The scheduling technology of regional integrated energy system is one of the key technologies to realize carbon neutralization by utilizing wind-power. Aiming at the optimal scheduling problem of regional electrothermal integrated energy system considering wind-power utilization and load side energy consumption, this paper proposes an optimized demand-response operation method of regional integrated energy system considering 5G base station energy storage. The regional integrated energy system of load side demand response is constructed based on the comprehensive consideration of technical and economic factors such as wind-power utilization and economic costs and load side peak valley difference. Finally, a two-layer particle swarm optimization method is proposed to solve the model. The experimental results show that the proposed method can effectively achieve wind-power utilization, economic dispatch and reduce the peak valley difference through load side demand response, which can improve the economic efficiency, environmental protection and low-carbon operation of regional integrated energy system.