Types Of Radiopharmaceuticals Research Articles

The Application of Radiolabeled Targeted Molecular Probes for the Diagnosis and Treatment of Prostate Cancer.

Radiopharmaceuticals targeting prostate-specific membrane antigens (PSMA) are essential for the diagnosis, evaluation, and treatment of prostate cancer (PCa), particularly metastatic castration-resistant PCa, for which conventional treatment is ineffective. These molecular probes include [68Ga]PSMA, [18F]PSMA, [Al18F]PSMA, [99mTc]PSMA, and [89Zr]PSMA, which are widely used for diagnosis, and [177Lu]PSMA and [225Ac]PSMA, which are used for treatment. There are also new types of radiopharmaceuticals. Due to the differentiation and heterogeneity of tumor cells, a subtype of PCa with an extremely poor prognosis, referred to as neuroendocrine prostate cancer (NEPC), has emerged, and its diagnosis and treatment present great challenges. To improve the detection rate of NEPC and prolong patient survival, many researchers have investigated the use of relevant radiopharmaceuticals as targeted molecular probes for the detection and treatment of NEPC lesions, including DOTA-TOC and DOTA-TATE for somatostatin receptors, 4A06 for CUB domain-containing protein 1, and FDG. This review focused on the specific molecular targets and various radionuclides that have been developed for PCa in recent years, including those mentioned above and several others, and aimed to provide valuable up-to-date information and research ideas for future studies.

The role of positron emission tomography in the diagnosis and treatment of oncological diseases of the hepatobiliary system

The article highlights the role of PET and SIRT in the diagnosis and treatment of cholangiocarcinoma and HCR. In HCR, PET can be useful in detecting distant metastases, assessing overall and recurrence-free survival. In the case of cholangiocarcinoma, PET is more diagnostically informative than CT when detecting distant metastases and plays an important role in predicting recurrence after surgical resection. Data on the use of various types of radiopharmaceuticals and their combinations are provided. A comparison of their sensitivity and specificity is presented, which showed the best results when using the combination of FDG + choline. The effectiveness of PET in the selection of patients before transplantation, the ability to assess the distribution of activity and to quantify the absorbed dose in SIRT, which in turn allows to predict the therapeutic response and outcome, has been demonstrated. Different types of microspheres for SIRT are considered, in particular, 90Y-resin, 90Y-glass, and 166Ho-poly-L-lactic acid (PLLA). Among them, the most interesting are 166Ho microspheres, which have the advantage of being able to perform diagnostics and treatment with the same radiological label, i.e., to be used in a theranostic approach, theoretically reducing discrepancies between the planning and treatment procedure. SIRT can be used both alone and in combination with other types of treatment at different stages of tumor disease.

Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery

The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.

Multivariate optimization and validation of a procedure to direct determine acetonitrile and ethanol in radiopharmaceuticals by GC-FID

A fast and simplified analytical procedure was developed and validated for the direct determination of organic solvents (acetonitrile and ethanol) in radiopharmaceuticals samples ([18F]FMISO, [18F]FES and [18F]FLT) by gas chromatography coupled with flame ionization detection (GC-FID). Optimization studies were performed with the aid of two-level full factorial design. The optimum conditions were located using Derringer's desirability function. Procedure validation assured the compliance of the assay to Brazilian regulatory agencies standards (ANVISA and INMETRO). Values for LOD and LOQ were commensurate with the level at which the impurities must be controlled. Good linearity was achieved (R ≥ 0.990) for acetonitrile and ethanol concentrations ranging from 0.003 to 0.09% (w/v) and 2.1 to 11.0% (v/v), respectively. Accuracy and precision assessments were performed using samples fortified with standards (spiked samples). The developed procedure proved to be selective, sensitive, accurate (95.9–117.8% of nominal values) and precise (RSD ≤ 9.7%). The validated procedure was successfully used to assess organic solvents levels in a Brazilian radiopharmaceuticals samples manufactured by Radiopharmaceutical Research and Production Unit of Nuclear Technology Development Center (CDTN), in Belo Horizonte (Brazil). The analytes could be well resolved in 1.5 min and accurately determined in three different types of radiopharmaceuticals. This procedure is applicable to samples even with high ethanol content up to 11% (v/v). Other advantages include no sample preparation, short chromatographic separation time and minimum manual operation. As results, the proposed procedure can be useful in the routine analysis for the determination of acetonitrile and ethanol in radiopharmaceutical samples.

