Trust Research Research Articles

Towards the measurement of consumer trust in media brands—scale development and validation

ABSTRACT Media brands in today’s digitized economy are facing growing competition and the increasing need for valid parameters to measure success and the perception of their brand. Trust in media brands is one of the most important factors in that regard, influencing the decision for and against certain media brands and driving factors, such as brand equity and usage intention. While research on trust in corporate, product and service brands is abundant, trust research specifically focusing on media brands has been widely neglected. Due to the strong possible impact of singular events particularly on trust in media brands and the connected high variance in consumer trust, a valid tool to track consumer perceptions over time thus would add a worthwhile contribution to media management. Due to significant differences between brands and media brands based on divergent business models, business partners and sources of revenue, currently available brand trust scales, however, cannot simply be applied in the media sector. In our study, we are conducting quantitative, multinational research to establish a valid and reliable media brand trust scale. We aim for the empirically based development of the focal construct building on the framework of media brand trust. The framework results from 11 components derived from previous studies. With this development, we are providing actors of the media economy with a scale to measure consumers’ trust in the media brand and generating an understanding of the specific elements required to improve media brands’ business operations.

Artificial intelligence research in radiation oncology: a practical guide for the clinician on concepts and methods.

The use of artificial intelligence (AI) holds great promise for radiation oncology, with many applications being reported in the literature, including some of which are already in clinical use. These are mainly in areas where AI provides benefits in efficiency (such as automatic segmentation and treatment planning). Prediction models that directly impact patient decision-making are far less mature in terms of their application in clinical practice. Part of the limited clinical uptake of these models may be explained by the need for broader knowledge, among practising clinicians within the medical community, about the processes of AI development. This lack of understanding could lead to low commitment to AI research, widespread scepticism, and low levels of trust. This attitude towards AI may be further negatively impacted by the perception that deep learning is a "black box" with inherently low transparency. Thus, there is an unmet need to train current and future clinicians in the development and application of AI in medicine. Improving clinicians' AI-related knowledge and skills is necessary to enhance multidisciplinary collaboration between data scientists and physicians, that is, involving a clinician in the loop during AI development. Increased knowledge may also positively affect the acceptance and trust of AI. This paper describes the necessary steps involved in AI research and development, and thus identifies the possibilities, limitations, challenges, and opportunities, as seen from the perspective of a practising radiation oncologist. It offers the clinician with limited knowledge and experience in AI valuable tools to evaluate research papers related to an AI model application.

Cooking Time, Seed Darkening, and Iron and Zinc Concentrations of Selected Andean Genotypes of Common Bean

ABSTRACTCooking time (CT), post‐harvest darkening (PHD), and micronutrient content influence consumer preference of common bean (Phaseolus vulgaris L.) varieties. The objective of this study was to evaluate Andean genotypes for CT, PHD, and seed iron and zinc concentration. A total of 52 genotypes belonging to three market classes, namely, purple‐speckled (Kabulangeti), yellows, and cranberry (sugar beans), were grown at the Golden Valley Agricultural Research Trust (GART) Farm and the Mpika Research Farm in Zambia and assessed for CT, PHD, and seed iron and zinc concentration. The fastest cooking genotype among all 52 genotypes was a yellow genotype, Y1612‐5. Yellow genotypes generally cooked faster than the Kabulangeti and sugar types. Among the elite lines with Kabulangeti seed types, which is a dominant market class in Zambia, the elite line K175 had faster CT and higher iron and zinc concentration than the Kabulangeti landrace race currently available on the Zambian market. Kabulangeti and sugar genotypes showed regular darkening, whereas yellows did not darken. The yellow genotype Y1612‐3 was particularly outstanding because of its unique combination of high concentrations of both iron and zinc. Therefore, it can be used to introgress these two essential minerals into variable genetic backgrounds. The significant variability and high to moderate heritability for CT (0.85) and iron (0.81) and zinc (0.58) concentration observed in the current study suggest that it is possible to make progress in breeding for faster cooking varieties that are rich in iron and zinc.

