Triglyceride Profiles Research Articles

Chronic low-grade inflammation in patients with systemic sclerosis is associated with increased risk for arteriosclerotic cardiovascular disease.

Vasculopathy is a hallmark of systemic sclerosis (SSc) putting patients at an increased risk of cardiovascular disease. Approximately 20-25% of all SSc patients show prolonged elevated C-reactive protein (CRP) levels and thus signs of chronic low-grade inflammation. While CRP-positivity is an independent predictor of cardiovascular disease in non-SSc populations, the relationship between CRP-positivity and cardiovascular health/atherosclerosis in SSc patients is only incompletely understood. Here, we aimed to assess (1) which general, SSc disease-specific and cardiovascular parameters are associated with CRP-positivity in a cohort of SSc patients with prolonged CRP elevations (CRP+ SSc group) relative to SSc patients without CRP elevations (CRP- SSc group). In addition (2), we aimed to investigate whether prolonged CRP-positivity in SSc patients is associated with a higher cardiovascular risk and an increased atherosclerotic burden. We also aimed to (3) identify via random forest classification modeling which combined cardiovascular and/or SSc-specific parameters could differentiate best between SSc patients with elevated CRP levels (the so-called "inflammatory SSc subtype") and SSc patients without increased CRP levels. Sixty-five SSc patients were recruited and assigned to the CRP+ SSc group (n = 20) if their CRP levels were > 5 mg/L in at least three half-yearly visits within 2 years before enrolment or to the CRP- SSc group (n = 45), respectively. All patients underwent an anamnesis, physical examination, blood draw, and bilateral carotid ultrasound in order to assess arteriosclerotic burden including the presence, number and height of plaques, and carotid intima-media thickness (CIMT) as well as lipid profiles. 10-year ASCVD risk was estimated via the ASCVD risk estimator plus. Statistical evaluation included Spearman's correlations, logistic regression and random forest modeling under 5-fold cross-validation, and permutation testing to determine combinations of cardiovascular variables highly discriminatory for CRP-positivity. SSc groups showed comparable mean age, height, and extent of SSc organ involvement. Regarding cardiovascular health, CRP+ SSc patients exhibited a significantly altered HDL-, LDL-, and triglyceride profile (0.001 ≤ p ≤ 0.017) and a significantly higher 10-year ASCVD risk (p = 0.047), relative to CRP- SSc patients. Additionally, within the subgroup of CRP+ SSc patients, positive correlations between CRP levels and CIMT right (ρ = 0.657, p = 0.002) and mean CIMT left and right (ρ = 0.497, p = 0.026) were seen. Combined ROC models identified the four lipid components (HDL, LDL, total cholesterol, and triglycerides) or the SSc duration and ASCVD category to differentiate with high cross-validated ROC-AUCs (AUC: 0.83 ± 0.15, and AUC: 0.86 ± 0.09, p < 0.001) for prolonged CRP-positivity among SSc patients. Our data indicate that persistent CRP-positivity and thus chronic low-grade inflammation in SSc patients enhance the risk for arteriosclerotic-cardiovascular disease significantly beyond the ASCVD risk observed for our SSc patients without CRP elevations. It seems to be along with a disrupted lipid profile the hallmark of a distinct "inflammatory" subgroup of SSc patients. However, large population-based studies and clinical trials in patients with SSc are needed to validate our findings in a prospective or interventional setting.

Serum Biochemical Profile, Intestinal and Liver Histomorphometry of Captive Broad-Snouted Caiman (Caiman latirostris) Fed With a Diet Enriched With Soybean (Glycine max).

