Event Abstract Back to Event Late parietal positive waves to a subject’s own name in unresponsive patients Dominique Morlet1, 2*, I. Holeckova3, P. Ruby1, 2, J. B. Eichenlaub1, 2 and C. Fischer1, 2, 4 1 Inserm U821, Brain Dynamics and Cognition, France 2 Université Lyon 1, France 3 Medical Faculty Plzen, Charles IV University Prague, Czechia 4 Neurological Hospital, Department of Clinical Neurophysiology, France We report here a series of findings from passive oddball paradigms (tone bursts as standards and deviants) including the subject’s own name (SON) presented as a novel (p ≤ 0.03) in healthy awake subjects and in unresponsive patients. In a first experiment (15 healthy subjects), the SON was randomly uttered either by an unknown voice or by a familiar voice in the same stimulation block. Both types of novels elicited a large novelty P3 response, with slightly enhanced amplitudes in the late part of the wave for the familiar voice. The most important difference between the two types of novels was a late parietal positivity appearing after the novelty P3, only in response to the familiar voice. In a second experiment (12 healthy subjects), the SON uttered by an unknown voice and the SON uttered by a familiar voice were presented in separate blocks. Both novels elicited similar novelty P3 responses as in the first experiment, but no late parietal positivity could be observed in either condition. In a third experiment (11 healthy subjects), the SON and another unfamiliar proper name were uttered by an unknown voice and randomly presented in the same block. A large late parietal positive wave followed novelty P3 only in response to the SON. The passive oddball paradigm including only the SON uttered by an unknown voice was applied in 50 severe comatose patients on average 20 days after coma onset. The SON elicited a central-parietal P3 response in 21 of these patients, of whom 17 awoke within the next 3 months. In 12 patients (of whom 11 woke up), we observed an additional component with more pronounced parietal predominance, significantly prolonging the duration of the P3 response. These studies demonstrate that, in healthy subjects, the presence of late parietal positive waves in response to SON depends highly on the stimulation context. This result questions about the cognitive counterpart of these components. Moreover, late parietal positivities can also be observed in supposedly unconscious patients in whom they could highlight some cognitive activity. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: Morlet D, Holeckova I, Ruby P, Eichenlaub JB and Fischer C (2009). Late parietal positive waves to a subject’s own name in unresponsive patients. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.058 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Mar 2009; Published Online: 24 Mar 2009. * Correspondence: Dominique Morlet, Inserm U821, Brain Dynamics and Cognition, Lyon, France, dominique.morlet@inserm.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dominique Morlet I. Holeckova P. Ruby J. B Eichenlaub C. Fischer Google Dominique Morlet I. Holeckova P. Ruby J. B Eichenlaub C. Fischer Google Scholar Dominique Morlet I. Holeckova P. Ruby J. B Eichenlaub C. Fischer PubMed Dominique Morlet I. Holeckova P. Ruby J. B Eichenlaub C. Fischer Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.