Building Trust to Study Trust: Paving the Way for Applied Trust Research in Social and Resocializing Institutions

Trust plays a pivotal role when aiding individuals in vulnerable positions. However, understanding the practical dynamics of trust remains limited. Empirical research on trust, particularly in collaborative and applied settings, is scarce. Trust in communications training is often treated as a nebulous concept, complicating its operationalization. This article delineates the initial stages of an applied research project on trust building in encounters between practitioners and citizens in vulnerable positions, outlines our project’s design, and details our experiences with cultivating trust with our participants. Employing an applied conversation analytic approach, we use video- and audio-ethnography to capture everyday interactions between employees and residents in social and re-socializing institutions. Combining a trust-building approach to get access to the field with rigorous analysis, we eventually aim to identify indicators of trust and distrust. Our distinctive approach, combining design, execution, and collaboration with inspiration from participant-oriented research, ensures relevance, accessibility, quality, and feasibility of our research will contribute to the conceptualization of trust as a social interactional phenomenon. It fosters co-ownership with practitioners, enhancing the impact of our findings, and allows us to rewrite the teaching material for future generations of social workers.

Long-term waning of vaccine-induced immunity to measles in England: a mathematical modelling study

Among people infected with measles in England between 2010 and 2019, the proportion of cases who had previously received two doses of vaccine has increased, especially among young adults. Possible explanations include rare infections in vaccinated individuals who did not gain immunity upon vaccination, made more common because fewer individuals in the population were born in the endemic era, before vaccination was introduced, and exposed as part of endemic transmission, or the waning of vaccine-induced immunity, which would present new challenges for measles control in near-elimination settings. We aimed to evaluate whether measles dynamics observed in England between 2010 and 2019 were in line with a waning of vaccine-induced immunity. We used a compartmental mathematical model stratified by age group, region, and vaccine status, fitted to individual-level case data reported in England from 2010 to 2019 and collected by the UK Health Security Agency. The deterministic model was fitted using Monte Carlo Markov Chains under three scenarios: without the waning of vaccine-induced immunity, with waning depending on time since vaccination, and with waning depending on time since vaccination, starting in 2000. We generated stochastic simulations from the fitted parameter sets to evaluate which scenarios could replicate the transmission dynamics observed in vaccinated cases in England. The scenario without waning overestimated the number of one-dose recipients among measles cases, and underestimated the number of two-dose recipients among cases older than 15 years (median 75 cases [95% simulation interval (SI) 44-124] in simulations without waning, 196 [95% SI 122-315] in simulations when waning was included, 188 [95% SI 118-301] in simulations when waning started in 2000, and 202 observed cases). The number of onward transmissions from vaccinated cases was 83% (95% credible interval 72-91%) of the number of transmissions from unvaccinated cases. The estimated waning rate was slow (0·039% per year of age; 95% credible interval 0·034-0·044% per year in the best-fitting scenario with waning starting in 2000), but sufficient to increase measles burden. Measles case dynamics in England are consistent with scenarios assuming the waning of vaccine-induced immunity. Since measles is highly infectious, slow waning leads to a heightened burden in outbreaks, increasing the number of measles cases in people who are both vaccinated and unvaccinated. Our findings show that although the vaccine remains highly protective against measles infections for decades and most transmission is connected to people who are unvaccinated, breakthrough infections are increasingly frequent for individuals aged 15 years and older who have been vaccinated twice. National Institute for Health and Care Research and Wellcome Trust.

A revision of the genus Neoliparina Schultze, 1934, with descriptions of three new species (Lepidoptera, Erebidae, Lymantriinae)

The tussock moth genus Neoliparina Schultze, 1934, has been regarded as monotypic since its erection 90 years ago, however, investigation into material housed in the Lymantriinae collections of the African Natural History Research Trust revealed a further three species belonging to this genus, which are described in this paper: Neoliparina smithi sp. n., N. schultzei sp. n. and N. nyonie sp. n. Schultze’s (1934) original descriptions of Neoliparina and its type species N. paradoxa Schultze, 1934 were based upon a single female specimen, and as such a detailed morphological examination of both sexes is provided in this paper. All four species show remarkably strong divergence in genitalia morphology and external habitus perhaps unusual for the Lymantriinae. The paper is illustrated with 12 diagnostic figures of adults and genitalia of both sexes of each species.

Severe hypocalcaemia and hypophosphatemia following Denosumab administration in a multi-comorbidity patient

The case is presented of an elderly patient (DCP) with extensive medical history, including osteoporosis, who developed hypocalcaemia and hypophosphataemia whilst treated with denosumab, while prescribed concomitant calcium and vitamin D therapies. The management of this complex case involved a multidisciplinary team (MDT) approach, incorporating the patient’s wishes. It included discontinuation of denosumab and intravenous (IV) and oral mineral supplementation that yielded gradual amelioration of calcium and phosphate levels. This case demonstrates the importance of vigilant monitoring and appropriate management in patients receiving denosumab, particularly those with multiple comorbidities. It carries important considerations for using denosumab for osteoporosis treatment in patients with complex medical backgrounds. Ethical clearance waiver was granted by the Trust Research Ethics Committee on 18/01/2024.

