We study the ground-state lifetime (GSL) of polaron in a two-dimensional RbCl quantum pseudodot (QPD) system by using a variational method of Pekar type (PTVM) and the quantum statistical theory. Considering the polaron effect, we derive the dependent relations of the temperature, the electric field, the chemical potential (CP) of the two-dimensional electron gas (TDEG), the polaron radius (PR) and the zero point (ZP) of the pseudoharmonic potential (PHP) on the GSL of polaron. The calculated results show that the GSL $$\tau$$ of polaron will decrease when the CP $$V_{0}$$ of the TDEG, the electric field and the PR $$R_{p}$$ increase, but will increase while the ZP $$r_{0}$$ of the PHP, the ground-state energy (GSE) and the temperature parameter $$\gamma$$ become larger, respectively. That means that by changing the electric field, the temperature, the PR, the CP of the TDEG and the ZP of the PHP, one can adjust the GSL of polaron, which may offer new insight into studying many related applications in quantum computation (QC) and control of electron transition.