The impact of plant-based diets on crocodilians is unclear. Serum profiles and histomorphometry provide valuable insights into their nutritional and physiological status. This study aims to elucidate the impact of three levels of soybean meal substitution combined chicken by-product minced on the growth and health of broad-snouted caiman (Caiman latirostris). The research assesses the effects of diets supplemented with soybean meal on the blood biochemical profile, intestinal histomorphometry, and hepatic parameters of C. latirostris, providing essential information for understanding on the implications of dietary changes in this species. Forty-eight 6-month-old broad-snouted caimans were assigned to three dietary groups (0%, 25%, 40% soybean meal). Over a period of 90 days, data on growth, food consumption, serum biochemical analysis, intestinal and hepatic morphometry were recorded. The results showed that diets containing higher levels of soybean meal did not significantly affect growth, feed intake or serum profiles of total protein, albumin and cholesterol. However, changes in intestinal morphology were observed, with longer and wider villi in the animals feed with diets with soybean meal, indicating a gradual adaptation to new feeding diets. The presence of soybean meal reduced serum glucose and triglyceride profiles and hepatic lipid accumulation without affecting macronutrient digestion and absorption, considered beneficial for the caiman's health. This study provides valuable insights into the inclusion of soybean meal in the diet of Caiman latirostris and its effects on the intestines, liver, and physiology. It also highlights the importance of considering nutritional management as a key tool in improving the well-being and health of crocodilians in captivity.

Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions

Guinea pigs in intensive production generates an imperative necessity of physio-pathological bases for diagnosing their state of welfare, health, and production; those which are available for this species are referred to as laboratory or companion animal. The aim of this research is to determine changes in hematological and blood metabolites profiles in relation to age of Cavia porcellus reared in intensive system at 660 masl in humid tropic. For this purpose, forty 15-120 days old guinea pig in healthy conditions from the inti x Peru lines born in the humid tropic were used and the evaluation ages were 15-21, 22-35, 36-60 and 61-120 days. Blood samples were obtained by puncture of the cephalic vein; profiles of erythrocytes (RBC), total leucocytes (WBC), lymphocytes, granulocytes, hematocrit, hemoglobin, MCV, MCH and MCHC indices were determined. In serum, profiles of glucose, total protein (TP), albumin, total cholesterol (TC), triglycerides, total bilirubin (TB), and direct bilirubin (DB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Hemoglobin profile, MCH and MCHC indices increased as age increased (p &lt; 0,05) and the erythrocytes, leucocytes, hematocrit, hemoglobin profiles and MCV, MCH, MCHC indices showed the narrower interval ranges in the 15-35and 61-120-days old guinea pigs. Profiles of TP, DB and AST showed increase with age (p &lt; 0,05) and the DB, AST, ALT, and TC profiles showed the narrower interval range at 36-120 days old. The hematological and blood metabolites profiles of guinea pigs raised in intensive system in humid tropical conditions show significant changes with production age. .

High-Fat Feeding Alters Circulating Triglyceride Composition: Roles of FFA Desaturation and ω-3 Fatty Acid Availability.

Hypertriglyceridemia is a risk factor for type 2 diabetes and cardiovascular disease (CVD). Plasma triglycerides (TGs) are a key factor for assessing the risk of diabetes or CVD. However, previous lipidomics studies have demonstrated that not all TG molecules behave the same way. Individual TGs with different fatty acid compositions are regulated differentially under various conditions. In addition, distinct groups of TGs were identified to be associated with increased diabetes risk (TGs with lower carbon number [C#] and double-bond number [DB#]), or with decreased risk (TGs with higher C# and DB#). In this study, we examined the effects of high-fat feeding in rats on plasma lipid profiles with special attention to TG profiles. Wistar rats were maintained on either a low-fat (control) or high-fat diet (HFD) for 2 weeks. Plasma samples were obtained before and 2.5 h after a meal (n = 10 each) and subjected to lipidomics analyses. High-fat feeding significantly impacted circulating lipid profiles, with the most significant effects observed on TG profile. The effects of an HFD on individual TG species depended on DB# in their fatty acid chains; an HFD increased TGs with low DB#, associated with increased diabetes risk, but decreased TGs with high DB#, associated with decreased risk. These changes in TGs with an HFD were associated with decreased indices of hepatic stearoyl-CoA desaturase (SCD) activity, assessed from hepatic fatty acid profiles. Decreased SCD activity would reduce the conversion of saturated to monounsaturated fatty acids, contributing to the increases in saturated TGs or TGs with low DB#. In addition, an HFD selectively depleted ω-3 polyunsaturated fatty acids (PUFAs), contributing to the decreases in TGs with high DB#. Thus, an HFD had profound impacts on circulating TG profiles. Some of these changes were at least partly explained by decreased hepatic SCD activity and depleted ω-3 PUFA.