Translation and Validation of the Arabic Version of the Cerebral Palsy-Quality of Life Child Self-Reported Questionnaire Among Children in the Saudi Arabian Population.

This study aimed to assess the psychometric properties of the Cerebral Palsy-Quality of Life Child Self-Reported (CP-QoL Child Self-Report) questionnaire after it was translated and culturally adapted into Arabic. This is a cross-sectional study that was conducted during the period from February 2021 to June 2023 in Sultan Bin Abdulaziz Humanitarian City (SBAHC) and the Children with Disability Association in Riyadh, Saudi Arabia, on children with cerebral palsy (CP) between the ages of nine to 12 years. After translation and cross-cultural adaptation, the questionnaire was administered to 65 children. The reliability and internal consistency of the tool were assessed using the intraclass correlation coefficient (ICC) and Cronbach's alpha. The validity was analyzed through the association between the CP-QoL Child Self-Report questionnaire and the Arabic version of the Pediatric Quality of Life Inventory (PedsQL) 3.0-CP module (Mapi Research Trust, Lyon, France) using Pearson's correlation coefficient. The overall internal consistency was 0.870, where it ranged from 0.616 for the pain and impact of disability domain to 0.748 for the social well-being and acceptance domain. The interobserver (test-retest) reliability ranged from 0.540 to 0.779. There was a weak correlation between the domains of the CP-QoL Child Self-Report questionnaire and different domains of PedsQL-CP module. The overall quality of life (QoL) score of the children with CP who participated in the current study was 57.86±4.97. The result of the current study suggests that the English version of the CP-QoL Child Self-Report questionnaire was effectively translated into Arabic and had good psychometric properties in evaluating the QoL of Saudi children with CP aged between nine and 12 years.

Associations between rural/urban status, duration of untreated psychosis and mode of onset of psychosis: a mental health electronic clinical records analysis in the East of England, UK.

The influence of rurality on the duration of untreated psychosis (DUP) in first-episode psychosis (FEP) is poorly understood. We investigated factors associated with FEP in rural/urban settings and whether there are rural/urban differences in DUP and the mode (speed) of onset of psychosis. We used the Cambridgeshire and Peterborough NHS Foundation Trust Research Database (CPFTRD) to identify all persons presenting to an early intervention for psychosis service with FEP between 2013 and 2015. We performed descriptive statistics and multivariable linear and multinomial regression to assess the relationships between the study outcomes and the independent variables. One hundred and fifty-five FEP patients were identified, with a mean age of 23.4 (SD, 5.3) years. The median DUP was 129.0 (IQR: 27.5-524.0) days. In rural areas, FEP patients were more likely to be employed and live with family than those in urban areas. A longer DUP was observed among patients with an insidious onset of psychosis compared with an acute onset (619.5 (IQR: 333.5-945.0)) vs. (17.0 (IQR: 8.0-30.5)) days respectively, p < 0.0001. We found evidence that the mode of onset of psychosis differed by employment status and living circumstances. There was insufficient evidence of rural/urban differences in DUP and mode of onset of psychosis. Our results suggest that the mode of onset of psychosis is an important indicator of treatment delay and could provide vital information for service planning and delivery. Sociodemographic variations in FEP exist in rural populations, and our findings are similar to those observed in urban settings.

Utilizing Ethnographical Approaches to Study the Abstract, Intimate, and Dynamic Topic of Trust

There is an increased need to acquire a more holistic and situated understanding of how and why experiences unfold during real-life situations, especially during research focused on identifying nuanced and dynamic phenomena such as trust. Trust researchers need to revisit and expand their methodological toolkit with immersive qualitative methods for the researching of lived experiences of abstract, intimate, and dynamic experiences. In this article, we discuss two ethnographical approaches to qualitative trust research—autoethnography and at-home ethnography. We illustrate this discussion through two case vignettes from our studies of nuanced and dynamic organizational relationships in which we as researchers were also positioned as a part of the data. We apply philosophical principles connected to reflexivity and provide examples of the researcher as a subject during the study of unfolding vulnerabilities of the field and the researcher.

