With the proposal of the double carbon target, the exploration, development, and efficient utilization of geothermal energy is an important field for the energy development. Meanwhile, there also exists a series of challenges. With regard to the injection and production process of enhanced geothermal system, researchers mainly focus on the numerical simulation. As the conceptual model is developed based on several assumptions, the results are unable to truly reflect the heat transfer and seepage process of the fluid. Unfortunately, there are few reports on the large‐scale physical simulation experiments. Considering the present research situation, we have developed a large‐scale physical simulation experiment system in which the in situ long‐term injection and production process of hot dry rock (HDR) can be simulated. The experimental system includes several components: high‐temperature and high‐pressure true triaxial chamber and loading system, multiwell injection system, acoustic emission monitoring system, and flow and temperature monitoring system. By designing the experiments, the performance evaluation of the temperature variation, fluid flow, and heat energy extraction in the long‐term HDR injection and production process can be completed. Taking the granite outcrop rock sample, which is from the Gonghe Basin in Qinghai Province, as an example, we have conducted the long‐term injection and production experiment. The production temperature and flow rate were monitored and discussed. The results showed that the experimental system can simulate the heat transfer and seepage process of the fluid. More working conditions can be designed for the research of the long‐term injection and production process. Hopefully, this will provide an experimental platform for the efficient development of HDR.