) in a large population-based study (Study of Health in Pomerania; SHIP-TREND) and tested the influence of age, sex, smoking status, BSA, systolic and diastolic blood pressure, type 2 diabetes, HDL-C, LDL-C, estimated glomerular filtration rate (eGFR) and uric acid on RV. Method 1,815 participants without kidney disease (930 women) aged 21-81 years were included in our study. Right and left RV with and without body surface area (BSA) indexation were compared among three age groups (22-39 years, 40-59 years, 60-81 years) by median and interquartile range and tested separately in women and men. Results eGFR, uric acid, right and left RV were higher in men compared to women (all p &amp;lt; 0.001). Left kidney were larger than right kidneys (both sexes). With age, RV showed a continuously decreasing trend in women and an upside down U-shape relation in men. In multivariable linear regression models, current smoking (β = 14.96, 95% CI 12.12; 17.79), BSA (β = 97.66, 95% CI 90.4; 104.93), diastolic blood pressure (β = 0.17, 95% CI 0.01; 0.32), and eGFR (β = 0.57, 95% CI 0.50; 0.65) were positively associated with both left and right renal volume whereas uric acid (β = −0.03, 95% CI −0.05; −0.01) showed an inverse association with RV. Interestingly, the same eGFR correlated with higher RV in men compared to women. Conclusion Reference values for RV are different for age-groups and sex. For any given age, female kidneys are smaller than male kidneys. RV associates positively with eGFR, but for any chosen eGFR, renal volume in females is lower compared to males. RV decreases with age, but in men, RV first increases in the age group 40-59 years before finally decreasing with a faster decline after 60 years. This may reflect hyperfiltration and glomerular hypertrophy associated with the presence of CVRF.

Spatial heterogeneity and driving mechanisms of carbon storage in the urban agglomeration within complex terrain: Multi-scale analyses under localized SSP-RCP narratives

Ecological carbon storage is critical to climate change mitigation by absorbing CO2 from the atmosphere. Mountainous ecosystems, crucial carbon reservoirs, are experiencing persistent carbon storage declines, yet management mechanisms targeting such complex terrains remain challenging. Focusing on the Sichuan-Chongqing urban agglomeration, interwoven as mountains and basins, we employed the MPI-coupled (Improved Markov-PLUS-InVEST) model and localized "socio-economic-climatic" narratives to simulate the dynamic evolution of carbon storage over extended periods. Diverse impacts and gradient effects of social, economic, and natural (incl. terrain, climate) drivers on carbon storage are further examined. The findings revealed that: (1) The most carbon storage growth projected from 2030 to 2060 reaches 1.53 %, but of which localized SSP5–8.5 narrative the urbanization encroached upon the undeveloped mountainous, severely impairing carbon sequestration by 81.5Tg. (2) In addition to landscape types, carbon storage exhibits complex spatial responses to economic development, population size, and terrain with an inverted U-shaped relationship. The proposed methodology offers more accurate carbon storage estimates and assists policy-makers in similar terrains to effectively manage the spatial heterogeneity of carbon storage. This study facilitates the implementation of tailored ecological conservation through urban zoning, thus contributing to enhanced subregional climate change mitigation efforts globally.

Unlocking subsidiary performance: exploring the impact of subsidiary TMT composition, PCN tenure and subsidiary age

PurposeThe purpose of this paper is to study the relationship between subsidiary manager’s demographic characteristics and performance, while incorporating the subsidiary context. We draw upon upper echelon theories and International Business theories to understand this relationship.Design/methodology/approachUsing a dataset based on listed Multinational subsidiaries in India we use linear regression to establish the relationship between subsidiary external performance (host market performance), subsidiary internal performance and subsidiary manager’s demographic characteristics.FindingsWith our data set we find a positive relationship between percentage of host country nationals (HCN) in the Top Management Team (TMT) and subsidiary host market performance and that subsidiary age moderates this relationship. We also find an inverted U-shaped relationship between parent country nationals (PCN) tenure and subsidiary performance.Research limitations/implicationsOne of the limitations is that our study views the strategy process through the Upper Echelons (UE) theory lens, as a clearly specified planning process that associates strategy with intentionality. The opportunity that emanates at lower levels can turn an intended strategy into something different than what was started.Practical implicationsThe findings in this paper can be the basis for decision making on the constitution of leadership teams.Originality/valueThere is a dearth of empirical evidence and studies on TMTs in the subsidiary, particularly from the non-North American context. Using a unique data set of listed multinational subsidiaries in India, the paper explores the impact of TMT demographics such as tenure of the TMT and age of the subsidiary operations on the performance of the subsidiary.

