The article comprehensively examines the issues related to the transformation of economic crime in the period of globalization and, in particular, the global impact of the COVID-19 pandemic. Arguments in favor of the author’s idea of ways to improve the mechanism of criminal law protection of the domestic economy in the face of new challenges. It is stated that in modern societies the emergence of new types of economic crimes, the growth of economic crime in general and its adaptation to various socio-economic changes. Globalization of crime, together with economic globalization, which serves, so to speak, as a general background, requires experts in the field of comparative criminal law to strengthen international cooperation and develop ways to address a number of issues related to combating criminal behavior that has long gone beyond boundaries of national criminal justice systems. The conclusion is reached that the year 2020 has brought new challenges to the modern connected world: the COVID-19 pandemic, which indirectly made nations unite in the face of a major healthcare threat; also, in a somewhat secondary mode, new forms of white collar criminal behavior, which spreads across the state borders is caused, either directly or indirectly, by the pandemic, and also a wide range of issues, related to national border protection modes. This requires law enforcement agencies to build up joint efforts in combatting new forms of white collar crime both on national and international levels.