Tunable System Research Articles

Active plasmonic nanodevices: From basic principles to emerging applications

AbstractTunable plasmonics has shown a wide range of applications in (bio)chemical sensing, displays, actuators, photonic chips, biomedicine, etc. in the last 2 decades. This review focuses on their recent development from the device perspective, which involves the understanding of fundamental principles and specific applications with desired functionality and compatibility. We classify these active plasmonic devices based on the nature of their structures and working environment as colloidal‐based, chip‐based, and colloidal chip‐based to further elaborate their performance and functions. We also highlight recent progress on tunable surface‐enhanced Raman spectroscopy, metasurfaces, and chiroptics to show the emerging applications of tunable plasmonic systems. We conclude this review with a general perception of the research trend in this field and challenges for their practical applications.

A tuneable minimal cell membrane reveals that two lipid species suffice for life

All cells are encapsulated by a lipid membrane that facilitates their interactions with the environment. How cells manage diverse mixtures of lipids, which dictate membrane property and function, is experimentally challenging to address. Here, we present an approach to tune and minimize membrane lipid composition in the bacterium Mycoplasma mycoides and its derived ‘minimal cell’ (JCVI-Syn3A), revealing that a two-component lipidome can support life. Systematic reintroduction of phospholipids with different features demonstrates that acyl chain diversity is more important for growth than head group diversity. By tuning lipid chirality, we explore the lipid divide between Archaea and the rest of life, showing that ancestral lipidomes could have been heterochiral. However, in these simple organisms, heterochirality leads to impaired cellular fitness. Thus, our approach offers a tunable minimal membrane system to explore the fundamental lipidomic requirements for life, thereby extending the concept of minimal life from the genome to the lipidome.

Tunable and dynamic nanophotonics: introduction

In this introduction, we provide an overview of the papers that were accepted for publication in the feature issue “Tunable and dynamic nanophotonics” of the Journal of the Optical Society of America B. The feature issue contains 10 articles on cutting-edge topics in the field of tunable nanophotonic systems.

Disassembling one-dimensional chains in molybdenum oxides

Abstract The dimensionality of quantum materials strongly affects their physical properties. Although many emergent phenomena, such as charge-density wave and Luttinger liquid behavior, are well understood in one-dimensional (1D) systems, the generalization to explore them in higher dimensional systems is still a challenging task. In this study, we aim to bridge this gap by systematically investigating the crystal and electronic structures of molybdenum-oxide family compounds, where the contexture of 1D chains facilitates rich emergent properties. While the quasi-1D chains in these materials share general similarities, such as the motifs made up of MoO6 octahedrons, they exhibit vast complexity and remarkable tunability. We disassemble the 1D chains in molybdenum oxides with different dimensions and construct effective models to excellently fit their low-energy electronic structures obtained by ab initio calculations. Furthermore, we discuss the implications of such chains on other physical properties of the materials and the practical significance of the effective models. Our work establishes the molybdenum oxides as simple and tunable model systems for studying and manipulating the dimensionality in quantum systems.

Tunable magnonic crystal in a hybrid superconductor–ferrimagnet nanostructure

One of the most intriguing properties of magnonic systems is their reconfigurability, where an external magnetic field alters the static magnetic configuration to influence magnetization dynamics. In this paper, we present an alternative approach to tunable magnonic systems. We studied theoretically and numerically a magnonic crystal induced within a uniform magnetic layer by a periodic magnetic field pattern created by the sequence of superconducting strips. We showed that the spin-wave spectrum can be tuned by the inhomogeneous stray field of the superconductor in response to a small uniform external magnetic field. Additionally, we demonstrated that modifying the width of superconducting strips and separation between them leads to the changes in the internal field which are unprecedented in conventional magnonic structures. The paper presents the results of semi-analytical calculations for realistic structures, which are verified by finite-element method computations.

A tuneable minimal cell membrane reveals that two lipid species suffice for life.

