This paper presents the turbine blade leading edge model film cooling effectiveness with shaped holes, using the pressure sensitive paint (PSP) mass transfer analogy method. The effects of leading edge profile, coolant to mainstream density ratio, and blowing ratio are studied. Computational simulations are performed using the realizable k–ɛ (RKE) turbulence model. Effectiveness obtained by computational fluid dynamics (CFD) simulations is compared with experiments. Three leading edge profiles, including one semicylinder and two semi-elliptical cylinders with an after body, are investigated. The ratios of major to minor axis of two semi-elliptical cylinders are 1.5 and 2.0, respectively. The leading edge has three rows of shaped holes. For the semicylinder model, shaped holes are located at 0 deg (stagnation line) and ±30 deg. Row spacing between cooling holes and the distance between impingement plate and stagnation line are the same for three leading edge models. The coolant to mainstream density ratio varies from 1.0 to 1.5 and 2.0, and the blowing ratio varies from 0.5 to 1.0 and 1.5. Mainstream Reynolds number is about 100,000 based on the diameter of the leading edge cylinder, and the mainstream turbulence intensity is about 7%. The results provide an understanding of the effects of leading edge profile on turbine blade leading edge region film cooling with shaped hole designs.