Characterization of lipid composition and physicochemical properties of clarified yak milk fat

In the present study, the samples of clarified milk fat (CMF) of yak species (Arunachali yak and yak-cow hybrid) were collected and analysed for physicochemical parameters, colour values, fatty acid composition and triglyceride profile, and FT-IR characteristics. The obtained results showed that CMF contains a variable amount of moisture (0.25 %–20.28 %), free fatty acid (0.12–2.03 % oleic acid), peroxide values (0.30–1.20 meq.O2/kg fat), Reichert Meissl value (19.06–23.54) and Butyro-Refractrometer reading (43.03–44.47). The colour value (L*, a*, b*) varied with altitude level and region significantly (p < 0.05). The regional variations in triglycerides and fatty acid profile of CMF were also found significantly (p < 0.05). The preliminary data of FT-IR spectra of all samples showed almost similar functional groups but slight difference in the absorbance as well as peaks in the finger print region.

516-P: High-Fat Feeding Alters Circulating Triglyceride Profile by Decreasing SCD Activity and Depleting n-3 Fatty Acids

516-P: High-Fat Feeding Alters Circulating Triglyceride Profile by Decreasing SCD Activity and Depleting n-3 Fatty Acids

EVALUATION OF CARDIOVASCULAR RISK FACTORS IN CHILDREN AGED 6-16 YEARS OLD AND THEIR EVOLUTION AT EARLY ADULTHOOD IN A 10-YEAR FOLLOW UP STUDY

Objective: Objective: Obesity and arterial hypertension in children represent well recognized main risk factors for cardiovascular (CV) events during adult life. We aimed to investigate any changes regarding several CV risk (CVR) factors of children aged 6-16 years old after a 10-year follow-up period. Design and method: Design and method: A cohort of 143 healthy children 6-16 years old (79/64 boys/girls, aged 9±2 years) was initially evaluated regarding CVR factors [obesity, blood pressure (BP), aortic stiffness, lipid profile] plus food habits/sports activity. At 10-years follow-up, 62/143 (43%) young adults were re-evaluated (33/31 boys/girls, aged 20±2 years old). Results: Results: Obesity, found in 45% of children, was accompanied by increased BP (p&lt;0.001) and a less favorable low density lipoprotein cholesterol (LDL-C)/triglycerides profile (p=0.001). In a 10-year follow-up, obesity and exercise improved (p&lt;0.001 and p=0.005), BP was elevated (p&lt;0.001) at levels of high normal (40% of young adults), aortic stiffness increased (p&lt;0.001), LDL-C and high density lipoprotein cholesterol (HDL-C) decreased (p=0.004 and p&lt;0.001), triglycerides increased (p=0.04), and food approached the western model of nutrition (less fish/fruits). In children and young adults, body mass index (BMI) was associated with age (Beta=0.47, p&lt;0.001 and Beta=0.36, p=0.004), systolic BP (Beta=0.46 and Beta=0.52, p&lt;0.001), and LDL-C (Beta=0.27 and Beta=0.44, p&lt;0.001). Conclusions: Conclusions: An increased incidence of obesity associated with systolic BP and accompanied by a less favorable lipid profile was found in children. At 10-years re-evaluation, obesity was partly improved, systolic BP had reached the high-normal levels in a substantial number of young adults while lipid profile was less favorable compared to baseline evaluation. Our results highlight the evolution of CVR factors from childhood to early adulthood.

