Tunable Sensitivity Research Articles

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

The contractile nature of skeletal muscle tissue makes it especially attractive for powering biohybrid actuators. Significant efforts have been dedicated to the improvement and control of contraction force, going one step forward toward the automation of these biohybrid platforms. Herein, 3D‐bioengineered skeletal muscle tissues are integrated with organic transistor‐based sensors to define a soft bioactuator with real‐time force monitoring capabilities. The muscle tissue is electrically stimulated while the organic sensor ensures transduction of the exerted force into an electrical signal that allows direct monitoring of the bioactuator performance. Sensor calibration is carried out to define its sensitivity at different biasing conditions: as opposed to standard, two‐terminal piezoresistive devices, transistor‐based strain sensors show tunable sensitivity by acting on the voltage applied to a third terminal—the gate. A complete evaluation of sensing performances is provided, demonstrating that real‐time monitoring is effective under different conditions, including stimulation signal frequency and chemical modulation of the bioactuator contraction, demonstrating its potential use as a drug testing platform. In the reported results, the way is paved for a complete exploitation of organic devices in soft robotic applications and to the development of novel biohybrid machines in bioengineering and biomedicine.

Flexible tactile sensing of magnetic hydrogel composites based on electrical impedance tomography

Flexible and stretchable tactile sensors show promising applications in robotics, prosthetics, and wearable electronics. This paper demonstrates an electrical impedance tomography (EIT) based highly flexible, touch-sensitive pressure sensor using magnetic hydrogels. EIT technology has been explored for continuous distributed strain sensing and tactile imaging. Magnetic hydrogel composites are synthesized by simultaneous polymerization and crosslinking of acrylamide with magnetic carbonyl iron particles (CIPs). The effects of CIPs percentage on morphology, sensitivity, and electrical/mechanical properties is investigated. EIT accurately discerns pressure quantity, shape, and spatial distribution. Lower CIPs volume fractions (3%) exhibit maximum sensitivity to strain fields. Mechanical testing show the hydrogels have excellent fatigue resistance, ideal for repeated compression loading. The results demonstrate the potential of EIT with magnetic hydrogel composites for tactile sensing and imaging, with applications in soft robotics, prosthetics, and wearable electronics. The tunable sensitivity and multifunctionality make these soft composites promising materials for flexible electronics.

Robust Strain Sensor with High Sensitivity Based on Polymer-Encapsulated Microfiber Mach-Zehnder Interferometer.

A robust strain sensor is demonstrated based on a microfiber Mach-Zehnder interferometer (MMZI) encapsulated by the polymer polydimethylsiloxane (PDMS). Benefiting from the low Young's modulus of PDMS, both a robust structure and high sensitivity can be realized based on three different encapsulations. In the experiment, the proposed sensors are fabricated and tested with strain sensitivities ranging from -20.95 pm/με to 127.00 pm/με within the wavelength range of 1200-1650 nm. Compared with the bare MMZI sensor, at least one order of magnitude higher sensitivity is reached. To further evaluate the performance of the sensor, the dependences of sensitivity on probing wavelength and the different types and quantities of polymers used in encapsulation are discussed. Results show that the sensitivity of the sensor will increase with the probing wavelength. The type and quantity of polymer used are also very critical to sensitivity. Additionally, a response time of 24.72 ms can be reached. Good recoverability and repeatability of the sensor are also demonstrated by repeated experiments. The strain sensor demonstrated here shows the advantages of simple fabrication, robust structure, high and tunable sensitivity, fast response, good recoverability and repeatability.

Tunable Sensitivity in Graphene-Based Soil Moisture Sensors via Controlled Vapor Phase Reduction Method

Tunable Sensitivity in Graphene-Based Soil Moisture Sensors via Controlled Vapor Phase Reduction Method

Nanofluidic Thermoelectric Transducer with Ultrahigh and Tunable Sensitivity.

