Types Of Wound Dressings Research Articles

Design And Characterization Of Regenerative Potential In Full Thickness Burn Wound Model

Hydrogel is a three-dimensional network of interconnecting polymers that is crosslinked and consists of hydrophilic polymers that can absorb and endure water. Because it mimics the extracellular matrix (ECM), the hydrogel has found widespread use in pharmacological and biological applications. Many types of wound dressings are based on hydrogels due to its many advantages. These dressings include Coseal, Tegaderm, Algisite, and Evicel. Notwithstanding their exceptional ability to cure wounds, they have many drawbacks, including expensive expenses, unfavourable storage conditions, and inadequate mechanical protection for the wound. As we have come to realise the need for dressings with greater performance qualities (e.g., antimicrobial, biodegradable, responsive, and injectable), the field of wound dressings has attracted an increasing amount of interest. The purpose of this work is to evaluate the hydrogel loaded with 7, 8-Dihydroxy flavone's healing capabilities in a full-thickness burn wound model.

An Injectable Thermosensitive Hydrogel with Antibacterial and Antioxidation Properties for Accelerating Wound Healing.

As a new type of wound dressing, hydrogels have attracted more and more attention. However, traditional hydrogel wound dressings lack inherent antibacterial properties and are difficult to match irregular wounds, which leads to an easy wound bacterial infection. To solve the problems associated with traditional hydrogels, in this research, a thermosensitive hydrogel (PFLD) for wound dressings was developed based on Poloxamer 407 (PF127), lysine (Lys), and 3,4-dihydroxyphenylacetic acid (DOPAC). Rheological tests indicated that the PFLD hydrogel possesses injectability, adaptability to deformation, and sufficient mechanical strength for wound dressing applications. In addition, it could in situ gel at 33 °C, which indicated that the hydrogel could undergo sol-to-gel transition under body temperature. Upon using it in wound treatment, it could adapt to irregular wounds to achieve full coverage of the wound and promote the rapid hemostasis of wound bleeding. Due to the presence of DOPAC in the hydrogel, it exhibited excellent antibacterial and antioxidant properties on the wounds. The skin defect model showed that the wound shrinkage was the fastest after PFLD hydrogel treatment. On day 14, the wound shrinkage rates were 81.68 and 99.77% for the control and PFLD hydrogel groups, respectively. Therefore, the PFLD hydrogel has a broad application prospect as a dressing for the treatment of irregular wounds.

Carboxymethyl cellulose/sodium alginate hydrogel with anti-inflammatory capabilities for accelerated wound healing; In vitro and in vivo study

Recently, managing the chronic skin wounds has become increasingly challenging for healthcare professionals due to the intricate orchestration of cellular and molecular processes involved that lead to the uncontrollable inflammatory reactions which hinder the healing process. Therefore, different types of wound dressings with immunomodulatory properties have been developed in recent years to effectively regulate the immune responses, enhance angiogenesis, promote re-epithelialization, and accelerate the wound healing process. This study aims to develop a new type of immunomodulatory wound dressing utilizing carboxymethyl cellulose (CMC)/sodium alginate (Alg)-simvastatin (SIM) to simultaneously enhance the inflammatory responses and the wound healing ratio. The CMC/Alg-SIM hydrogels exhibited appropriate swelling ratio, water vapor transmission rate, and desirable degradation rate, depending on the SIM content. The fabricated dressing showed sustained release of SIM (during 5 days) that improved the proliferation of skin cells. According to the in vitro findings, the CMC/Alg-SIM hydrogel exhibited controlled pro-inflammatory responses (decreased 2.5- and 1.6-times IL-6 and TNF-α, respectively) and improved secretion of anti-inflammatory cytokines (increased 1.5- and 1.3-times IL-10 and TGF-β, respectively) in comparison with CMC/Alg. Furthermore, the CMC/Alg-SIM hydrogel facilitated rapid wound healing in the rat model with a full-thickness skin defect. After 14 days post-surgery, the wound healing ratio in the CMC/Alg hydrogel group (∼93%) was significantly greater than the control group (∼58%). Therefore, the engineered CMC/Alg-SIM hydrogel with desired immunomodulatory properties possesses the potential to enhance and accelerate skin regeneration for the management of chronic wound healing.

