ABSTRACTWe propose a research framework that expressly takes into account the moderating and differentiated influence that can be exerted on the dynamics of entrepreneurship capital by both the type of local system and the economic situation. Moreover, we investigate whether industrial districts are a more favourable context for the evolution of the entrepreneurship capital. We apply this framework to data of municipalities, grouped in local labour systems, of three Spanish regions and in two sub-periods of, respectively, crisis (2007–2011) and incipient recovery (2011–2014). Results are consistent with a set of sensible relations that can be extracted from the background literature.