Thermosensitive transient receptor potential (thermoTRP) ion channels can transduce external thermal stimuli to neural electrical signals, allowing organisms to detect and respond to changes in environmental temperature. Reproducing such ionic machinery holds promise for advancing the design of highly efficient low-grade thermal energy harvesters and ultrasensitive thermal sensors. However, there still exist challenges for artificial nanofluidic architectures to achieve comparable thermoelectric performance. Here, we report nanofluidic thermoelectric transducers with ultrahigh and tunable sensitivities controlled by electrostatic gating in graphene nanochannels. The equivalent Seebeck coefficient can be significantly boosted and reaches 1 order of magnitude higher than the current state of the art, even beyond thermoTRP ion channels. The improvement is attributed to substantial slippage on the highly charged graphene surface, leading to enhanced electrokinetic ion transport inside the graphene channel, which is confirmed by a scaling theory for thermoelectric coupling as well as molecular dynamic simulations. The dependence of the nanofluidic thermoelectric on the concentration, channel size, and cation types is also investigated to further clarify the underlying mechanism.

Cooperative Control of Bioelectrocatalytic Activity for Thermo- and Photo-Switchable Cup-Stacked Carbon Nanofiber Electrodes Modified with Phase Transition Polymer and Heme Peptide.

Empowering biocatalyst-modified electrodes with the ability to both enforce and perceive will enable the development of intrinsically switchable bioelectrode systems, which exhibit autonomous and heteronomous actions specific to living organisms. However, the electrocatalytic activity of switchable bioelectrodes reported so far has been controlled by changes in the rate of substrate transport to biocatalysts. Here, we prepared a cup-stacked carbon nanofiber (CSCNF) electrode modified with a thermoresponsive N-isopropylacrylamide-based polymer containing peroxidase model compounds (HP). As CSCNFs worked as a converter from near-infrared (NIR) light to heat, bioelectrocatalytic activity of the electrode to H2O2 reduction was reversibly controlled by changes in the amount of electroactive HP, based on expanded and contracted states of the polymers induced by not only environmental temperature changes but also external NIR light irradiation. This intrinsically switchable bioelectrode technique would hold promise for adding new performances in electrochemical biosensors and biofuel cells, for example, autonomous and heteronomous tunable sensitivity and capacity.

Tunable Ultra‐Narrow Linewidth Light Source Through Liquid Crystal‐Assisted Mini‐Bound‐States‐In‐Continuum Cavities

AbstractThe introduction of liquid crystals into microcavities has garnered considerable attention for their exceptional tunability and high sensitivity to external perturbation factors within their distinct phase states. Here, a novel light source with both wavelength tunability and an exceptionally narrow linewidth is presented. This innovation is realized by strategically manipulating LC molecules, transitioning them from a well‐aligned state to a disordered state with increasing temperature. The microcavity is tailored to support bound states in the continuum, a cutting‐edge concept in photonic research that allows for light localization with minimal loss. In the pursuit of potential biocompatibility and to reduce cytotoxicity, indium phosphide colloid quantum dots are opted to serve as the emissive carriers within the system. An ultra‐narrow linewidth light emission of 0.039 nm is observed, corresponding to a quality factor reaching 16668, along with a tunable range of 1.21 nm and a temperature sensitivity of 33.52 pm K−1. The invention's compact size and tunable character make it an ideal candidate for a variety of potential applications, such as eco‐friendly sensors with minimal ecological impact, optical modulators with precise control over light, and adaptable photonic devices that can be integrated with a diverse array of materials and configurations.

Real-time monitoring of voltage-responsive biomolecular binding onto electro-switchable surfaces.

