Tribal Population Of Central India Research Articles

<!DOCTYPE html> <html> <head> </head> <body> Background: The magnitude of tuberculosis (TB) and associated risk factors for development of toxicity to anti-TB drugs in vulnerable tribal groups are useful indicators for understanding extent of TB transmission, effectiveness of TB therapy. Such studies help to gather information, helps in planning control and preventive strategies for TB in this special population. The study was carried out to evaluate incidence of hepatotoxicity, association between risk factors, anti-TB regimen and hepatotoxicity in selected vulnerable population. Materials and Methods: Prospective study in tribes (Gond, Halba, Kawar) of a district in central India diagnosed with pulmonary/ extrapulmonary/Multi drug resistant TB. These patients were on anti- TB regimen, monitored clinically and biochemically for hepatotoxicity at the end of 1, 3 and 6 months of anti-tubercular therapy. A specific criterion was set for diagnosing hepatotoxicity. Results: Incidence of hepatotoxicity was 9.23%. Raised serum transaminase, bilirubin level and symptoms of hepatotoxicity like nausea, anorexia, vomiting, malaise, jaundice, were observed. The onset of hepatotoxicity ranged from 25-180 days (median 65 days). Of various risk factors analyzed, high alcohol intake was associated with hepatotoxicity (odds ratio = 9.3, 95% confidence interval 1.8–47, p=0.003). Age, gender, extent of tuberculosis disease, malnutrition was not significantly associated with anti-tuberculosis treatment hepatotoxicity. Relative risk of developing hepatotoxicity in alcoholic addicted males was 14.117. Conclusion: Withdrawal of alcohol habit in selected tribes on anti- Tuberculosis regimen will cause a drop in developing hepatotoxicity by 93%. Mass education regarding same would curtail hepatotoxicity making therapy safe. Key words: Directly observed treatment shortcourse, Ethambutol, Isoniazid, Pyrazinamide, Rifampicin. </body> </html>

To assess the therapeutic efficacy of chloroquine (CQ) treatment against uncomplicated Plasmodium falciparum infections in a tribal population of central India (Madhya Pradesh) and to investigate the prevalence of mutant P. falciparum chloroquine-resistant transporter (pfcrt) gene in the parasite population. Clinical and parasitological response was determined by in-vivo testing. For molecular testing, the parasite DNA was extracted from blood samples and used to amplify and sequence parts of the pfcrt (44-177 codons), MSP1 (block 2) and MSP2 (central repeat region) genes. Of 463 patients presenting fever, 137 tested positive for P. falciparum. They were treated with CQ. Of these, 58% participated in the study. Overall, treatment failure occurred in 53% of participants. Children under 5 years of age showed significantly more CQ resistance than adults. Mutant genotype S(72)V(73)M(74)N(75)T(76) was prevalent among both CQ responders (61.29%) and non-responders (66.7%). Interestingly, several patients from the CQ non-responder group (33.3%, n = 39) were harbouring parasite with wild type C(72)V(73)M(74)N(75)K(76) genotype of the pfcrt gene. Microsatellite sequences downstream of exon 2 varied widely among both wild type and mutant pfcrt haplotypes. The high rate of treatment failure in the present study clearly indicates the need to reassess the use of CQ as first-line antimalarial therapy in central India. This is supported by the presence of mutant pfcrt genotype among majority of the parasite population of the CQ non-responder group of patients. However, the presence of wild type amino acid at codon 76 of the pfcrt gene among several patients with CQ non-responders requires further investigations.

Tribal Population Of Central India Research Articles

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Tribal Population Of Central India Research Articles

Related Topics

Articles published on Tribal Population Of Central India

Evaluation of Hepatotoxicity of Anti-Tuberculosis Regimens: A Prospective Study in Tribal Population of Central India

Dopamine receptor D2 gene polymorphism and interaction with the body mass index: A study among two tribal populations of Central India

Structure and genetic relationship of five populations from central India based on 15 autosomal STR loci

Genetic variation at 15 autosomal STR loci in Bhil tribal population of Central India

Therapeutic efficacy of chloroquine and sequence variation inpfcrtgene among patients withfalciparummalaria in central India

Sexually transmitted infections in tribal populations of central India

Prevalence of sexually transmitted disease syndromes in tribal population of central India

Sexually Transmitted Diseases in Tribal Population of Central India

Annual risk of tuberculosis infection among tribal population of central India

Seroprevalence of sexually transmitted viruses in the tribal population of Central India

Cercarial dermatitis in central India: an emerging health problem among tribal communities

Study of enzyme polymorphism and haemoglobin patterns amongst sixteen tribal populations of central India (Orissa, Madhya Pradesh, and Maharashtra).