We show that effective coupling strengths between ungapped and gapped quarks in the two-flavor color superconducting (2SC) phase are renormalized by logarithmic quantum corrections. We obtain a set of coupled renormalization-group (RG) equations for two distinct effective coupling strengths arising from gluon exchanges carrying different color charges. The diagram of RG flow suggests that both of the coupling strengths evolve into a strong-coupling regime as we decrease the energy scale toward the Fermi surface. This is a characteristic behavior observed in the Kondo effect, which has been known to occur in the presence of impurity scatterings via non-Abelian interactions. We propose a novel Kondo effect emerging without doped impurities, but with the gapped quasiexcitations and the residual SU(2) color subgroup intrinsic in the 2SC phase, which we call the 2SC Kondo effect.