Voltage-responsive biosensors capable of monitoring real-time adsorption behavior of biological analytes onto electroactive surfaces offer attractive strategies for disease detection, separations, and other adsorption-dependent analytical techniques. Adsorption of biological analytes onto electrically switchable surfaces can be modelled using neutravidin and biotin. Here, we report self-assembled monolayers formed from voltage-switchable biotinylated molecules on gold surfaces with tunable sensitivity to neutravidin in response to applied voltages. By using electrochemical quartz crystal microbalance (EQCM), we demonstrated real-time switchable behavior of these bio-surfaces and investigate the range of sensitivity by varying the potential of the same surfaces from -400 mV to open circuit potential (+155 mV) to +300 mV. We compared the tunability of the mixed surfaces to bare Au surfaces, voltage inert surfaces, and switchable biotinylated surfaces. Our results indicate that quartz crystal microbalance allows real-time changes in analyte binding behavior, which enabled observing the evolution of neutravidin sensitivity as the applied voltage was shifted. EQCM could in principle be used in kinetic studies or to optimize voltage-switchable surfaces in adsorption-based diagnostics.

Tunable temperature-responsive photonic ionogels with dual signals output

Photonic ionogels with dual electrical and optical output have been intensively studied. However, tunable temperature-responsive photonic ionogel assembled by thermosensitive nanogels has not been studied yet. Herein, an innovative approach to fabricate photonic ionogels has been developed for smart wearable devices with tunable temperature sensitivity and structural color. Firstly, poly(isopropylacrylamide-r-phenylmaleanilic acid) P(NIPAm-r-NPMA) nanogels self-assemble into photonic crystals in 2-hydroxyethyl acrylate (HEA), water, and the ionic liquid of 1-ethyl-3-methylimidazolium trifluoromethanesulfonate. And then robust photonic ionogels are developed through a polymerization of 2-hydroxyethyl acrylate crosslinked by poly(ethylene glycol) diacrylate (PEGDA). The incorporation of the ionic liquid, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate, enhances the mechanical strength of photonic ionogels and tunes the temperature-sensitivity of the ionogels, making them adaptable to various environmental conditions. The findings demonstrate that these ionogels can serve dual functions in smart wearable devices, combining electrical and optical signal outputs due to the conductivity of the ionic liquid and structural color from the nanogel assembly. The resultant photonic ionogels exhibit exceptional substrate adhesion, mechanical stability, and fast resilience. More significantly, the nanogels within these ionogels serve as the building blocks of photonic crystals (PCs) endow with angle-independent coloration and enhance stretchability beyond 200 %, while the stretchability of the ionogles without the nanogels is only about 100 %. Our photonic ionogels with tunable temperature-sensitivity and dual outputs will open an avenue to the development of the innovative smart wearable devices.

Electronic Structure, Aromaticity, and Magnetism of Minimum-Sized Regular Dodecahedral Endohedral Metallofullerenes Encapsulating Rare Earth Atoms.

A series of minimally sized regular dodecahedron-embedded metallofullerene REC20 clusters (RE = Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, and Gd) as basic units of nanoassembled materials with tunable magnetism and UV sensitivity have been explored using density functional theory (DFT). The contribution of the 4f orbital of the rare earth atom at the center of the C20 cage to the frontier molecular orbital of REC20 gives the REC20 cluster additional stability. The AdNDP orbitals of the four REC20 superatoms that conform to the spherical jellium model indicate that through natural population analysis and spin density diagrams, we observe a monotonic increase in the magnetic moment from Ce to Gd. This is attributed to the increased number of unpaired electrons in the 4f orbitals of lanthanide rare earth atoms. The UV-visible spectrum of REC20 clusters shows strong absorption in the mid-UV and near-UV bands. REC20 clusters encapsulating lanthanide rare earth atoms stand out for their tunable magnetism, UV sensitivity, and stability, making them potential new self-assembly materials.

START: A Versatile Platform for Bacterial Ligand Sensing with Programmable Performances.