Evaluation of Single/Multiple Joint Effects of Lipid Profiles on Hypertension, Diabetes Mellitus and Obesity Accompanying Coronary Artery Disease

Objective: Although cardiovascular diseases are among the most prominent causes of mortality/morbidity in the world, they are even more important together with comorbidities. This study aims to reveal the single/multiple effects of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) on hypertension (HT), type 2 diabetes mellitus (T2DM) and obesity accompanying coronary artery disease (CAD). Method: The data were retrospectively achieved from the records of CAD patients undergoing coronary bypass surgery at the Department of Cardiovascular Surgery, Medical Center, University. The medical knowledge discovery process (MKDP) was applied to the data concerning HT, DM, obesity, TC, HDL-C, LDL-C, and TG variables. Different methods were used to determine the optimal cut-off points of lipid profiles. Logistic regression analysis (LRA) was examined the single/multiple effects of lipid profiles on HT, T2DM, and obesity. Results: TC, LDL-C, TG, and HDL-C lipid profiles categorized according to the cut-off points determined in the current study were analyzed with LRA models. LDL-C (&gt;117 mg/dL)*TC (&gt;191 mg/dL)*HDL-C (&gt;37.2 mg/dL) in HT and TC (&gt;190 mg/dL)*TG (&gt;197) mg/dL)*HDL-C (&gt;36.3 mg/dL) in T2DM interaction terms had a moderate effect size. LDL-C (&gt;115 mg/dL)*TG (&gt;197 mg/dL)*HDL-C (&gt;36.3 mg/dL) interaction terms in T2DM and TC (&gt;192 mg/dL)*LDL-C (&gt;117 mg/dL)*HDL-C (&gt;36.8 mg/dL), TK (&gt;192 mg/dL)*TG (&gt;193 mg/dL)*HDL-C (&gt;36.8 mg/dL) and LDL-C (&gt;117 mg/dL)*TG (&gt;193 mg/dL)*HDL-C (&gt;36.8 mg/dL) interaction terms in obesity were reported as having a high effect size. Conclusion: In conclusion, it is recommended to use the approach that analyzes the cut-off points proposed in this study for lipid profiles in predicting HT, T2DM, and obesity.

Exploring the cholesterol-lowering effects of cereal bran cell wall-enriched diets.

Cell wall polysaccharides (dietary fiber) in cereal grains contribute to health benefits. The novelty of the current study was an effort to explore the invivo therapeutic potential of different cereal bran cell walls against hypercholesterolemia. For this purpose, the cell walls were isolated from different cereal brans (wheat, maize, oats, and barley), and the intake of these cereal bran cell walls was evaluated for their anti-lipidemic activity in normal and hypercholesterolemic rats. The serum taken from the rats was tested for cholesterol, lipid, and triglyceride profiles before and after treatment. The outcomes of the current study have shown that the cereal cell wall has a significant hypercholesterolemia effect. The biochemical parameters of the control animals were within the normal clinical ranges, indicating that the experimental diets were safe. Among cereal bran cell walls, barley bran significantly decreased cholesterol (56.35 ± 1.35 mg/dL), low-density lipoprotein (56.35 ± 1.05 mg/dL), triglycerides (105.29 ± 1.95 mg/dL), and increased high-density lipoprotein level (48.35 ± 1.35 mg/dL). These findings provide conclusive evidence that the cereal cell wall is beneficial in the treatment of hypercholesterolemia and may potentially provide protection against other acute, recurring, or chronic illnesses.

Study of triglyceride changes during pregnancy and neonatal birth weight and adverse outcomes.

Changes of maternal triglyceride concentrations are closely associated with intrauterine fetal growth and development, but the effect of mid- to late-term triglyceride changes on birth weight is uncertain. This study investigated the association between changes in triglycerides in mid to late in pregnant women gestational age ≥ 35 weeks on neonatal birth weight and adverse outcomes. This cohort study was based on 931 pregnant women with a singleton delivery at gestational age ≥ 35 weeks from January 1, 2022 to December 31, 2022 at Nanjing Lishui People's Hospital (NJLSPH) in China, with all maternal triglyceride concentrations measured at mid-term and late-term before delivery. The primary outcomes were neonatal birth weight and the risk of macrosomia. Late term triglyceride levels were positively associated with birth weight (β = 126.40, 95% CI: 61.95, 190.84, p < .001) and risk of macrosomia (OR = 2.11, 95% CI: 1.12, 3.98, p = .022). Late mid-term triglyceride was positively associated with birth weight (β = 27.58, 95% CI: 9.67, 45.50, p = .003), and no correlation with risk of macrosomia (OR = 1.12, 95% CI: 0.95, 1.31, p = .178). Mid-term triglyceride was not associated with birth weight (β = 45.79, 95% CI: -28.73, 120.30, p = .229) and risk of macrosomia (OR = 1.83, 95% CI: 0.89, 3.78, p = .101). Late triglyceride levels were associated with birth weight and risk of macrosomia, while late to mid-term triglyceride were associated with birth weight but not with risk of macrosomia. This suggests that maternal triglyceride changes may affect fetal growth and development, and more studies focusing on the effects of gestational triglyceride profiles are warranted.

