Urban informal settlements in the Global South, home to over a billion people, face significant challenges due to limited space and inadequate Water, Sanitation, and Hygiene (WASH) and Solid Waste Management (SWM) infrastructure. These deficiencies significantly impact women's ‘triple care role’—reproductive, productive, and community caregiving responsibilities—within their families, society, and the economy, exacerbated by the COVID-19 pandemic. This study aimed to explore how inadequate infrastructure in three informal settlements in Khulna, Bangladesh, influenced women's caregiving roles during the pandemic and their responses. Through semi-structured interviews with 24 women community leaders, who served as front-line workers during COVID-19, and supporting fieldwork, we discovered that women adapted by modifying their habits and the spatial layouts of their homes for isolation. Although some improvements were noted in WASH and SWM conditions, significant challenges remained, particularly in temporary housing, household adaptability, and reproductive responsibilities Despite facing informal employment, financial constraints, and food insecurity, women showed resilience through leadership, socio-political networking, and community initiatives. This study underscores the urgent need for adaptive infrastructure planning to improve living conditions in informal settlements, with a focus on proactive management of both spatial and non-spatial resources to enhance adaptation in resource-scarce contexts.