Objective To evaluate the efficacy of wet cupping in the treatment of postherpetic neuralgia (PHN).Methods One hundred PHN patients were randomized into control group (n=53) (conventional therapies such as anticonvulsants,opioids,superlaser and so on) and wet cupping group (n--47) (wet cupping,on top of conventional therapies.Wet cupping is done first with a triangular needle pricking the skin briefly.Later vacuum tank was immediately placed on the skin so that,air extraction helped to suction the blood out.Wet cupping was administered,twice per week,lasting 4 weeks).Pain intensity was evaluated with visual analogue scale (VAS) before and four week after the treatment.Quality of life was evaluated with SF-36 form (China version),and sleep quality measured by Pittsburgh sleep quality index (PSQI) both before the treatment and after the treatment.Results Compared with before treatment [(8.6 ± 1.4),(8.7 ± 1.3)],the pain score in PHN patients decreased after treatment [(4.1 ± 1.5),(2.2±1.3)] in both group (P<0.05).The rate of pain remission in wet cupping-treated group (74.1±2.3) was higher than that in control group(51.1±2.9) (P<0.05).The sleep quality was improved for both group,especially for the wet-cupping group(5.8±2.8),compared with control group (8.5±1.2),Quality of life for the physical health have the same trend:wet cupping-treated group (67.9±5.5) compare with control group(55.1±6.0).Conclusions wet cupping can improve the efficacy of pain alleviation on top of conventional therapies in the treatment of PHN. Key words: Postherpetic neuralgia; Wet cupping method