Abstract The hydrodynamic performance of waterjet propulsion pumps has an important impact on improving the speed of waterjet propulsion ships. High-precision prediction of the hydrodynamic performance of water-jet propulsion pumps based on CFD is of great significance to improving the pump design quality. Based on the Reynolds-averaged Naiver-Stokes equation, this paper conducts a grid-independence verification on a water jet propulsion pump based on hydrodynamic test data, uses the Latin hypercube sampling method to generate SST k-ω turbulence model parameter space calculation samples, performs steady-state calculation on all samples, analyzes the sensitivity of changes in the parameters of the turbulence model to the prediction of the external characteristics of the waterjet propulsion pump, and finally obtains the influence of changes in the parameters of the turbulence model on the prediction of the external characteristics of the pump. Among them, the sensitivities of the three parameters β *, β1 and a1 are higher. The results show that the prediction accuracy of the external characteristics of the water jet propulsion pump can be effectively improved by correcting these three highly sensitive parameters, and the correction values of the three key parameters are obtained. The prediction error of the external characteristics of the water jet propulsion pump is reduced from 4.3% to less than 2.1%. A feedforward neural network is used to establish a mapping model between the three turbulence model parameters and the head coefficient and power coefficient of the waterjet propulsion pump in order to achieve rapid prediction. The genetic algorithm is applied to optimize the weights, thresholds and other coefficients in the neural network, thereby improving the prediction accuracy. Based on the optimized neural network, the genetic algorithm is used to optimize the three turbulence model parameters, and the optimized coefficients are obtained. The optimized turbulence model parameters are put into the hydrodynamic model for RANS simulation to verify the degree of optimization of the model coefficients by the genetic algorithm.