All cells are encapsulated by a lipid membrane which facilitates the interaction between life and its environment. How life exploits the diverse mixtures of lipids that dictate membrane property and function has been experimentally challenging to address. We introduce an approach to tune and minimize lipidomes in Mycoplasma mycoides and the Minimal Cell (JCVI-Syn3A) revealing that a 2-component lipidome can support life. Systematically reintroducing phospholipid features demonstrated that acyl chain diversity is more critical for growth than head group diversity. By tuning lipid chirality, we explored the lipid divide between Archaea and the rest of life, showing that ancestral lipidomes could have been heterochiral. Our approach offers a tunable minimal membrane system to explore the fundamental lipidomic requirements for life, thereby extending the concept of minimal life from the genome to the lipidome.

Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications.

Complex coacervates, formed through electrostatic interactions between oppositely charged polymers, present a versatile platform for drug delivery, providing rapid assembly, selective encapsulation, and responsiveness to environmental stimuli. The architecture and properties of coacervates can be tuned by controlling structural and environmental design factors, which significantly impact the stability and delivery efficiency of the drugs. While environmental design factors such as salt, pH, and temperature play a crucial role in coacervate formation, structural design factors such as polymer concentration, polymer structure, mixing ratio, and chain length serve as the core framework that shapes coacervate architecture. These elements modulate the phase behavior and material properties of coacervates, allowing for a highly tunable system. In this review, we primarily analyze how these structural design factors contribute to the formation of diverse coacervate architecture, ranging from bulk coacervates to polyion complex micelles, vesicles, and cross-linked gels, though environmental design factors are considered. We then examine the effectiveness of these architectures in enhancing the delivery and efficacy of drugs across various administration routes, such as noninvasive (e.g., oral and transdermal) and invasive delivery. This review aims to provide foundational insights into the design of advanced drug delivery systems by examining how the origin and chemical structure of polymers influence coacervate architecture, which in turn defines their material properties. We then explore how the architecture can be tailored to optimize drug delivery for specific administration routes. This approach leverages the intrinsic properties derived from the coacervate architecture to enable targeted, controlled, and efficient drug release, ultimately enhancing therapeutic outcomes in precision medicine.

Direct M2 macrophage co-culture overrides viscoelastic hydrogel mechanics to promote fibroblast activation.

Fibroblast activation drives fibrotic diseases such as pulmonary fibrosis. However, the complex interplay of how tissue mechanics and macrophage signals combine to influence fibroblast activation is not well understood. Here, we use hyaluronic acid hydrogels as a tunable cell culture system to mimic lung tissue stiffness and viscoelasticity. We applied this platform to investigate the influence of macrophage signaling on fibroblast activation. Fibroblasts cultured on stiff (50 kPa) hydrogels mimicking fibrotic tissue exhibit increased activation as measured by spreading as well as type I collagen and cadherin-11 expression compared to fibroblasts cultured on soft (1 kPa) viscoelastic hydrogels mimicking normal tissue. These trends were unchanged in fibroblasts cultured with macrophage-conditioned media. However, fibroblasts directly co-cultured with M2 macrophages show increased activation, even on soft viscoelastic hydrogels that normally suppress activation. Inhibition of interleukin 6 (IL6) signaling does not change activation in fibroblast-only cultures but ameliorates the pro-fibrotic effects of M2 macrophage co-culture. These results underscore the ability of direct M2 macrophage co-culture to override hydrogel viscoelasticity to promote fibroblast activation in an IL6-dependent manner. This work also highlights the utility of using hydrogels to deconstruct complex tissue microenvironments to better understand the interplay between microenvironmental mechanical and cellular cues.

Excitonic Bose Polarons in Electron-Hole Bilayers.

