A multi-fidelity simulation method of external and internal flow has been developed using commercial software to achieve a smooth thrust of the turbine-based combined-cycle (TBCC) propulsion system. This platform enables the investigation of the flow field and performance of the TBCC propulsion system at different mode transition schemes. The integrated multi-fidelity simulation includes the inlet, turbojet engine, ramjet engine, and nozzle, providing insights into the operation process of the TBCC propulsion system during the transition from turbojet mode to ramjet mode. Three mode transition schemes are proposed: critical mode transition, constant aerodynamic interface plane (AIP) Mach number mode transition, and linear mode transition. From the perspective of TBCC inlet, the performance of the critical mode transition exhibits the best performance among these mode transition schemes, while the linear mode transition performs the worst. However, from the viewpoint of the TBCC propulsion system and the hypersonic vehicle, the performance of constant AIP Mach number mode transition is the best. The non-dimensional thrust increases almost linear from 1.0 to 1.2, enabling hypersonic vehicle to accelerate steadily during the transition from turbojet mode to ramjet mode.