Supernova (SN) 1987A focused attention on the critical role of hydrodynamic instabilities in the evolution of supernovae. To test the modeling of these instabilities, we are developing laboratory experiments of hydrodynamic mixing under conditions relevant to supernovae. Initial results were reported in J. Kane et al. [Astrophys. J. 478, L75 (1997) and B. A. Remington et al., Phys. Plasmas 4, 1994 (1997)]. The Nova laser is used to generate a 10–15 Mbar shock at the interface of a two-layer planar target, which triggers perturbation growth due to the Richtmyer–Meshkov instability, and to the Rayleigh–Taylor instability as the interface decelerates. This resembles the hydrodynamics of the He-H interface of a Type II supernova at intermediate times, up to a few ×103 s. The scaling of hydrodynamics on microscopic laser scales to the SN-size scales is presented. The experiment is modeled using the hydrodynamics codes HYADES [J. T. Larson and S. M. Lane, J. Quant. Spect. Rad. Trans. 51, 179 (1994)] and CALE [R. T. Barton, Numerical Astrophysics (Jones and Bartlett, Boston, 1985), pp. 482–497], and the supernova code PROMETHEUS [P. R. Woodward and P. Collela, J. Comp. Phys. 54, 115 (1984)]. Results of the experiments and simulations are presented. Analysis of the spike-and-bubble velocities using potential flow theory and Ott thin-shell theory is presented, as well as a study of 2D versus 3D differences in perturbation growth at the He-H interface of SN 1987A.