Bose polarons are mobile particles of one kind dressed by excitations of the surrounding degenerate Bose gas of particles of another kind. These many-body objects have been realized in ultracold atomic gases and become a subject of intensive studies. In this work, we show that excitons in electron-hole bilayers offer new opportunities for exploring polarons in strongly interacting, highly tunable bosonic systems. We found that Bose polarons are formed by spatially direct excitons immersed in degenerate Bose gases of spatially indirect excitons (IXs). We detected both attractive and repulsive Bose polarons by measuring photoluminescence excitation spectra. We controlled the density of IX Bose gas by optical excitation and observed an enhancement of the energy splitting between attractive and repulsive Bose polarons with increasing IX density, in agreement with our theoretical calculations.

Liquid Crystal Enables Extraordinarily Precise Tunability for a High‐Q Ultra‐Narrowband Filter Based on a Quasi‐BIC Metasurface

AbstractNotch filters usually involve high costs, great difficulties in processing, and very limited tunability. By coating a nematic liquid crystal (LC) layer onto a well‐designed quasi‐bound states in the continuum (quasi‐BICs) metasurface, this work designs and demonstrates a high‐Q tunable filtering system with precise tunability in the near‐infrared spectral range. Optimal structural parameters and the filtering performance are first determined by numerical simulations and then confirmed in experiments. The precise tunability is enabled by modifying the LC molecules’ principal axes with an applied voltage, where the least distinguishable central wavelength interval is smaller than 0.3 nm, and the largest Q factor extracted from experiments can be ≈256.1. Compared to most of the commercial notch filters that work in the visible region and have no tunability, this work achieves an ultra‐narrowband filtering system that features low manufacture difficulty and cost, and great control of light propagation. The proposed design also opens new avenues for developing BIC‐based high‐Q devices with enhanced signal‐to‐noise ratio and multifunctional properties.

Fuel-Driven Dynamic Combinatorial Peptide Libraries.

Dynamic combinatorial chemistry (DCC) creates libraries of molecules that are constantly interchanging in a dynamic combinatorial library. When a library member self-assembles, it can displace the equilibria, leading to emergent phenomena like its selection or even its replication. However, such dynamic combinatorial libraries typically operate in or close to equilibrium. This work introduces a new dynamic combinatorial chemistry fueled by a catalytic reaction cycle that forms transient, out-of-equilibrium peptide-based macrocycles. The products in this library exist out of equilibrium at the expense of fuel and are thus regulated by kinetics and thermodynamics. By creating a chemically fueled dynamic combinatorial library with the vast structural space of amino acids, we explored the liquid-liquid phase separation behavior of the library members. The study advances DCCs by showing that peptide structures can be engineered to control the dynamic library's behavior. The work paves the way for creating novel, tunable material systems that exhibit emergent behavior reminiscent of biological systems. These findings have implications for the development of new materials and for understanding life's chemistry.

Effects of dim-evening lighting optimised for geographical orientation versus standard lighting on mental health: protocol paper for a quasiexperimental study in a psychiatric hospital

IntroductionResearch has provided novel insights into how light stimulates circadian rhythms through specialised retinal ganglion cells to the suprachiasmatic nucleus. In addition, there has been a revolution in light-emitting diode...

Moiré-engineered light-matter interactions in MoS2/WSe2 heterobilayers at room temperature

Moiré superlattices in van der Waals heterostructures represent a highly tunable quantum system, attracting substantial interest in both many-body physics and device applications. However, the influence of the moiré potential on light-matter interactions at room temperature has remained largely unexplored. In our study, we demonstrate that the moiré potential in MoS2/WSe2 heterobilayers facilitates the localization of interlayer exciton (IX) at room temperature. By performing reflection contrast spectroscopy, we demonstrate the importance of atomic reconstruction in modifying intralayer excitons, supported by the atomic force microscopy experiment. When decreasing the twist angle, we observe that the IX lifetime becomes longer and light emission gets enhanced, indicating that non-radiative decay channels such as defects are suppressed by the moiré potential. Moreover, through the integration of moiré superlattices with silicon single-mode cavities, we find that the devices employing moiré-trapped IXs exhibit a significantly lower threshold, one order of magnitude smaller compared to the device utilizing delocalized IXs. These findings not only encourage the exploration of many-body physics in moiré superlattices at elevated temperatures but also pave the way for leveraging these artificial quantum materials in photonic and optoelectronic applications.

