The application of drones in last-mile distribution has been a contentious research topic in recent years. Existing urban distribution modes mostly depend on trucks. This paper proposes a novel package pickup and delivery mode and system wherein multiple drones collaborate with automatic devices. The proposed mode uses free areas on top of residential buildings to set automatic devices as delivery and pickup points of packages, and employs drones to transport packages between buildings and depots. The integrated scheduling problem of package drop-pickup considering <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</i> -drones, <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</i> -depots, and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</i> -customers is crucial for the system. Therefore, we propose a simulated-annealing-based two-phase optimization (SATO) approach to solve this problem. In the first phase, tasks are allocated to depots for serving, such that the initial problem is decomposed into multiple single-depot scheduling problems with <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</i> -drone. In the second phase, considering the drone capability and task demand constraints, we generated a route-planning scheme for drones in each depot. Concurrently, an improved variable neighborhood descent (IVND) algorithm was designed in the first phase to reallocate tasks, and a local search (LS) algorithm was proposed to search for high-quality solutions in the second phase. Finally, extensive experiments and comparative studies were conducted to verify the effectiveness of the proposed approach.
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