Optimization of materials and structures is a crucial step in the design of man-made mechanical components for a wide field of engineering applications. It also plays a key role in mechanobiology of living systems, being involved by nature across the scales, from single-cell to tissues and organs, as a strategy to minimize metabolic cost and maximize biomechanical performances. The synergy between the continuously increasing development of high-resolution 3D printing technologies and the possibility to predict chemical and physical properties through molecular dynamics-based numerical analyses has recently contributed to boost the use of both design and topology optimization procedures. They are employed in ab initio simulations as key strategies for deciding microstructures to improve mechanical performances and, concretely, to achieve prototypes of new material components. With this in mind, we here propose to abandon the classical approach of using a single scalar objective function employed in the classical design and topology optimization strategies, to introduce multiple quantities to be minimized, identified as the differences between material yield stress and the maximum von Mises stress. After mathematically justifying the well-posedness of this unconventional choice for the case at hand, it is highlighted that the proposed strategy is based on the concept of "equalizing" a proper stress measure at any point of the body and, for this reason, it is baptized as Galilei’s optimization, in honor of the Italian scholar who somehow first wondered about the possibility of changing sizes of beams to have uniform internal forces and, in turn, minimum weight. By exploiting analytical solutions and ad hoc implementing a parametric finite element algorithm to be applied to a wide variety of solids with arbitrary complex structural geometries, including nested or hierarchically organized architectures, it is first demonstrated that the proposed optimization strategy roughly retraces principles invoked by nature to guide growth, remodeling and shaping of biomaterials. More importantly, by means of several benchmark examples, we finally show the proposed procedure might be also helpfully employed to conceive a new class of micro-structured, eventually 3D-printed materials exhibiting surprising post-elastic properties, such as high overall resilience and toughness, in particular obtaining a decrease of stress concentration and a slowing down of crack propagation as direct effects of the optimization, which de facto minimizes stress gradients wherever in the solid domain.
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