Objective: Describe the epidemiological, diagnostic and therapeutic profile of breast cancer in Senegal. Patients and Methods: One hundred and sixty patients with histological confirmation of breast cancer, treated consecutively between June 2018 and December 2020, were retrospectively included. Predefined clinical data were extracted from medical records containing patient demographic information, medical history, diagnostic features, and different treatment types. Data were collected, entered and analyzed using SPSS version 23.0 software. Results: The median age of the participants was 48 years with extremes of 27 and 81 years. The average consultation time was 4 (± 2.6) months. Breast cancer was mainly discovered to clinical signs (91.3%). Screening mammography revealed only 5% of cases. The vast majority of patients had a tumor larger than 3 cm (78.2%). Molecular characterization by immunohistochemistry was studied in 87 patients (54.3%) with a predominance of the triple negative profile (36.8%). Neoadjuvant chemotherapy was performed in 111 patients (74%). One hundred and thirty-five patients (92.5%) had undergone a mastectomy with modified Patey type dissection and only 11 patients (7.5%) had conservative treatment. The histological complete response rate after neoadjuvant chemotherapy was 17.1%. The median time between surgery and radiotherapy was 6 months. All patients in the series received radiotherapy. It was adjuvant in 142 patients and exclusive for palliative purposes in 18 patients. It was moderately hypofractionated in 105 patients (65.6%); classic in 52 patients (32.5%). Acute toxicities of radiotherapy were mainly represented by grade 1 radiodermatitis (22.5%). Conclusion: The descriptive analysis of these results shows the young age of the patients, the late diagnosis of breast cancer in our context and a treatment which is essentially based on neo-adjuvant chemotherapy and radical mastectomy.