The effect of variations in coffee and tiwai plants as drink products on blood lipid profiles and hematological indices

Plants or spices can be processed into herbal drinks as an alternative to traditional medicine. Using existing local resources, it is possible to produce functional food in the form of drinks. Tiwai coffee (TC) is a drink made by mixing Tiwai onion powder (TP) with coffee powder (CP), sugar, and salt. Therefore, this research aims to determine the effect of administering TC, ground coffee, green coffee (GC), TP, and instant Tiwai (IT) on lipid profiles of cholesterol, LDL, HDL, and triglycerides, hematological indices of Hb, erythrocytes (RBC), leukocytes (WBC), and hematocrit (HCT), glucose, heart rate, and body temperature in mice. Furthermore, a post-test-only control group design was applied with six treatment types and seven replications. The data were analysed using ANOVA and once a significant difference was discovered, the Tukey’s with a 5% level was subsequently conducted. The administered products had a significant effect only on HDL, TG, WBCs, and body temperature, excluding other parameters. In general, it is best to give green coffee. In general, the best treatment is giving green coffee, especially when increasing immunity as indicated by the lowest WBCs value.

Effects on cardiovascular risk factors of a low- vs high-glycemic index Mediterranean diet in high cardiometabolic risk individuals: the MEDGI-Carb study.

The role of dietary Glycemic Index (GI), independently of fiber intake, in modulating cardiovascular disease (CVD) risk among non-diabetic individuals has not been fully elucidated. To evaluate the effects of a low- versus a high-GI diet, based on a Mediterranean dietary pattern, on cardiometabolic risk factors in individuals at high CVD risk, participating in the MEDGI-Carb intervention study. 160 individuals, aged 30-69 years, BMI 25-37 kg/m2, with a waist circumference >102 cm (males) or >88 cm (females) and one feature of the metabolic syndrome, participated in a multi-national (Italy, Sweden, USA) randomized controlled parallel group trial. Participants were assigned to a low GI (< 55) or high-GI MedDiet ( > 70) for 12 weeks. The diets were isoenergetic and similar for available carbohydrate (270 g/d) and fiber (35 g/d) content. Fasting metabolic parameters were evaluated in the whole cohort, while an 8-h triglyceride profile (after standard breakfast and lunch) was evaluated only in the Italian cohort. Blood pressure and most fasting metabolic parameters improved at the end of the dietary intervention (time effect, p < 0.05 for all); however, no differences were observed between the low- and the high-GI MedDiet groups (time x group effect; p > 0.05 for all). Conversely, the low-GI diet, compared with high-GI diet, significantly reduced the 8-h triglyceride profile (p < 0.017, time*group effect) that was measured only in the Italian cohort. However, it induced a reduction of plasma triglycerides after lunch (tAUC) that was of only borderline statistically significance (p = 0.065). Consuming a low-GI in comparison with a high-GI MedDiet does not differentially affect the major cardiometabolic risk factors at fasting in individuals at increased cardiometabolic risk. Conversely, it could reduce postprandial plasma triglycerides. NCT03410719, ( https://clinicaltrials.gov ).

Triglyceride and fatty acid composition of bovine colostrum and transition milk in pasture‐based dairy cows supplemented prepartum with inorganic selenium, organic selenium or rumen‐protected choline

The objectives of this study were to determine the effects of prepartum supplementation with inorganic selenium (INORG), organic selenium (ORG) or a rumen‐protected choline, on the triglyceride (TAG) and total fatty acid (TFA) profiles of bovine colostrum and transition milk. Fifty‐seven Holstein Friesian (HF) and HF × Jersey cows were supplemented daily from 49 ± 12.9 days prior to calving until day of calving. Milk samples were analysed for TAG and TFA composition using GC‐FID. Prepartum supplementation did not have a significant effect on the milk lipid profiles. This study quantified colostrum lipids not previously reported in the literature.

