Introduction: Breast cancer (carcinoma mammae) is a malignancy originating from breast tissue, either from its ductal or lobular epithelium. Objective: This study aims to find out the characteristics of Breast Cancer at Margono Soekarjo Hospital in Purwokerto to determine the breast cancer therapy policies. Methods : This study utilized a descriptive retrospective design with the research subjects being patients with carcinoma mammae who underwent anatomical pathology and immunohistochemistry examinations at Prof. Dr. Margono Soekarjo Regional General Hospital from 2020 to 2023. Result: The characteristics age of patients with Carcinoma Mammae are divided into 76 patients (30,9%) between 50-59 years old, followed by the 40-49 age group with 68 patients (27,6%). A total of 178 (72.4%) patients are ductal type, followed by 35 patients (14,2%) are lobular type. A total of 92 patients (37,4%) are grade 2 of Ca Mammae, followed by 83 patients (33,7%) are grade 3. A total of 95 patients (38,6%) are Luminal B sub type, followed by 69 patients (28%) are Her2 Enriched. Conclusion: The majority of breast cancer patient are aged 50 – 59 years with Invasive Ductal Carcinoma type, grade 2 and Luminal B Subtype.