Recognition of signaling molecules for coordinated regulation of target genes is a fundamental process for biological systems. Cells often rely on transcription factors to accomplish these intricate tasks, yet the subtle conformational changes of protein structures, coupled with the complexity of intertwined protein interaction networks, pose challenges for repurposing these for bioengineering applications. This study introduces a novel platform for ligand-responsive gene regulation, termed START (Synthetic Trans-Acting Riboswitch with Triggering RNA). Inspired by the bacterial ligand sensing system, riboswitch, and the synthetic gene regulator, toehold switch, the START platform enables the implementation of synthetic biosensors for various ligands. Rational sequence design with targeted domain optimization yields high-performance STARTs with a dynamic range up to 67.29-fold and a tunable ligand sensitivity, providing a simple and intuitive strategy for sensor engineering. The START platform also exhibits modularity and composability to allow flexible genetic circuit construction, enabling seamless implementation of OR, AND, and NOT Boolean logic gates for multiple ligand inputs. The START design principle is capable of broadening the suite of synthetic biosensors for diverse chemical and protein ligands, providing a novel riboregulator chassis for synthetic biology and bioengineering applications.

A stretchable and self-powered strain sensor with elastomeric electret

Stretchable deformation sensors play an important role in the perception and autonomy of soft robots. While various sensors have been reported, the mechanical sensor with self-powered capability and stretchability to suit extreme environment is urgently required. In this study, a stretchable, self-powered, sensitivity adjustable, and long-term stability strain sensor based on the stretchable electret is researched for deformation monitoring. This stretchable and self-powered sensor is composed of the dielectric elastomer with designed elastic modulus gradient and the stretchable electret with elastomeric and Nano-particles. The electro-mechanical capability of this designed sensor is researched and optimized by multi-objective optimization approach. The sensor exhibits self-powered capability, stretchability (tensile strain from 0% to 20%), tunable sensitivity (optimized from 5.7 to 5.9 pC mm−1), and stability, where electromechanical performance remains stable after 8000 stretching cycles. The feasibility of its autonomous sensing which promotes a wide range of potential application in soft robotics is demonstrated. This elastic modulus gradient-induced and net charge design significantly broadened the potential applications with large deformation and low-attached stiffness.

A chemogenetic approach for dopamine imaging with tunable sensitivity

Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. Here we show that a human-selective dopamine receptor positive allosteric modulator (PAM) can be used to boost sensor affinity on-demand. The PAM enhances DA detection sensitivity across experimental preparations (in vitro, ex vivo and in vivo) via one-photon or two-photon imaging. In vivo photometry-based detection of optogenetically-evoked DA release revealed that DETQ administration produces a stable 31 minutes window of potentiation without effects on animal behavior. The use of the PAM revealed region-specific and metabolic state-dependent differences in tonic DA levels and enhanced single-trial detection of behavior-evoked phasic DA release in cortex and striatum. Our chemogenetic strategy can potently and flexibly tune DA imaging sensitivity and reveal multi-modal (tonic/phasic) DA signaling across preparations and imaging approaches.

Rare Earth Material for Hydrogen Gas Sensing: PtGd Alloy Thin Films as a Promising Frontier.

At the focus of our investigation lies the precision fabrication of ultrathin platinum-gadolinium (PtGd) alloy films, with the aim to use these films for resistive hydrogen gas sensing. The imperative for sensitive and selective sensors to harness hydrogen's potential as an alternative energy source drives our work. Applying rare earth materials, we enhance the capabilities of hydrogen gas sensing applications. Our study pioneers PtGd alloy thin films for hydrogen gas sensing, addressing a gap in existing literature. Here, we demonstrate the functional characteristics of 2 nm thick PtxGd100'x (x = 25, 50 and 75) alloy films, analyzing their hydrogen gas sensing properties, comprehensively examining the interplay between alloy composition, temperature fluctuation and hydrogen concentration. The effect of composition and structural properties on the sensing response were assessed using EDX and XPS. The films are tested at a temperature range between 25 °C and 150 °C with hydrogen gas concentrations ranging from 10 ppm to 5%. Hydrogen gas sensing mechanisms in PtGd alloy ultrathin films are explained by surface scattering. The unique combination of Pt and Gd offers promising characteristics for gas sensing applications, including high reactivity with hydrogen gas and tunable sensitivity based on the alloy composition.