Comparative analysis of triglyceride profiles in human milk from Egyptian and Chinese women across lactation stages

Understanding human milk triacylglycerols (TAGs) provides valuable insights for infant formula development. This study utilized ultra-performance supercritical fluid chromatography to investigate how lactation stages and maternal diet affect TAG profiles. 18:1/16:0/18:1 (O/P/O), 16:0/18:1/16:0 (P/O/P), and 18:1/16:0/18:2 (O/P/L) were most abundant in human milk, accounting for 20% of the total TAGs. Furthermore, significant differences in TAG compositions were observed across the three stages of lactation. Also, there are apparent differences in the TAG of Egyptian and Chinese human milk. Egyptian human milk exhibited higher levels of TAGs esterified with three saturated fatty acids (SSS), TAGs esterified with two saturated fatty acids, and one unsaturated fatty acid (S2U), and total palmitic acid compared to Chinese human milk. On the other hand, TAGs with three long-chain fatty acids (LLL) and TAGs with three unsaturated fatty acids (UUU) were at higher levels in Chinese human milk. Understanding the prevalence of these specific TAGs, particularly related to O/P/O, can help in formulating infant formulas that aim to mimic the composition of human milk more accurately.

The effect of alpha-lipoic acid supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in individuals with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.

This systematic review and meta-analysis aimed to examine the effect of the antioxidant alpha-lipoic acid (ALA) on various cardiometabolic risk factors and hormonal parameters in patients with polycystic ovary syndrome (PCOS). We searched PubMed, EMBASE, SCOPUS, Cochrane Library, and Web of Science databases without language restrictions until May 2023 to find randomized controlled trials (RCTs) that assessed the impact of ALA supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in women with PCOS. Outcomes were summarized using the standardized mean difference (SMD) and 95% confidence interval (CI) in a random-effects model. An I2 statistic of >60% established significant between-study heterogeneity. The overall certainty of the evidence for each outcome was determined using the grading of recommendations, assessment, development, and evaluations system. Seven RCTs met the inclusion criteria. The ALA group had significant reductions in fasting blood sugar (fasting blood sugar (FBS), n=7 RCTs, SMD, -0.60; 95% CI, -1.10 to -0.10; I2=63.54%, moderate certainty of evidence) and homeostatic model assessment for insulin resistance (homeostatic model assessment of insulin resistance (HOMA-IR), n=4 RCTs, SMD, -2.03; 95% CI, -3.85 to -0.20; I2=96.32%, low certainty of evidence) compared with the control group. However, significant differences were observed between the groups in body mass index, insulin, estrogen, follicle-stimulating hormone, luteinizing hormone, testosterone, low-density lipoprotein, highdensity lipoprotein, triglyceride, total cholesterol, malondialdehyde, or total antioxidant capacity profiles. ALA supplementation improves FBS and HOMA-IR levels in women with PCOS. ALA consumption is an effective complementary therapy for the management of women with PCOS.

Influence of seed-roasting degree on quality attributes of sunflower oil.

To facilitate the typical flavor of sunflower oil, seed roasting is widely applied. In this study, the effects of seed-roasting degree (160, 180, 200°C for 0-25min) on the quality attributes of sunflower oil were assessed, particularly tocopherols, sterols, total phenolics, fatty acids, and triglycerides composition as essential compounds for the nutritional value of the sunflower oil. Roasting seeds at a high temperature can significantly raise oxidative stability by 1.5-1.8 times, the content of carotenoids by 2.0-5.5 times, chlorophyll by 7.5-17.0 times, as well as increase the browning index by 4.0-10.0 times and deepen the color of the sunflower oil. However, the fatty acid and triglyceride profiles of sunflower oils have little change under distinct seed-roasting degrees. Synthetically considering the various indicators measured in the current study. It is recommended that the seed roasts at 160-180°C for about 20 min to ameliorate the oxidative stability and quality. Practical Application: A well-defined roasting process is very important for the food industry to be able to produce sunflower oil with desirable nutrition, unique flavor produced by the Maillard reaction and chemical properties of sunflower oil, which changes during the roasting. Considering the flavor, peroxide values, oxidation stability, and other quality attributes of oil obtained from the roasted seed, we found that sunflower seed oil better quality is obtained when roasted at 160- -180°C for about 20 min (e.g., 160°C for 20-25 min or 180°C for 15-20 min).

