The impact of automobiles on pavement infrastructure is escalating with the expansion of economic activity and road networks. Overloading of freight trucks has emerged as a significant challenge in the realm of heavy vehicle control and management, primarily due to the adverse effects on road surfaces and traffic safety. Self-sensing pavement materials offer the prospect of autonomous monitoring of forces exerted on the pavement without relying on embedded sensors. These materials are engineered by integrating conductive fillers into a polymer matrix to enhance their ability to detect stress or strain while preserving their mechanical properties. Nano-conductive materials possess the potential to revolutionize traditional paving materials in terms of performance and applications. In this study, epoxy resin was selected as the base material due to its favorable physical and chemical characteristics. Multi-walled carbon nanotubes (MWCNTs) were chosen as the conductive filler to formulate a MWCNTs/Epoxy mixture. The dispersion impact of the high-speed shear method on MWCNTs was verified. Subsequently, a hybrid resistance measuring method was developed using conductive copper foil as an electrode. An exploratory investigation was conducted to evaluate the piezoresistive response of MWCNTs/Epoxy mixtures under varying temperatures and loading frequencies. The study revealed that the MWCNTs content near the percolation threshold yields an improved piezoresistive response. The gauge factor of MWCNTs/Epoxy mixtures is up to 150, which is much higher than that of conductive asphalt mixture. Furthermore, the mixture exhibited robust and consistent piezoresistivity across different temperatures (ranging from 0°C to 60°C) and loading frequencies (ranging from 1 Hz to 10 Hz).