Tunable, self-contained gene dosage control via proteolytic cleavage of CRISPR-Cas systems.

Gene therapy holds great therapeutic potential. Yet, controlling cargo expression in single cells is limited due to the variability of delivery methods. We implement an incoherent feedforward loop based on proteolytic cleavage of CRISPR-Cas activation or inhibition systems to reduce gene expression variability against the variability of vector delivery. We demonstrate dosage control for activation and inhibition, post-delivery tuning, and RNA-based delivery, for a genome-integrated marker. We then target the RAI1 gene, the haploinsufficiency and triplosensitivity of which cause two autism-related syndromes, Smith-Magenis-Syndrome (SMS) and Potocki-Lupski-Syndrome, respectively. We demonstrate dosage control for RAI1 activation in HEK293s, Neuro-2As, and mouse cortical neurons via AAVs and lentiviruses. Finally, we activate the intact RAI1 copy in SMS patient-derived cells to an estimated two-copy healthy range, avoiding the harmful three-copy regime. Our circuit paves the way for viable therapy in dosage-sensitive disorders, creating precise and tunable gene regulation systems for basic and translational research.

Tunable Acoustic Tweezer System for Precise Three-Dimensional Particle Manipulation

This study introduces a tunable acoustic tweezer system designed for precise three-dimensional particle trapping and manipulation. The system utilizes a dual-liquid-layer acoustic lens, which enables the dynamic control of the focal length through the adjustable curvature of a latex membrane. This tunability is essential for generating the acoustic forces necessary for effective manipulation of particles, particularly along the direction of acoustic wave propagation (z-axis). Experiments conducted with spherical particles as small as 1.5 mm in diameter demonstrated the system’s capability for stable trapping and manipulation. Performance was rigorously evaluated through both z-axis and 3D manipulation tests. In the z-axis experiments, the system achieved a manipulation range of 33.4–53.4 mm, with a root-mean-square error and standard deviation of 0.044 ± 0.045 mm, which highlights its precision. Further, the 3D manipulation experiments showed that particles could be accurately guided along complex paths, including multilayer rectangular and helical trajectories, with minimal deviation. A visual feedback-based particle navigation system significantly enhanced positional accuracy, reducing errors relative to open-loop control. These results confirm that the tunable acoustic tweezer system is a robust tool for applications requiring precise control of particles with diameter of 1.5 mm in three-dimensional environments. Considering its ability to dynamically adjust the focal point and maintain stable trapping, this system is well suited for tasks demanding high precision, such as targeted particle delivery and other applications involving advanced material manipulation.

Nonlinear behavior and energy harvesting performance of a new tunable quasi-zero stiffness system.

Energy harvesting from vibrations is a popular research topic. However, it is difficult to change the values of its dynamic stiffness characteristics during the operation of device. This paper analyzes the nonlinear dynamical behavior and energy harvesting performance of an energy harvesting device with a gear unit and an inertial amplifier. The Melnikov method is used to discriminate the chaos behavior of the system and is illustrated by numerical simulations. Chaotic dynamics analysis provides a simplified analytical idea that offers more insight into the performance of this energy harvesting device. In addition, the basins of attraction of the coexistence solution of the system are plotted, and the trajectory and energy harvesting efficiency of the system are analyzed for changes in the initial value. The results show that the device has the convenience to change the form and efficiency of system energy harvesting. The theory of Melnikov functions recognizes the presence of chaos and can provide solutions for the parameterization of the system. The choice of initial value greatly affects the energy harvesting efficiency.

