The potential for ammonia/hydrogen (NH3/H2) blends as fuel in modern, turbocharged, gas engines is evaluated by comparing the combustion properties of these blends with those of methane. To ensure proper combustion phasing in existing spark-ignited (SI) engines, the laminar burning velocity (LBV) is used, while the ignition delay times (IDT) of the mixtures are compared to assess the risk of engine knock. The chemical mechanisms used for the computation of IDT and/or LBV of NH3/H2 mixtures are selected from 8 chemical mechanisms based on their ability to predict experimental data. The application of a turbocharger is shown to “boost” the temperature in the cylinder after compression to values that admit the use of NH3/H2 mixtures in natural-gas SI engines without increasing the compression ratio (CR). The analysis also identifies regions of temperature and H2 fraction that increase the risk of knock. Using the conditions in a practical turbocharged SI engine as an example, 40–50% H2 in NH3 yields combustion phasing equivalent to that obtained with methane, while avoiding the risk of knock. Analysis of the IDT for the conditions in a high-pressure direct-injection natural-gas engine also shows that the use of a turbocharger in compression-ignition (diesel-type) engines strongly reduces the demands on CR for achieving the conditions necessary for reliable ignition of NH3/H2 mixtures. Increasing the temperature by only a few tens of degrees above the conditions studied will yield an IDT for ∼20% H2 in NH3 that satisfies the ignitibility requirements for use in a turbocharged diesel engine.