Efficacy of Honey-Based Wound Dressing Versus Hydrogel-Based Wound Dressing in Wound Healing Process: A Literature Review

Introduction: Wound dressing is a fundamental aspect of modern healthcare, encompassing a diverse range of materials and techniques aimed at optimizing the healing process while safeguarding against infection and further injury. By understanding the specific benefits of different types of wound dressings, healthcare professionals can optimize the healing process and improve patient outcomes Methods: This literature review was compiled using information from various open access online databases. Data were collected and analyzed. Results and Discussions: Honey dressing demonstrates superior efficacy compared to hydrogel dressing in wound management. Its multifaceted properties, such as potent antimicrobial activity, tissue regeneration promotion, and anti-inflammatory effects, render it a superior option for wound healing throughout all stages. Additionally, honey is more cost-effective than hydrogel and more easily accessible. Conclusion: The efficacy of honey dressing surpasses that of hydrogel dressing in wound management. Honey's multifaceted properties, including its potent antimicrobial activity, ability to promote tissue regeneration, and anti-inflammatory effects, make it a superior choice for wound healing across all phases.

Advancements and applications of upconversion nanoparticles in wound dressings.

Wound healing is a complex process that requires effective management to prevent infections and promote efficient tissue regeneration. In recent years, upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing applications due to their unique optical properties and potential therapeutic functionalities. These nanoparticles possess enhanced antibacterial properties when functionalized with antibacterial agents, helping to prevent infections, a common complication in wound healing. They can serve as carriers for controlled drug delivery, enabling targeted release of therapeutic agents to the wound site, allowing for tailored treatment and optimal healing conditions. These nanoparticles possess the ability to convert near-infrared (NIR) light into the visible and/or ultraviolet (UV) regions, making them suitable for therapeutic (photothermal therapy and photodynamic therapy) and diagnostic applications. In the context of wound healing, these nanoparticles can be combined with other materials such as hydrogels, fibers, metal-organic frameworks (MOFs), graphene oxide, etc., to enhance the healing process and prevent the growth of microbial infections. Notably, UCNPs can act as sensors for real-time monitoring of the wound healing progress, providing valuable feedback to healthcare professionals. Despite their potential, the use of UCNPs in wound dressing applications faces several challenges. Ensuring the stability and biocompatibility of UCNPs under physiological conditions is crucial for their effective integration into dressings. Comprehensive safety and efficacy evaluations are necessary to understand potential risks and optimize UCNP-based dressings. Scalability and cost-effectiveness of UCNP synthesis and manufacturing processes are important considerations for practical applications. In addition, efficient incorporation of UCNPs into dressings, achieving uniform distribution, poses an important challenge that needs to be addressed. Future research should prioritize addressing concerns regarding stability and biocompatibility, efficient integration into dressings, rigorous safety evaluation, scalability, and cost-effectiveness. The purpose of this review is to critically evaluate the advantages, challenges, and key properties of UCNPs in wound dressing applications to provide insights into their potential as innovative solutions for enhancing wound healing outcomes. We have provided a detailed description of various types of smart wound dressings, focusing on the synthesis and biomedical applications of UCNPs, specifically their utilization in different types of wound dressings.

THE ROLE OF WOUND COVERINGS IN THE MAXILLARY TREATMENT OF BURN LESIONS (LITERATURE REVIEW)

Currently, in medicine the number of patients with burn injuries. This necessitates further improvement of local treatment methods for such patients. Although several types of wound dressings have been developed, no gold standard has yet been developed. Therefore, the development of easy-to-use, bactericidal effective and inexpensive wound coverings is relevant, taking into account the requirements for coatings.

Investigation of the formation mechanism of AgNPs-GO in AgNPs-GO liquid band-aids using molecular dynamics simulations, and the effect of GO oxidation on solubility and silver loading

Background and purposeLiquid bandages belong to a new type of wound dressing. Compared to traditional band-aids, liquid bandages are generally suitable for superficial wounds. They are convenient to use, quickly seal wounds, can be applied to special areas, provide a transparent and aesthetically pleasing film after application, and have other functions such as waterproofing. However, there has been limited research on the application of carbon-based materials in antibacterial dressings. MethodsIn this study, the formation mechanism of silver nanoparticle-graphene oxide composites was investigated using computer molecular simulation methods. The influence of graphene oxide oxidation degree on solubility and silver loading was studied. ResultsThrough radial distribution function analysis, it was shown that the solubility of graphene oxide gradually increased and stabilized at 32.5%. Due to steric hindrance and solvent effects, the silver loading continuously decreased and stabilized at 22.5%. These results provide simulated references for further prescription optimization and production process optimization. ConclusionThe simulation results indicate that silver nanoparticles gradually approach, adsorb, and aggregate on the surface of graphene oxide in the solution system. With an increase in the oxidation degree, the solubility of graphene oxide continuously increases, while the silver loading continuously decreases and stabilizes.

