<sec>Rogue wave is a kind of natural phenomenon that is fascinating, rare, and extreme. It has become a frontier of academic research. The rogue wave is considered as a spatiotemporal local rational function solution of nonlinear wave model. There are still very few (2 + 1)-dimensional nonlinear wave models which have rogue wave solutions, in comparison with soliton and Lump waves that are found in almost all (2 + 1)-dimensional nonlinear wave models and can be solved by different methods, such as inverse scattering method, Hirota bilinear method, Darboux transform method, Riemann-Hilbert method, and homoclinic test method. The structure and evolution characteristics of the obtained (2 + 1)-dimensional rogue waves are quite different from the prototypes of the (1 + 1)-dimensional nonlinear Schrödinger equation. Therefore, it is of great value to study two-dimensional rogue waves.</sec><sec>In this paper, the non-autonomous Kadomtsev-Petviashvili equation is first converted into the Kadomtsev-Petviashvili equation with the aid of a similar transformation, then two-dimensional rogue wave solutions represented by the rational functions of the non-autonomous Kadomtsev-Petviashvili equation are constructed based on the Lump solution of the first kind of Kadomtsev-Petviashvili equation, and their evolutionary characteristics are illustrated by images through appropriately selecting the variable parameters and the dynamic stability of two-dimensional single rogue waves is numerically simulated by the fast Fourier transform algorithm. The obtained two-dimensional rogue waves, which are localized in both space and time, can be viewed as a two-dimensional analogue to the Peregrine soliton and thus are a natural candidate for describing the rogue wave phenomena. The method presented here provides enlightenment for searching for rogue wave excitation of (2 + 1)-dimensional nonlinear wave models.</sec><sec>We show that two-dimensional rogue waves are localized in both space and time which arise from the zero background and then disappear into the zero background again. These rogue-wave solutions to the non-autonomous Kadomtsev-Petviashvili equation generalize the rogue waves of the nonlinear Schrödinger equation into two spatial dimensions, and they could play a role in physically understanding the rogue water waves in the ocean.</sec>
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