Background: The increasing use of pesticides is raising attention on the pervasiveness of contamination far from emission points and the pathways to human exposure. Recent progress in mapping global pesticide use can substantiate an assessment of human exposure and intake worldwide and the risks of attenuated life expectancy. Methods: We quantified the human intake ratio (INTR) relative to the acceptable level for 92 active substances. We intersected INTR with the Global Burden of Diseases (GBD) dataset, and we analysed the disability-adjusted life years (DALY) of both aggregated and individual non-communicable diseases (NCDs) against the INTR of major pesticide chemical classes. Using a stochastic two-stage regression analysis, we estimated the associations between pesticide INTR and DALYs, and we determined whether these associations were positive (i.e., adverse effect on life expectancy), uncertain, or negative. Findings: About 5.7 billion people exceed the acceptable pesticide intake; about 4.6 billion exceed this by 100 times. Pesticides are associated with DALYs of NCDs in 47% of countries; organophosphates, inorganics, triazines, and triazoles are associated with NCDs in 100%, 68%, 66% and 66% of countries, respectively. Prevalent NCDs are musculoskeletal disorders, neoplasms, and mental disorders in 72%, 62%, and 54% of countries. In average, an increase by one order in INTR is associated with a decrease of 1.35 days/person in neoplasms (95% CI, 0.27-2.48 days/person), and 1.09 days/person in musculoskeletal disorders (95% CI, 0.45-1.74 days/person). In spite of geographic variability, high income countries are more affected than low income countries due to raised health risk factors. Interpretation: Although the biological mechanisms determining health effects in human subjects remain largely undiscovered, statistically significant associations of chronic exposure to pesticide mixtures on various NCDs show the relative impact of different pesticide classes on exposed populations and indicate geographic regions, socioeconomic, and health indicators associated to risks of attenuated life expectancy. Funding Statement: The University of Sydney, SREI2020 EnviroSphere Program, SOAR Fellowship (FM). Declaration of Interests: The authors declare no competing interests.