Electrospinning of peanut protein isolate/poly-L-lactic acid nanofibers containing tetracycline hydrochloride for wound healing

In the present study, we explored the feasibility of using electrospinning technology to prepare tetracycline-hydrochloride (TCH)-containing peanut protein isolate/poly-L-lactic acid (TCH/PPI/PLLA) nanofiber membranes as a new type of wound dressing. PPI was prepared using the alkali-dissolved acid precipitation method, and PPI/PLLA nanofibers containing TCH at mass loadings of 5%, 10%, and 15% were prepared by electrospinning. The resultant nanofibers were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and comprehensive thermal analysis. Furthermore, the wettability, mechanical properties, and drug release efficacy of the TCH/PPI/PLLA nanofibers were evaluated, and their effect on Staphylococcus aureus and mouse skin fibroblasts were investigated. A mouse-skin wound model was established to assess the healing effect of TCH/PPI/PLLA nanofibers. The results revealed that TCH exists in the nanofibers in an amorphous state, and that the addition of TCH has no observable effect on the morphology of the nanofiber membrane. As the TCH content increases, the fiber diameter decreases, while the mechanical strength and wettability of the membranes increase. TCH/PPI/PLLA composite nanofibers provide a significant initial release of TCH, and the release mechanism of TCH appears to be Fick's diffusion. The hemolysis rates of the electrospun PLLA nanofibers, PPI/PLLA composite nanofibers, and drug-loaded PPI/PLLA nanofibers are all below 5%. TCH retains its anticoagulant effect when composited with the PPI/PLLA composite nanofibers and exhibits low toxicity to cells. The PPI/PLLA nanofiber membrane loaded with TCH has an inhibitory effect on S. aureus and E. coli，and promotes skin-wound healing in mice. Therefore, TCH/PPI/PLLA nanofiber membranes prepared by electrospinning technology show promise as a next-generation wound dressing material.

Types of Wound Dressings and Materials used in Mild to Moderately Exuding Wounds: A Review

In this review wehave focused upon the various wound types, wound dressing stages, and wound dressing classification and characteristics. The main objective of this review is to explain the purpose of wound dressings and different types of wound dressings used. Further we have emphasized upon various biomaterials employed in dressings and their need in specific wound dressings. Biomaterials are used in the dressings to improve the healing rate of the injury, maintain moisture at the area of wound, heamostasis and reduce inflammation. So, to achieve this purpose, various approaches of wound dressings and the role of various biomaterials are also discussed. The properties, methods of preparation, advantages, and disadvantages along with future scope are discussed.

Characteristics and Safety Profiles of a Hydrocolloid Polyester Dressing Incorporated with Herbal Extract: In Vitro, in Vivo and Randomized Clinical Studies.

The polyester dressing containing herbal extract had been used for several years. However, some properties had not been investigated. This study examined three parts including in vitro studies, skin irritation in an animal model, and the pilot clinical study in traumatic wounds. In in vitro studies, six different wound dressings consisted of hydrocolloid polyester containing herbal extract (SI-HERB®), hydrofiber (Aquacel®), hydrocolloid polyester (Urgotul®), soft paraffin gauze (Bactigras®), foam (Mepilex®), and biocellulose (Suprasorb® X + PHMB) dressings were comparatively evaluated in physical properties including the fluid absorption, desorption, and fluid drainage ability. The skin irritation test was examined in a rabbit model using SI-HERB® as a tested group. In a clinical study, traumatic patients with leg wounds were randomly assigned to six wound dressings. The primary outcome was the pain level and the secondary outcomes were non-adherence and peri-wound reaction evaluating score. From the study, Bactigras® had the largest pore size but the total area of pore size per field of it was similar to SI-HERB®. There were no significant differences between SI-HERB®, Urgotul®, and Bactigras® in the percentage of absorption and desorption. No dermatologic effect was found in the animal study. In the irritation test on leg wounds, pain level, and peri-wound reaction in hydrocolloid polyester dressing group were significantly lower compared with Aquacel® and Bactigras®. The polyester dressing had the pain level after removal lower than before application while the Mepilex® and Suprasorb® presented that insignificantly increase the pain level. Erythema could be observed in Bactigras®, Aquacel®, and Suprasorb® but the edema scores were not different. A hydrocolloid polyester dressing containing herbal extract had good drainage ability. No skin irritation was reported. Pain scores, removal ability, and peri-wound reaction were also significantly lower with other types of wound dressings. These results suggested that this dressing be an alternative in wound treatment.

