The X-ray transition edge sensor (TES) modeled by calorimeter is extremely sensitive to temperature changes when operating at a voltage bias in the temperature region, and is widely used for the detection of particles and photons from submicron frequency to gamma rays. Superconducting quantum interference device (SQUID) is the key to TES current signal readout, we have designed a two-stage SQUID amplifier circuit. First-stage sensor SQUID uses first-grade gradiometer with high input mutual inductance about 176.2 , it increases the coupling sensitivity with the TES detector and has stronger resistance to external interference. Second-stage SQUID array(SSA) adopts 32 single SQUIDs in series, which has low magnetic flux noise and high magnification. We have verified the characteristics of this two-stage circuit and demonstrated that it has a lower magnetic flux noise.