The significance of this investigation is to optimize the heat transfer rate of magnetohydrodynamic bioconvective hybrid nanofluid flow in the presence of heat source and thermal convection. The main focus is to examine the two-dimensional incompressible MHD and / hybrid nanofluid flow across the stretching cylinder with the Cattaneo–Christov heat flux model. The response surface methodological approach and sensitivity analysis have been employed to statistically scrutinize the influences of concentration, bioconvection, and thermo-diffusion on heat transfer rate. By applying suitable similarity vectors in controlling the partial differential equations, a system of equations (ODEs) is formed. A well-known method Runge Kutta with shooting has used for numerical simulations. The role of various involving factors on heat and mass transfer rate and skin friction factor is illustrated using tables, figures, and surface plots. The three-dimensional graphs displayed the synchronized effect of involving factors on physical quantities. The heat transfer rate is least responsive to variations in the magnetic parameter and most sensitive to the fluctuations of the Biot number. It is perceived that the nanoparticle concentration and motile concentration profiles declined with the increasing effect of chemical reaction parameters. The legitimacy of the current conclusions is established by the excellent agreement concerning present and previous consequences.
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