U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

BackgroundEvidence regarding the relationship between fasting blood glucose (FBG) and suicide attempts (SA) in patients with major depressive disorder (MDD) was limited. Therefore, the objective of this research was to investigate whether FBG was independently related to SA in Chinese patients with first-episode drug-naïve (FEDN) MDD after adjusting for other covariates.MethodsThe present study was a cross-sectional study. A total of 1718 participants (average age: 34.9 ± 12.4 years, 65.8% females) with FEDN MDD were involved in a hospital in China from September 2016 to December 2018. Multiple logistic regression analysis and smooth curve fitting were used to estimate the association between FBG and the risk of SA. The threshold effect was examined by the two-piecewise linear regression model. Interaction and stratified analyses were conducted according to sex, education, marital status, comorbid anxiety, and psychotic symptoms.ResultsThe prevalence of SA in patients with FEDN MDD was 20.1%. The result of fully adjusted binary logistic regression showed FBG was positively associated with the risk of SA (odds ratio (OR) = 1.62, 95% CI: 1.13–2.32). Smoothing plots also revealed a nonlinear relationship between FBG and SA, with the inflection point of FBG being 5.34 mmol/l. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 0.53 (0.32–0.88, P = 0.014) and 1.48 (1.04–2.10, P = 0.030), respectively.ConclusionsA U-shaped relationship between FBG and SA in FEDN MDD patients was found, with the lowest risk of SA at a FBG of 5.34 mmol/l, indicating that both the lower and higher FBG levels may lead to an increased risk of SA.

The effects of hoof health and hoof trimming on farm profitability

Animal diseases pose a significant threat to the global livestock industry, with severe economic consequences. To minimize this impact, farmers employ various preventative measures, with hoof trimming being the most common method for addressing hoof disorders. This study analysed the economic effects of hoof trimming on dairy farms, using a panel dataset containing three years of hoof health data across Finland. This was an observational study that also addressed the issue with unavoidable confounders. To reduce bias, inverse propensity score weighting (IPW) was used, which assigned weights based on the probability density function of treatment frequency. By reweighting the data, this study improved the validity of the causal inference in the presence of confounding unobserved variables. The results of the study indicated that both infectious and non-infectious hoof disorders were notable on dairy farms in Finland. Furthermore, frequency of hoof trimming was influenced by several factors, including hoof health, farm characteristics, and management decisions. The analysis suggested a U-shaped relationship between hoof trimming and farms' profitability. Although the profitability ratio initially decreased, it increased after reaching a hoof trimming level of 97 %. The study highlighted how important systematic and regular hoof trimming is to maintain profitability.

The relationship between dietary total flavonoids and thyroid function in U.S.adults, NHANES 2007-2010.

Although small studies have shown that flavonoids can affect thyroid disease, few epidemiological studies have explored the relationship between dietary total flavonoids (TFs) intake and serum thyroid function. The aim of this research was to evaluate the relationship between TFs and serum thyroid function. Our study included 4,949 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Multivariable linear regression, subgroup analyses, and interaction terms were used to explore the relationships between TFs and thyroid function. And we also used restricted cubic splines (RCS) to investigate possible nonlinear relationships. After adjusting for covariates, we found that log10-transformated dietary total flavonoids intake (LgTFs) was negatively associated with total thyroxine (TT4) (β = -0.153, 95% CI = -0.222 to -0.084, P<0.001). Subgroup analyses revealed a stronger and statistically supported association in subjects with high annual family income (β = -0.367, P<0.001, P for interaction = 0.026) and subjects with high poverty to income ratio (PIR) (β = -0.622, P<0.001, P for interaction = 0.042). And we found a U-shaped curve association between LgTFs and free triiodothyronine (FT3) (inflection point for LgTFs: 2.063). The results of our study demonstrated that a higher intake of total flavonoids in the diet was negatively associated with a lower TT4. Furthermore, the associations were more pronounced in high annual family income and high PIR adults. And we found a U-shaped relationship between LgTFs and FT3. These findings provided guidance for future thyroid dysfunction diet guidelines.