Development of the automatic adjustment system for the appropriate radiopharmaceutical dose

Introduction In nuclear medicine examination, it is required to adjust appropriately radiopharmaceutical dose for patient by the patient’s age and physique. Purpose In this study, the system for adjusting an appropriate radiopharmaceutical dose automatically was developed. Materials and methods This system of the developed can calculate appropriate radiopharmaceutical dose based on some guideline of scientific society, and adjust the quantity of solution in syringe by inputting some patient information and the substance of examination. The text data of the information about adjustment are saved on PC after adjusted the quantity of solution. Further the label for pasting on syringe is outputted with a printer. Also the difference between the quantity of solution in syringe filled at dispenser and the calculated volume has been investigated by using various type of radiopharmaceuticals. Results This system consisted of a barcode reader, a PC, a dispenser and a label printer. The size of dispenser is 130 mm × 380 mm × 285 mm, and the weight is 4730 g. The difference between the quantity of solution in syringe filled at dispenser and the calculated volume with PC was 2% or less, and it was shown that it is satisfactory in the practical needs. Conclusion This system adjusts automatically an appropriate radiopharmaceutical dose just inputting some patient information and the substance of examination. This system is efficient of a quality assurance of nuclear medicine examinations. Disclosure We have no disclosure and financial support.

Producción de radiofármacos para tomografía por emisión de positrones (PET) y su aplicación en el diagnóstico de diversas enfermedades

The radioactivity is more known for adverse effects by the explosion of atomic bombs in World War II, but also has features beneficial to health care since it serves for the early diagnosis of diseases to your treatment. This paper presents, from a perspective of chemical education, the fundamental concepts of the Emission of Positron Tomography (PET). Also explains the process of production of radiopharmaceuticals for PET, in particular 18F. Also, different types of radiopharmaceuticals used for diagnosis of oncological, neurological and cardiac diseases are discussed. The use and clinical applications of this method of Imaging is already a reality in Mexico since 2005. It is expected students and teachers of the area chemical biological sciences achieve a better understanding and an overview of the scope and applications that this technique can have.

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials.

Coated magnetite nanoparticles were linked to 68Ga complexes used in the positron emission tomography (PET) for a new technical approach to detect cancer tissue with radiopharmaceuticals. By substitution of the Ga isotope with an alpha emitter the same compound could be used for cancer treatment. Furthermore the nanoparticles were connected to pH-sensitive complexes, enabling a pH-controlled assembly/disassembly and therefore the spreading of the particles in the tissue. With this novel method of combining detection and treatment simultaneously, the amount of medical exposure could be minimized for the patient. The results demonstrate that magnetite nanoparticles can effectively be functionalized with PET isotopes and pH sensitive complexes in order to use them as a new type of radiopharmaceuticals.

The role of 99mTc-sestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis

The wide availability and the extensive use of screening mammography have resulted in an earlier diagnosis of breast cancer and in a significant reduction in the relative risk of dying from this disease. Despite technical improvements and major advantages associated with the use of mammography (and breast ultrasound), this procedure has some limitations in clinical practice, especially in women with dense breast tissue, implants, severe dysplastic disease, or significant architectural distortion following breast surgery or radiation therapy. Different noninvasive imaging techniques have been evaluated to overcome these limitations. Nuclear medicine also has been actively involved in the detection of breast cancer, using various types of radiopharmaceuticals. Currently, there are three radiotracers commonly used for breast imaging or scintimammography in either clinical practice or research: 99mTc-sestamibi and 99mTc-tetrofosmin (two agents used for myocardial perfusion imaging) and 99mTc-MDP (methylene diphosphonate, used for bone scintigraphy). 99mTc-sestamibi was the first radiopharmaceutical to be approved by the FDA for scintimammography. Several prospective studies have shown that the overall sensitivity of 99mTc-sestamibi scintimammography in detection of breast cancer was 85%, the specificity was 89%, and the positive and negative predictive values were 89% and 84% respectively. Similar numbers have been demonstrated for 99mTc-tetrofosmin and 99mTc-MDP scintimammography. Although not indicated as a screening procedure for the detection of breast cancer, scintimammography may play a useful and significant role in various specific clinical indications such as nondiagnostic or difficult mammography, and evaluation of high-risk patients, tumor response to chemotherapy, and axillary lymph node metastatic involvement.

In vivo diagnostic nuclear medicine. Pediatric experience.

The use of radiopharmaceuticals for diagnostic tests in children is increasing and interest in these is evidenced by the addition of scientific sessions devoted to pediatric medicine at annual meetings of The Society of Nuclear Medicine and by the increase in the literature on pediatric dosimetry. Data presented in this paper describe the actual pediatric nuclear medicine experience from 26 nationally representative U.S. hospitals and provide an overview of the pediatric procedures being performed the types of radiopharmaceuticals being used, and the activity levels being administered.

Technetium-99m radiopharmaceuticals--a survey of various commercial kits.

SUMMARY A number of commercially available technetium-99m labelling kits have been evaluated. The study covers six different types of radiopharmaceuticals which were tested in combination with 99mTc-pertechnetate obtained from three different makes of generators. The labelling yield of the final products was determined by chromatography. In most single cases, acceptable labelling efficiency was obtained and the deterioration in quality by storage was negligible.