Stretchable MXene/Carbon Nanotube Bilayer Strain Sensors with Tunable Sensitivity and Working Ranges.

Stretchable strain sensors have gained increasing popularity as wearable devices to convert mechanical deformation of the human body into electrical signals. Two-dimensional transition metal carbides (Ti3C2Tx MXene) are promising candidates to achieve excellent sensitivity. However, MXene films have been limited in operating strain ranges due to rapid crack propagation during stretching. In this regard, this study reports MXene/carbon nanotube bilayer films with tunable sensitivity and working ranges. The device is fabricated using a scalable process involving spray deposition of well-dispersed nanomaterial inks. The bilayer sensor's high sensitivity is attributed to the cracks that form in the MXene film, while the compliant carbon nanotube layer extends the working range by maintaining conductive pathways. Moreover, the response of the sensor is easily controlled by tuning the MXene loading, achieving a gauge factor of 9039 within 15% strain at 1.92 mg/cm2 and a gauge factor of 1443 within 108% strain at 0.55 mg/cm2. These tailored properties can precisely match the operation requirements during the wearable application, providing accurate monitoring of various body movements and physiological activities. Additionally, a smart glove with multiple integrated strain sensors is demonstrated as a human-machine interface for the real-time recognition of hand gestures based on a machine-learning algorithm. The design strategy presented here provides a convenient avenue to modulate strain sensors for targeted applications.

Piezoresistive sensitivity enhancement below threshold voltage in sub-5 nm node using junctionless multi-nanosheet FETs

In this paper, the piezoresistive sensitivity is enhanced by applying uniform mechanical stress (MS) on the multi-nanosheet (NS) channels of sub-5 nm junctionless field-effect transistors. The piezoresistivity of the sensing device is boosted by narrowing channel conductivity using low gate biasing and reducing physical channel width, resulting in the maximum (∼6 times higher) sensitivity observed in the subthreshold regime compared to the ON-state condition. In addition, the sensitivity is extensively increased by ∼30.3% near the threshold voltage with horizontally multi-NS stacking due to the uniform MS distribution on the multi-NS channels, which can sense slight deflection of pressure on the circular diaphragm. These results show that the tunable sensitivity of junctionless multi-channel devices is superior to the inversion mode, a consequence of the less scattering effect, better thermal stability, and low electronic noise.

Conductive polymer composites-enable self-sensing twisted string actuators

Twisted string actuators (TSAs) are innovative linear soft actuators that can mimic natural muscle contraction. However, obtaining feedback on their stroke requires cumbersome external sensors that compromise their compliance. We addressed this by developing self-sensing strings using conductive polymer composites (CPCs). The CPC strings exhibit electrical resistance changes in response to strain, enabling stroke sensing by the strings themselves. We fabricated CPCs strings with varying concentrations of multi-walled carbon nanotubes (MWCNTs). Characterization revealed excellent conductivity, tensile strength exceeding 30 N, tunable strain sensitivity via MWCNTs concentration variation, as well as stable and repeatable strain-dependent resistance changes. Optimization via a high-strength core fiber enabled the CPCs strings to withstand over 6[Formula: see text]kg loading with enhanced stroke and minimal resistance variation. We achieved at least a 97.8% linear correlation between resistance change rate and contraction rate in twisting experiments. This research provides a self-contained stroke sensor compatible with high-load soft TSAs, overcoming limitations of external sensors. The simple yet effective sensing mechanism could spur adoption of TSA in robotics.

