Open-path spectroscopy is known for its ability to provide real-time measurements of dozens of compounds over sampling paths of up to 1000 meters in length. Advances in open-path monitoring technology and data processing techniques, coupled with new regulatory requirements, have greatly increased the acceptance and widespread application of spectroscopy-based open-path measurements. Large industrial facilities adjacent to residential communities are a particular application of interest, because traditional fixed-point analyzers lack the spatial coverage of the open-path instruments. This work discusses technical and practical considerations for the installation and operation of more than 120 open-path analyzers that are currently providing continuous data at several oil refineries in California. Open-path analyzers include ultraviolet differential optical absorbance spectroscopy (UV-DOAS), Fourier transform infrared (FT-IR), and tunable diode laser (TDL) technologies. We will discuss lessons learned from these projects, including fundamental approaches to compound identification, target species detectability, interferences, and data management.