Electrical spectroscopy of polaritonic nanoresonators

One of the most captivating properties of polaritons is their capacity to confine light at the nanoscale. This confinement is even more extreme in two-dimensional (2D) materials. 2D polaritons have been investigated by optical measurements using an external photodetector. However, their effective spectrally resolved electrical detection via far-field excitation remains unexplored. This hinders their exploitation in crucial applications such as sensing, hyperspectral imaging, and optical spectrometry, banking on their potential for integration with silicon technologies. Herein, we present the electrical spectroscopy of polaritonic nanoresonators based on a high-quality 2D-material heterostructure, which serves at the same time as the photodetector and the polaritonic platform. Subsequently, we electrically detect these mid-infrared resonators by near-field coupling to a graphene pn-junction. The nanoresonators simultaneously exhibit extreme lateral confinement and high-quality factors. This work opens a venue for investigating this tunable and complex hybrid system and its use in compact sensing and imaging platforms.

Enhanced four-band absorption in a tunable graphene subwavelength grating structure for photodetection

This paper investigates a sub-wavelength multilayer dielectric grating structure based on a simple metasurface, achieving dynamically switchable four-band absorption enhancement. This enhancement spans the visible to near-infrared (NIR) range, with absorption exceeding 90%, representing nearly a 40-fold increase over the intrinsic absorption of a single graphene layer. The contributions of guided-mode resonance (GMR), optical Tamm state (OTS), and photonic crystal defect cavity resonance to the absorption spectra are analyzed separately, offering a method for independent multi-channel signal extraction. Additionally, we explore the impact of structural parameters on the absorption response and examine the broad-spectrum multiband detection mechanism. This mechanism, explained through the integration of resonant cavity perturbation theory and the dynamic tuning of absorption efficiency via graphene's Fermi energy levels, results in an independently tunable optical system for four key operating bands. These properties make the structure suitable for applications such as multiband biomedical photodetectors or components in optoelectronic devices with multiple operating bands.

LAVOLUTION: Tunable structured light for bridge displacement measurement

Assessing bridge conditions is critical, but field measurements often face challenges like sensor installation and accuracy requirements. This paper introduces a novel approach using structured light (SL) for non-target-based measurements, eliminating the need for physical markers. A tunable SL system, featuring four laser pointers aligned with a commercial camera, was developed to estimate the relative angle between the camera and the target structure, and to accurately calculate the scale factor. The proposed method involves three main processes: (1) laser alignment, (2) angle estimation, and (3) real-time displacement measurement. By precisely aligning the SL system and minimizing discrepancies between projected SL points and an ideal numerical model, the method achieves accurate results. Validation through numerical simulations, lab-scale tests, and full-scale bridge tests demonstrated a maximum error of 2.69% in scale and 2.53% in displacement, confirming the method’s effectiveness and applicability.

Vacancy-Induced Tunable Kondo Effect in Twisted Bilayer Graphene.

In single sheets of graphene, vacancy-induced states have been shown to host an effective spin-1/2 hole that can be Kondo screened at low temperatures. Here, we show how these vacancy-induced impurity states survive in twisted bilayer graphene (TBG), which thus provides a tunable system to probe the critical destruction of the Kondo effect in pseudogap hosts. Abinitio calculations and atomic-scale modeling are used to determine the nature of the vacancy states in the vicinity of the magic angle in TBG, demonstrating that the vacancy can be treated as a quantum impurity. Utilizing this insight, we construct an Anderson impurity model with a TBG host that we solve using the numerical renormalization group combined with the kernel polynomial method. We determine the phase diagram of the model and show how there is a strict dichotomy between vacancies in the AA/BB versus AB/BA tunneling regions. In AB/BA vacancies, the Kondo temperature at the magic angle develops a broad distribution with a tail to vanishing temperatures due to multifractal wave functions at the magic angle. We argue that scanning tunneling microscopy in the vicinity of the vacancy can act as a probe of both the critical single-particle states and the underlying many-body ground state in magic-angle TBG.