High-Q Multiband Narrowband Absorbers Based on Two-Dimensional Graphene Metamaterials

In this paper, an absorber with multi-band, tunable, high Q, and high sensitivity, based on terahertz periodic two-dimensional patterned graphene surface plasmon resonance (SPR), is proposed. The absorber consists of a bottom metal film separated by a periodically patterned graphene metamaterial structure and a SiO2 dielectric layer, where the patterned graphene layer is etched by “+” and “L” shapes and circles. It has simple structural features that can greatly simplify the fabrication process. We have analyzed the optical properties of a graphene surface plasmon perfect metamaterial absorber based on graphene in the terahertz region using the finite-difference method in time domain (FDTD). The results show that the absorber device exhibits three perfect absorption peaks in the terahertz bands of f1 = 1.55 THz, f2 = 4.19 THz, and f3 = 6.92 THz, with absorption rates as high as 98.70%, 99.63%, and 99.42%, respectively. By discussing the effects of parameters such as the geometrical dimensions of patterned graphene metamaterial structure “+” width W1, “L” width W2, circular width R, and the thickness of the dielectric layer on the absorption performance of absorber, as well as investigating the chemical potential and relaxation time of patterned-layer graphene material, it was found that the amplitude of the absorption peaks and the frequency of resonance of absorber devices can be dynamically adjusted. Finally, we simulated the spectra as the surrounding refractive index n varied to better evaluate the sensing performance of the structure, yielding structural sensitivities up to 382 GHz/RIU. Based on this study, we find that the results of our research will open new doors for the use of multi-band, tunable, polarization-independent metamaterial absorbers that are insensitive to large-angle oblique incidence.

Fiber Bragg grating sensing system for temperature measurements based on optically injected DFB-LD with an OEO loop

A novel fiber Bragg grating (FBG) sensing system, based on an optically injected distributed feedback laser diode (DFB-LD) with an optoelectronic oscillating (OEO) loop, is proposed and experimentally demonstrated for temperature measurements with high and tunable sensitivity. The FBG sensor device works as an edge filter to adjust the optical power of the injected beam in response to temperature variations. The optically injected DFB-LD works at Period-one (P1) oscillating state, and the central wavelength of the oscillating mode of the DFB-LD can be tuned by the variable power of the injected beam. Furthermore, an OEO loop is implemented to improve the signal quality of the generated P1 microwave signal. Hence, the sensing parameter of temperature is converted to the frequency variation of the generated P1 microwave signal in the proposed sensing system. In the proof-of-concept experiment, a series of P1 microwave signals are generated while different temperatures are applied to the FBG sensor. The sensitivity of the proposed FBG sensing system for temperature measurements can be tuned from 0.44322 GHz/°C to 1.25952 GHz/°C. The stability and repeatability experiments are also performed, demonstrating the high measurement accuracy (0.0629°C) and low error of the system. The proposed FBG-based sensing and interrogation system exhibits high sensitivity, large tunability, good linearity, and flexible sensing generality.

Concurrent geometrico-topological tuning of nanoengineered auxetic lattices fabricated by material extrusion for enhancing multifunctionality: Multiscale experiments, finite element modeling and data-driven prediction

This study demonstrates the multifunctional performance of innovative 2D auxetic lattices through a combination of multiscale experiments, finite element modeling and data-driven prediction. A geometric modeling approach utilizing Voronoi partitioning and a unique branch-stem-branch (BSB) structure, patterned according to 2D wallpaper symmetries, enables precise concurrent geometric and topological tuning of lattices across a continuous parameter space. Selected architectures are physically realized via material extrusion of polylactic acid (PLA) infused with carbon black (CB). Experimental characterizations, supported by Finite Element modeling, reveal the significant influence of BSB structure's design parameters on mechanical and piezoresistive performance under tensile loading, with a remarkable Poisson’s ratio of -0.74, accompanied by a 15-fold increase in elastic stiffness and a 34-fold increase in strain sensitivity. Additionally, architecturally, and topologically tailored lattice structures exhibit tunable damage sensitivity, reflecting the rate of conductive network destruction within the lattice. This offers insights into the rapidity of cell wall failure, with a steeper slope of the piezoresistance curve in the inelastic regime indicating a faster breakdown and quicker onset of mechanical failure. Integration of Gaussian Process Regression enables accurate exploration of the design space beyond realized structures, highlighting the potential of these intelligent lattice structures for applications such as sensors and in situ health monitoring, marking a significant advancement in multifunctional materials.