In order to explore the influence of load and high temperature on the uniaxial compressive properties of desert sand concrete (DSC), the axial compressive strength test of desert sand concrete after different loads and temperatures was carried out, and the stress-strain curve was measured. The influence of load level, temperature grade and cooling method on the mass loss rate, ultrasonic velocity and uniaxial compressive performance of desert sand concrete after high temperature was analyzed. The results show that as the temperature increases, the mass loss rate of desert sand concrete gradually increases, the axial compressive strength gradually decreases, the peak strain increases significantly, the stress-strain curve tends to be flat, and the elastic modulus decreases continuously. The "pseudoplastic platform" near the axial compressive strength of the stress-strain curve of desert sand concrete after high temperature is more obvious. Based on the two-stage constitutive model of concrete, the constitutive model of desert sand concrete considering the influence of temperature and load level is established. The research results can provide technical support for the performance evaluation of desert sand concrete after high temperature.