Dietary intakes of branched-chain amino acids and plasma lipid profiles among filipino women in Korea: the Filipino Women’s Diet and Health Study (FiLWHEL)

BackgroundThe potential role of dietary branched-chain amino acids (BCAA) in metabolic health, including cardiovascular disease and diabetes, is evolving, and it is yet to be understood if dietary BCAA intakes are associated with plasma lipid profiles or dyslipidaemia. This study tested the association of dietary BCAA intakes with plasma lipid profiles and dyslipidaemia among Filipino women in Korea.MethodsEnergy-adjusted dietary BCAA intakes (isoleucine, leucine, valine, and total BCAA) and fasting blood profiles of triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were determined in a sample of 423 women enrolled in the Filipino Women’s Diet and Health Study (FiLWHEL). The generalized linear model was applied to estimate least-square (LS) means and 95% confidence intervals (CIs) and compare plasma TG, TC, HDL-C, and LDL-C across tertile distribution of energy-adjusted dietary BCAA intakes at P < 0.05.ResultsMean of energy-adjusted dietary total BCAA intake was 8.3 ± 3.9 g/d. Average plasma lipid profiles were 88.5 ± 47.4 mg/dl for TG, 179.7 ± 34.5 mg/dl for TC, 58.0 ± 13.7 mg/dl for HDL-C, and 104.0 ± 30.5 mg/dl for LDL-C. LS means, and 95% CIs across tertiles of energy-adjusted total BCAA intakes were 89.9 mg/dl, 88.8 mg/dl and 85.8 mg/dl (P-trend = 0.45) for TG, 179.1 mg/dl, 183.6 mg/dl and 176.5 mg/dl (P-trend = 0.48) for TC, 57.5 mg/dl, 59.6 mg/dl and 57.1 mg/dl (P-trend = 0.75) for HDL-C and 103.6 mg/dl, 106.2 mg/dl and 102.3 mg/dl (P-trend = 0.68) for LDL-C. Furthermore, the multivariable-adjusted prevalence ratios and 95% confidence intervals for dyslipidaemia across increasing tertile distribution of energy-adjusted total BCAA intake were; 1.00, 0.67 (0.40, 1.13) and 0.45 (0.16, 1.27; P-trend = 0.03) for the first, second and third tertile, respectively.ConclusionsHigher dietary intakes of BCAA presented a statistically significant inverse trend with the prevalence of dyslipidaemia among Filipino women in this study and testing these associations in longitudinal studies may be necessary to confirm these findings.

Hypertriglyceridemia associated with the use of capecitabine in a Mexican cohort.