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing.

The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

Wound dressing products: A translational investigation from the bench to the market

Chronic skin wounds affect more than 40 million patients globally and represent a severe growing burden for the healthcare systems, with annual costs expected to exceed $15 billions by 2022. To satisfy the huge demand for effective wound care products, different types of wound dressings have been introduced on the market during the last decades. Based on “the moist wound healing theory” postulated by Prof Winter in 1962, bandages were initially designed to recreate the optimal wound environment to favor the healing process. Then, thanks to the advancements achieved in biomaterial design and processing, biotechnology, imaging and electronic fields, great effort has been devoted to the development of formulations able to actively participate to tissue healing. Indeed, both the literature and the market report the design of medicated wound dressings, i.e., wound care products releasing anti-microbial agents, anti-inflammatory drugs, or bioactive molecules. In this scenario, this review aims at critically describing the currently available wound care products, highlighting their proved effectiveness in wound management. Moreover, an overview of the main strategies exploited to design personalized wound dressings has been reported. Lastly, concerns on regulatory affairs and practical issues limiting the clinical translation of advanced research platforms have also been discussed.

Negative pressure wound therapy for surgical wounds healing by primary closure.

Negative pressure wound therapy for surgical wounds healing by primary closure.

PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing

Chronic wounds represent a major challenge to the present healthcare system. In recent decades, many topical therapies have been investigated for the treatment of chronic wounds, including different types of wound dressings, antimicrobial agents, and cell therapy. Platelet-derived growth factor (PDGF) plays an important role in wound healing and has been approved for treatment of wounds related to diabetes mellitus. However, the high cost and short retention time of PDGF protein have limited its wide application. To overcome this challenge, we designed a PDGF-mimicking peptide by connecting PDGF epitope VRKIEIVRKK and self-assembling motif derived from β-amyloid peptide. The resultant peptide can self-assemble into a fibril-rich network and leads to supramolecular hydrogelation with good stability. The hydrophilic epitope can be exposed on the surface of nanofibrils, which might contribute to the binding and activation of PDGF receptors. The forming hydrogel is able to induce the growth and migration of vascular endothelial cells and promote the formation of vascular branches. In the full-thickness skin wounds of healthy mice, after the application of the hydrogel, the density of neovascularization marked by CD31 was greater than that in the control group on Day 3. Larger collagen deposition and a thicker epidermis were observed on Day 12. These results demonstrate that the hydrogel can stimulate collagen deposition and angiogenesis, enhance skin regeneration, and show an excellent therapeutic effect. Taken together, this work not only provides new insight into the design of bioactive peptides but also offers a promising biomaterial for wound healing.

Adsorbent Dressings from Sodium Carboxymethyl Cellulose With Silver Ions in Primary Knee Arthroplasty: A Randomized Trial

Background. The ideal wound dressing should have complex positive affect on a postoperative wound healing: absorb excessive wound exudate, allow adequate gas exchange, prevent secondary infectious complications, create optimal humidity, be durable and not to restrict patients mobility, which is crucial for early mobilization after total knee arthroplasty. We carried out this research to asses the effectiveness and safety of contemporary adhesive wound dressings and if they do have the abovementioned qualities.
 Aim to assess the effect of using absorbing wound dressing made from sodium carboxymethyl cellulose with silver ions on the quality of rehabilitation and the rate of superficial infection occurrence in patients who underwent total knee joint arthroplasty.
 Methods. This prospective randomized (simple randomization) paralleled open study included 200 patients with terminal stage knee arthritis, who required total knee joint arthroplasty. Patients were divided into three groups, in two of the groups the innovate wound dressing made from sodium carboxymethyl cellulose with silver ions was used, in the third group traditional wound dressing was used.
 Results. In the course of this study, it was confirmed that there was no statistically significant difference in pain syndrome intensity in the early postoperative period or Knee Society Score (KSS) at 3 months postoperatively in regard of type of wound dressing and time of its application. Subjectively the most comfortable wound cover method for the patients was the usage of adhesive dressings with silver impregnation from the first day postoperatively. As complications we observed epidermal blistering under the dressing, superficial wound necrosis, superficial wound infection and formation of prominent and rough postoperative scars. The highest rate of blistering was observed in patients with traditional patch wound dressing.
 Conclusions. The usage of absorbing wound dressing made from sodium carboxymethyl cellulose with silver ions in our current study did not affect the rate of infectious complications and did not have any negative effects on rehabilitation. The usage of innovate dressings reduced the rate of epidermal blistering associated with dressings.

