Meropenem is used to treat bacterial causing infections like abdominal infections, skin bacterial). Meropenem is in a class of antibiotics. Skin eruption (or) skin rashes with meropenem is a rarely documented phenomenon that may be difficult in the contest of often complicated clinical presentation. Allergic reactions to antimicrobial are considered as type-B (adverse) reactionpharmacologically unpredictable non-dose dependent and often immune-mediated. Type B-reactions are further divided into type I through IV in the classification system. More of the patients were reported with type I (penicillin) allergy 2%risk to cyclosporine. <1% of carbapenems & 0% to monobactams, type-II (cytotoxic), type-III (immune complex) and type-IV (cell-mediated). Here we report a case of a young adult female with acute febrile illness with thrombocytopenia with bleeding manifestation and abdominal pain initiated with meropenem presented with non-blashing rashes throughout the primary week of treatment initiation. Stressing the importance of clinicians remaining alert for abnormal activity symptoms.