Lessons from the pandemic: An innovative scheme to support research in the North West Coast

In 2021, a Clinical Research Fellow (CRF) scheme was created to serve the North West Coast (NWC) region in line with the key health priorities set out by the Clinical Research Network. Five doctors in pre-specialist training were placed in NHS trust research departments across the NWC. The scheme aimed to provide early career research experience while also enhancing the provision of research across the region. The CRFs were involved in writing clinical trial grant applications and study protocols, with the scheme providing additional experience in leadership roles and time management. In addition, the CRF scheme has had a positive impact in adopted NHS trusts, which have seen their overall research capacity and capability improve, through increased flexibility and medical oversight. Research departments have benefited from increased financial income and improved national reputations. Overall, this real-world experience provided a vital ‘foot in the door’, which is essential for research-interested medics to advance in a future academic career. In the wider NWC region, the CRF scheme successfully delivered achievable and financially sustainable research. Innovative programmes such as this one should be seen as a viable option for research provision through the NHS, in the UK.

Trust in interaction studies

Trust is argued to be essential in fostering cooperative communication, whereas a lack of trust is seen as detrimental to these aims. Over the years, there has been a slow but steady stream of research that has aimed to shed light on how trust is accomplished or broken down through discursive-interactional practices. In this mini review, we examine existing studies that take trust as a topic of investigation using micro-analytic, interactional methods, in order to provide readers with an up-to-date overview on new developments in this important field of research. From this review, we conclude that there exist two different, yet complementary, views on trust: Trust as an interactional principle and trust as a discursively accomplished phenomenon. We not only summarize important discursive work that provides a unique lens on how trust may be established and maintained through verbal and non-verbal resources, but also suggest some of the challenges interactional trust research still faces and some important areas for further investigation in which trust is a major concern.

“YOU THINK YOU'VE GOT THEM ON BOARD AND THEN THEY'RE BACK”: PRIMARY CARE CLINICIANS’ EXPERIENCES OF OFFERING SELF-MANAGEMENT ADVICE TO PEOPLE WITH BACK PAIN

Purpose and background of the studySelf-management and behaviour change is at the core of back pain management. Despite the high-rate of recurrence and healthcare utilisation, clinical guidelines do not include guidance for clinicians on return consultations. This project aimed to identify primary care clinicians’ reported practices and experiences of delivering self-management advice for people returning with persistent low back pain (LBP), to inform future delivery of self-management care.Methods and ResultsIn this qualitative study involving 27 primary care clinicians, four focus groups and two semi-structure interviews were conducted online. GPs (n=5) and physiotherapists working in primary care roles (First contact practitioners n=7, community and interface roles n=7, and mixed roles n=8) in England and Scotland shared their experience of delivering self-management advice to people returning with persistent LBP. Video recordings were transcribed verbatim and analysed with reflexive thematic analysis.Clinicians unanimously shared their frustrations identifying the challenges involved in supporting people who return with LBP. Helpful strategies to support self-management in return consultations were identified by clinicians in addition to service and system-level changes vital to optimise care. Patient-factors affecting delivery of care, lack of defined responsibility and challenges in meeting patients’ expectations illustrated the tensions that exist in return consultations.ConclusionThis novel study provides insight into the experiences and practices of the frontline primary care workforce seeing patients return with persistent or recurrent LBP. It identifies the tensions that exist between services, professional roles and between clinicians and patients regarding self-management. Important practice implications have been identified to improve information-sharing, agenda-setting, and exploring expectations.No conflicts of interest Source of fundingLisa Osborn-Jenkins is funded by University Hospital Southampton NHS Foundation Trust (UHS) Research &amp; Development PhD Fellowship [GRT0723]

WHOM DO WE TRUST? ON HOW WE ASSESS OTHERS’ TRUSTWORTHINESS

The aim of this paper is to integrate competing notions of trustworthiness in the literature on trust under a common framework. I defend a notion of trustworthiness around three criteria: competence, predictability, and responsiveness. These are both necessary and sufficient conditions for trustworthiness assessments. Competence means having the required abilities to fulfill one’s trust in a certain matter, but also the capacity to understand, assess, and choose the best way to apply those abilities in that matter. Predictability means both reliability and having the relevant reasons to fulfill one’s trust in that respective matter. Responsiveness captures the trustee’s intentionality about or directed at the trustor, her willingness to fulfill her trust. The three criteria are not fixed characteristics of the trustee; assessments of each will reflect aspects that are relevant under specific trust situations. The criteria seek to establish a common ground for trust research to reconcile different perspectives, while recognizing that trust is a highly contextual and relational notion.