A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing

Although various dressings currently used have the effect of promoting wound healing, they still cannot meet the requirements of clinically efficient treatment. Recently, parathyroid hormone (PTH) and its pathway have been shown as the new target for wound repair. However, using PTH in clinical wound treatment can be a question. This study is to develop a novel PTHrP-2 loaded cellulose acetate nanofiber mat (CAP) via electrospinning to benefit wound repair. By observing the effects of prepared CAP on cell proliferation, migration, tube formation, and wound healing in the rat models, we have evaluated the safety and effectiveness of CAP. With the extract of CAP, the viability of human umbilical vein endothelial cells and fibroblasts was enhanced. It also could significantly increase the movement rate of human umbilical vein endothelial cells and promote tube formation. The wound closure speed of CAP treatment was significantly faster than the cellulose acetate group. In conclusion, CAP has a promoting effect in angiogenesis, collagen formation and re-epithelialization, thereby it can accelerate wound healing. CAP is a promising translational nanocomposite material, which might be transferred into a new type of wound dressing.

Preparation and application of sodium alginate hydrogel film loaded with nano-silver/graphene composite

Sodium alginate (SA) is a natural polymer material that has been widely studied and used in the biomedical field. Nano-silver (Ag) has been proven to present good antibacterial properties, but its application is limited due to its easy agglomeration. In this paper, a series of Ag-graphene composites (Ag-GO) were prepared and characterized by loading Ag nanoparticles on the surface of graphene oxide (GO) sheets. Ag-GO was then added into SA, and a double-layered SA hydrogel film (Ag-GO/SA) carrying Ag-GO was prepared by sol-gel process. FTIR, XRD and SEM characterizations were used to determine the chemical structure and micromorphology of Ag-GO/SA. In addition, swelling ability, mechanical and antibacterial properties, as well as in-vitro cytotoxicity and in-vivo wound healing ability of Ag-GO/SA samples were also evaluated. The results show that the prepared Ag-GO/SA has good swelling property, sufficient mechanical strength, excellent wound healing and antibacterial properties. Specially, the optimum hydrogel of Ag-GO/SA can promote wound healing in SD rats, with a wound healing rate of up to 98%, presenting great application potential as a new type of wound dressing.

Enhancing wound healing dressing development through interdisciplinary collaboration.

The process of wound healing includes four phases: Hemostasis, inflammation, proliferation, and remodeling. Many wound dressings and technologies have been developed to enhance the body's ability to close wounds and restore the function of damaged tissues. Several advancements in wound healing technology have resulted from innovative experiments by individual scientists or physicians working independently. The interplay between the medical and scientific research fields is vital to translating new discoveries in the lab to treatments at the bedside. Tracing the history of wound dressing development reveals that there is an opportunity for deeper collaboration between multiple disciplines to accelerate the advancement of novel wound healing technologies. In this review, we explore the different types of wound dressings and biomaterials used to treat wounds, and we investigate the role of multidisciplinary collaboration in the development of various wound management technologies to illustrate the benefit of direct collaboration between physicians and scientists.

Bovine Based Collagen Dressings in Wound Care Management

Collagen plays a significant role in treating acute and chronic wounds such as cuts, burns, ulcers associated with other illness via enhancing the debridement of infected tissues, angiogenesis and promoting natural growth. There are several types of collagen, which can be obtained from various animal sources such as chicken, bovine, porcine, fish etc. Among that bovine based collagen contributed many shares towards biomedical application. Nowadays using bovine based collagen biomaterials for wound care is in trend to minimize the negative impacts such as infection, pain and other side effects. However, its applicable and effectiveness are not fully revealed. At the same time, clinicians and researchers are exploring and implementing advanced techniques and treatment procedures to reduce the wound healing burden effectively. In this review, we aimed to focus on the fundamental information about types of wound dressings, collagen dressings and the clinical utility of bovine based collagen dressings in providing essential knowledge in advanced wound care management.

Aloe vera: A Medicinal Plant Used in Skin Wound Healing.

Skin injury is a major problem threatening human physical and mental health, and how to promote wound healing has been the focus. Developing new wound dressings is an important strategy in skin regeneration. Aloe vera is a medicinal plant with a long history, complex constituents, and various pharmacological activities. Many studies have shown that A. vera plays an important role in promoting wound healing. Adding A. vera to wound dressing has become an ideal way. This review will describe the process of skin injury and wound healing and analyze the role of A. vera in wound healing. In addition, the types of wound dressing and the applications of A. vera in wound dressing will be discussed.