e24107 Background: Capecitabine is a prodrug activated to its cytotoxic form 5-fluorouracil by thymidine phosphorylase whose active metabolites inhibit DNA synthesis by reducing thymidine production and also inhibits RNA and protein synthesis by competing with uridine triphosphate. Capecitabine is used in many types of tumors and its main reported side effects are diarrhea, hand-foot syndrome and hematologic toxicity. Methods: Retrospective analysis of a cohort of patients visited in a private hospital in Mexico City, that has a basal triglyceride profile and at least two determinations during treatment with capecitabine with or without oxaliplatin. Results: We analyzed 14 patients with a mean age of 55 years (IQR 40-73), 12 patients with colorectal cancer, 78.5% in the adjuvant setting, a half of patients with capecitabine monotherapy and the other half in combination with oxaliplatin. Comorbidities as overweight/obesity were seen in a half of the patients, diabetes in 21.4% and hypertriglyceridemia at baseline in 57.1% of patients all of them G1. The mean baseline glucose was 99.5 mg/dl (IQR 74-174), the mean baseline cholesterol was 180.8 mg/dl (IQR 85-243), the mean baseline triglycerides was 153.3 mg/dl (IQR 85-243). During capecitabine treatment a total of 85.7% of patients developed hypertriglyceridemia: G3/4 of 21.4%, G2 of 28.5%, G1 of 35.7%. No patient developed a serious complication associated with hypertriglyceridemia such as pancreatitis. There was no association between monotherapy or combination treatment with oxaliplatin, of patients with grade ≥2 hypertriglyceridemia, five received capecitabine monotherapy and two in combination with oxaliplatin. Also, no association was found among the highest levels of cholesterol, glucose, disease stage, age or body mass index. All of the 6 patients with normal baseline triglycerides developed hypertriglyceridemia 66.6% G1 and 33.3% G2. All the patients who present with hypertriglyceridemia G3/4 had baseline hypertriglyceridemia and 66.6% also diabetes. Conclusions: This analysis shows the high prevalence of hypertriglyceridemia associated with the use of capecitabine as monotherapy or combined with oxaliplatin in a Mexican cohort, with an incidence of 21.4% of hypertriglyceridemia G3/4 having the pre-existing hypertriglyceridemia and diabetes as risk factors. The cause of the worsening of the lipid profile requires more research but justify lipid profile at baseline and during the treatment with capecitabine. Due to the small size of the sample, the findings need to be confirmed with a prospective study with a larger number of patients.

Study of Correlation between Used Cooking Oil and Triglyceride Profile on Hypertension in Coastal Communities in Nambo Village, Kendari

Background: According to the World Health Organization (WHO) in 2008, in Southeast Asia, as many as 36% of adults aged 25 years and over had high blood pressure, and 1.5 million deaths occur each year due to complications of high blood pressure. In Indonesia, hypertension is still a big challenge. This is a health problem with a high prevalence of 25.8% according to Riskesdas data in 2013. Hypertension is a chronic increase in blood pressure 140/90 mmHg. Non-pharmacological therapy needs to be applied to prevent the occurrence of hypertension, namely by modifying lifestyle to control blood pressure. Used cooking oil contains free fatty acids formed from the process of oxidation and hydrolysis, then these free fatty acids reshape saturated fatty acids and trans fatty acids and free radicals, which can cause various disorders such as endothelial dysfunction, which can lead to hypertension. Purpose(s): The purpose of this study was to determine the correlation between the used cooking oil and triglyceride profile with hypertension. Methods: The design of this study was observational analytic with cross-sectional research design. The sample of this study amounted to 96 people with purposive sampling technique. The instrument of this study was Questionnaire to determine the used cooking oil and automatic Spectrophotometer (TRX-7010) to measure triglyceride profiles. Data analysis was performed by chi-square test with significance value p &lt; 0,05. Results: The results of this study showed that there was a correlation between the used cooking oil and hypertension (p = 0.002) and triglyceride profile with hypertension (p = 0.004). Conclusions: Hypertension had a correlation with the used cooking oil and increase in triglycerideprofile.Keywords : Hypertension., triglyceride profile, used cooking oil&#x0D; &#x0D;

Exploration and biological evaluation of 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one as an activating transcription factor 3 inducer for managing metabolic syndrome

The induction of activating transcription factor 3 (ATF3) was identified as a promising therapeutic mechanism to overcome metabolic syndrome. Hence, a structure-activity relationship campaign on the chiral lead (1b) was conducted with a scaffold-hopping approach, whereby achiral 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one (16c) was recognized as a potential ATF3 inducer with a lipid-lowering feature in a pre-differentiated 3T3-L1 cell model. Also, in a high-fat diet scenario, mice subjected to 16c demonstrated robust weight loss with shrinkage of the white adipose mass and fewer hypertrophic adipocytes, accompanied by a preferable glycemic profile compared to 1b. Additionally, the biochemical analysis revealed that 16c further ameliorated the liver function and improved the plasma triglyceride profile that were absent from mice treated with 1b. Taken together, 16c shows promise as an ATF3 stimulant for further development to alleviate metabolic syndrome.