Integrating focal vulnerability into trust research

ABSTRACT Trust – most often defined as the trustor’s willingness to accept vulnerability – matters across almost every facet of modern life. Significant bodies of research have been devoted to understanding the nature and dynamics of the construct, but much less work has directly considered the vulnerability at the core of its definition. The current article addresses this gap, elucidating the concept of focal vulnerability as the portion of the trustor’s individualised, total potential for experiencing harm that is perceived, relational, and contemporaneous with their assessment of trust. We then position this concept as the vulnerability that a trustor is, by definition, willing to accept. Following work in other literatures, we consider the dynamics of focal vulnerability by exploring the systematic ways in which it is likely to vary. We then argue that this variability can be meaningfully captured by assessing the extent to which the trustor experiences felt vulnerability, an aversive recognition of their potential for experiencing harm. We conclude by exploring the implications of this argument and outline several untested assumptions that are ripe for future research.

A study on Ethics, Integrity, and Trust in Research: An Interdisciplinary Perspective

This research article explores the interconnectedness of research ethics, integrity, and trust from several vantage points. This research seeks to expand our knowledge of the complex nature of ethical issues and t heir impact on research integrity and trust by incorporating views from a wide range of disciplines. Autonomy, beneficence, fairness, and non-maleficence are some of the cornerstones of research ethics that are discussed in this article. Informed permission, privacy, conflicts of interest, and the use of human and animal subjects are only few of the ethical issues that are discussed, along with their implications throughout the study process. Research ethics committees, institutional frameworks, and ethical norms are all considered in terms of their respective roles in encouraging ethical behaviour and upholding research integrity. The article also explores the effects of research misconduct and other ethical lapses on public faith in the scientific community and the reliability of research findings. It stresses the significance of research practises that are both open and responsible for building and maintaining credibility. This research article concludes by emphasising the necessity of ethics, integrity, and trust in research, and pointing out the importance of multidisciplinary cooperation, strong supervision systems, and education in promoting and upholding these values.

Trusting the trust machine: How does blockchain-enabled governance configuration enhance financing credibility?

This study highlights the role of blockchain technology in addressing the trust crisis in supply chain operations and financial activities. While previous research has acknowledged blockchain as a response to trust issues, limited studies have explored its specific contributions and its impact on accelerating cash flow in supply chains. Drawing on governance theory, this study investigates the relationship between blockchain technology and supply chain finance (SCF) through multiple case studies. The central argument is that blockchain technology alone does not automatically generate trust. Instead, trust is established through the configuration of various governance mechanisms. We propose that trust in blockchain applications is derived from two main factors: the requirement of codifiability and verifiability. Through a cross-case analysis, we found that in situations where both the requirement of codifiability and verifiability are high, blockchain governance tends to dominate. When only one factor is high, a configuration of blockchain governance and relational governance emerges. When both factors are low, contractual governance proves to be efficient. This study underscores the need for a nuanced understanding of trust dynamics in blockchain applications and highlights the importance of considering contextual factors in trust research related to blockchain technology.

Combating Fraudulent Participation in Urban American Indian and Alaska Native Virtual Health Research: Protocol for Increasing Data Integrity in Online Research (PRIOR).