Association between protein intake, serum albumin and blood eosinophil in US asthmatic adults

BackgroundPresently, numerous studies have indicated that protein consumption and levels of blood albumin serve as important biomarkers for a range of respiratory illnesses. However, there have been few investigations into the correlation between protein consumption, serum albumin, and asthma.MethodsOur analysis incorporated 2509 asthmatics from the 2011–2018 NHANES dataset. The investigation employed three linear regression models and XGBoost model to investigate the potential link between protein intake, serum albumin levels, and blood eosinophil counts (BEOC) in patients with asthma. The trend test, generalized additive model (GAM), and threshold effect model were utilized to validate this correlation. As well, we undertook stratified analyses to look at the correlation of serum albumin with BEOC among distinct populations.ResultsIn the univariable regression model, which did not account for any covariates, we observed a positive correlation between protein intake and BEOC. However, univariable and multivariable regression analyses all suggested a negative connection of serum albumin with BEOC in asthma populations. In Model C, which took into account all possible factors, BEOC dropped by 2.82 cells/uL for every unit increase in serum albumin (g/L). Additionally, the GAM and threshold effect model validated that serum albumin and BEOC showed an inverted U-shaped correlation.ConclusionOur investigation discovered there was no independent link between asthmatics’ protein intake and BEOC. However, we observed an inverted U-shaped relationship between serum albumin levels and BEOC, suggesting a possible relationship between the overall nutritional status of asthmatics and immune system changes. Our findings provide new directions for future research in the field of asthma management and therapy.

Environmental regulation, industrial structure and energy efficiency: Evidence from 30 provinces in China.

The government's environmental protection policy can significantly contribute to alleviating resource shortages and curbing environmental pollution, but the impact of various policy instruments implemented by the government on energy efficiency is unclear. Based on the panel data of 30 provinces in China from 2005 to 2021, this paper analyses the impact of environmental regulation and the industrial structure on energy efficiency from the perspective of resource taxes. The U-shaped relationship between environmental regulation and energy efficiency and between the optimization of industrial structure can significantly improve energy efficiency, and the optimization of industrial structure is conducive to weakening the initial inhibitory effect of environmental regulation. In addition, the analysis of regional heterogeneity showed that the impact of environmental regulation was stronger in the central and western regions, while the impact of industrial structure was stronger in the eastern and western regions. The conclusions of this study can help to expand the understanding of the relationship between environmental regulation and industrial structure on energy efficiency, provide policy enlightenment for the realization of green development and high-quality development, and provide Chinese examples and experiences for developing countries to improve energy efficiency.

Knowledge Element Relationship and Value Co-Creation in the Innovation Ecosystem

In the era of Innovation 3.0, more and more enterprises are working together to build an innovation ecosystem to achieve value creation. The various participants in the innovation ecosystem promote resource aggregation and integration through cross boundary collaboration, jointly creating the value of the ecosystem. Value co-creation has become the core goal pursued by the participants in the innovation ecosystem. As an innovative participant in the innovation ecosystem, it is particularly necessary for enterprises to explore the formation mechanism of value co-creation from the perspective of enterprise knowledge characteristics. This article analyzes the value co-creation mechanism of innovation ecosystems from the perspective of including internal knowledge bases and external relationships. Based on the dimension of knowledge element relationships, a theoretical model is constructed to investigate the impact of enterprise knowledge element relationships on value co-creation in innovation ecosystems and explore the mediating role of knowledge synergy and the moderating role of innovation ecosystem normativity. The relationships are modeled based on survey data collected from 427 Chinese companies, and multiple regression analysis and bootstrap methods are used to empirically test the hypotheses. The research results show that different dimensions of knowledge element relationships have different impacts on value co-creation. Knowledge element substitution negatively affects value co-creation, while knowledge combination diversity positively affects value co-creation. However, there is an inverted U-shaped relationship between knowledge element complementarity and value co-creation. Knowledge synergy partially mediates the relationship between knowledge element relationships and value co-creation, and innovation ecosystem normativity has a two-stage moderating effect on the path from knowledge element relationships to knowledge synergy to value co-creation. This article enriches the research content of knowledge management in innovation ecosystems, guides enterprises in the innovation ecosystem to reasonably construct their own knowledge systems, and promotes the formation of innovation ecosystem norms, thus promoting the development of value co-creation activities.