Objective: We aim to compare the stone-free rate (SFR), complications, and re-treatment rates in retrograde intrarenal surgery (RIRS) using a traditional suction ureteral access sheath (SUAS) with the more advanced flexible and navigable suction UAS (FANS). Materials and methods: Retrospective analysis was performed on patients who underwent RIRS using SUAS versus FANS across five institutions internationally as part of an audit. We analysed baseline and pre-operative characteristics such as stone location and density, intra-operative characteristics such as type of ureteroscope and laser, laser, and fluoroscopy time, as well as post-operative complications and residual fragments (RFs). Results: A total of 45 patients were included in each arm, with no significant difference in baseline characteristics. The commonest sheath size in the FANS group was 10–12 Fr (64.4%), while 11–13 Fr was preferred in SUAS (73.3%). Despite similar lasers (thulium fibre laser (TFL) and high-power holmium laser with MOSES), stone dusting (48.9%) and popcorning (95.6%) were carried out in FANS with minimal need for baskets (4.4%), while popcorning (64.4%) and basket extraction (40.0%) were required in SUAS. Although FANS had significantly longer operative times (65 minutes versus 55 minutes), it also had significantly higher rates of 100% SFR (80.0% versus 13.3%), and lower rates of clinically significant residual fragment (CSRF) (8.9% versus 53.3%), clinically insignificant residual fragment (CIRF) (11.1% versus 33.3%), and reintervention for CSRF (4.4% versus 37.8%). In addition, minor complications such as intra-operative oozing from mucosa not requiring intervention (8.9% versus 31.1%) and post-operative fever (11.1% versus 40.0%) were less common in FANS. On additional multivariate analysis, FANS was the only significant factor for higher SFR. Discussion and conclusion: The results of our study demonstrate that with its flexible and navigable tip, FANS proves advantageous over SUAS in terms of improving immediate SFR with negligible complications. By navigating the sheath into targeted individual calyces, fragments and dust are more successfully aspirated. FANS can therefore help to achieve the trifecta of high single-stage SFR, minimal minor and no major complications, and negligible reintervention rates. Level of evidence: Not applicable.