One approach to ultrasound therapy is to use therapeutic agents that can be activated by focused ultrasound when they reach a specific site in the body. Commonly, such agents are loaded on the surfaces of microbubbles, which respond strongly to ultrasound and shed the payload. However, microbubbles require high pressures and mechanical indices to burst (typically above 200 kPa, MI > 0.2). Moreover, the quantity and types of therapeutic payload that can be delivered by microbubbles are limited because payloads must be attached to the microbubble surface. Here, we show how these limitations can be overcome by using stabilized antibubbles as an ultrasound-responsive carrier. Antibubbles are liquid droplets encased within an air bubble. Because therapeutic payloads can be encapsulated in the core, larger volumes can be carried per antibubble. Additionally, by carrying payloads in the volume rather than on the surface, a wider variety of payloads can be carried. Through experiments we demonstrate that antibubbles respond strongly to ultrasound and can release payloads with pressures below 50 kPa (MI = 0.05) for certain formulations. By modifying the formulation, we show that the release pressure and temporal release profile can be tuned. Finally, we show that the bursting is highly selective in space, demonstrating that antibubbles can be used for precise delivery of payloads using shaped, low-intensity ultrasound fields.