While the advantages of using the internet and social media for research recruitment are well documented, the evolving online environment also enhances motivations for misrepresentation to receive incentives or to "troll" research studies. Such fraudulent assaults can compromise data integrity, with substantial losses in project time; money; and especially for vulnerable populations, research trust. With the rapid advent of new technology and ever-evolving social media platforms, it has become easier for misrepresentation to occur within online data collection. This perpetuation can occur by bots or individuals with malintent, but careful planning can help aid in filtering out fraudulent data. Using an example with urban American Indian and Alaska Native young women, this paper aims to describe PRIOR (Protocol for Increasing Data Integrity in Online Research), which is a 2-step integration protocol for combating fraudulent participation in online survey research. From February 2019 to August 2020, we recruited participants for formative research preparatory to an online randomized control trial of a preconceptual health program. First, we described our initial protocol for preventing fraudulent participation, which proved to be unsuccessful. Then, we described modifications we made in May 2020 to improve the protocol performance and the creation of PRIOR. Changes included transferring data collection platforms, collecting embedded geospatial variables, enabling timing features within the screening survey, creating URL links for each method or platform of data collection, and manually confirming potentially eligible participants' identifying information. Before the implementation of PRIOR, the project experienced substantial fraudulent attempts at study enrollment, with less than 1% (n=6) of 1300 screened participants being identified as truly eligible. With the modified protocol, of the 461 individuals who completed a screening survey, 381 did not meet the eligibility criteria assessed on the survey. Of the 80 that did, 25 (31%) were identified as ineligible via PRIOR. A total of 55 (69%) were identified as eligible and verified in the protocol and were enrolled in the formative study. Fraudulent surveys compromise study integrity, validity of the data, and trust among participant populations. They also deplete scarce research resources including respondent compensation and personnel time. Our approach of PRIOR to prevent online misrepresentation in data was successful. This paper reviews key elements regarding fraudulent data participation in online research and demonstrates why enhanced protocols to prevent fraudulent data collection are crucial for building trust with vulnerable populations. ClinicalTrials.gov NCT04376346; https://www.clinicaltrials.gov/study/NCT04376346. DERR1-10.2196/52281.

Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire in Persian: A Report on the Translation Process

Background: Rapid eye movement sleep behavior disorder (RBD) is a condition where there are changes in muscle tone during REM sleep, leading to abnormal movements. This disorder is typically diagnosed using video polysomnography (VPSG), which is considered the gold standard test. However, a screening questionnaire for RBD (RBDSQ) has been developed, translated, and validated in various languages, and could be used as a low-cost alternative to VPSG. In this study, we followed a standard multi-step process to translate the RBDSQ into Persian. Methods: As per the guidelines suggested by Mapi Research Trust, we followed a four-step process for translation. The process included forward translation, backward translation, cognitive interviews with fifteen patients, and proofreading. We collaborated with Mapi Research Trust in each step of the process. Also, we conducted discussion and revision sessions for each step to ensure that the final translation was accurate. Results: After reviewing the forward and backward translations, some of the items were rephrased. Patients who participated in cognitive interviews found the translation to be generally clear, but some improvements were necessary to make it more expressive. The final proofreading process involved correcting some typing and spelling errors. Conclusions: The Persian translation of RBDSQ was approved by Mapi Research Trust through a standard translation process. This translation is now compatible with the original English version and is available for a future clinical validation study.

Trends and landscape of clinical outcome assessment use to support oncology product approvals.

e23186 Background: The regulatory landscape in oncology trials has evolved with growing emphasis on patient-focused drug development. Further to tumor and survival outcomes, measuring how patients feel and function via clinical outcome assessments (COAs) provides critical information on symptoms and treatment burden and may help to inform risk/benefit evaluation for new treatments. This study aimed to examine trends in the use of COAs to support efficacy or safety in oncology product labeling. Methods: Product labeling information was obtained from PROLABELS (Mapi Research Trust), a database containing COA-related data sourced from the efficacy or safety sections of FDA Product labels and EMA SmPC where at least one COA is mentioned. Oncology product labels were screened based on therapeutic indications and study information. The clinical study details published in the label/SPC between 1990 and 2022 were used for further analysis. Results: A total of 180 EMA and FDA approved drugs and devices for oncology indications where COAs were mentioned in the product label were identified. 288 studies with COAs supported these drug approvals. These studies were in 52 different indications, with most in multiple myeloma (31), followed by non-small-cell lung cancer (24), prostate cancer (22), and breast cancer (22). Of the COAs that were used, 47% were patient-reported outcomes, 18% were clinician-reported outcomes, 30% were composites, and 5% were unspecified. The number of studies conducted with COAs supporting a product label increased over time, with 3x more studies in the past 10 years (189 from 2013-2022) compared to the previous 10 years (60 from 2003-2012). For studies listing specific COA names, 63 unique COAs were used. Excluding response criteria assessments, the most common COAs were the EORTC-QLQ-C30 (57 studies), EORTC-QLQ-LC13 (18 studies), and EQ-5D-3L (17 studies). The two indications with the largest variety of COAs used were prostate cancer (10 unique COAs) and non-small-cell lung cancer (9 unique COAs). Conclusions: In line with regulators highlighting the utility of COAs in evaluating clinical benefit, results show an increase in studies using COAs to support efficacy and safety in oncology product approvals. With COAs providing critical information on symptoms, side effect impact, and quality of life, including this information on labels may help patients and providers make more informed healthcare decisions, and for market differentiation.