The study of the cooling efficiency of vegetation in urban residential areas at a micro-scale is important for improving the thermal environment of those areas. The quantitative analysis of the effect of the layout of different building patterns on the cooling efficiency of green space is particularly crucial. This study takes a typical residential area with a row-column arrangement in Jiangning District, Nanjing City, Jiangsu Province, China, as the research object. Using the ENVI-MET model used for numerical simulation, 15 simulation scenarios were designed based on building orientation, height, and density. The research proposes the methodology of the regional cooling efficiency (RCE) of urban residential vegetation, reveals the daily variation characteristics of the RCE of vegetation in a residential area, and analyzes the factors influencing of regional cooling efficiency. The results showed that the daily variation in RCE for vegetation in the residential area exhibited a single-peak trend. The minimum and maximum RCE values appeared at 6:00 and 14:00, respectively. The average air temperature and building density in the residential area had a significant positive correlation with RCE, while average relative humidity had a negative correlation. Average wind speed, average building height, and average sky view factor showed nonlinear correlations with RCE, and the importance ranking of each factor's effect on RCE was air temperature > relative humidity > building density > wind speed > building height > sky view factor. This study will provide theoretical support for improving the thermal environment in urban residential areas during the urban planning process.