The shear strength parameter of an anchoring interface is one of the key parameters affecting the design of bolt support. To better realize the design of bolt support, the pullout model of fully grouted bolts was established by FLAC3D numerical software. The commonly used tri-linear bond-slip model of the anchoring interface was selected. The variable controlling method was used to investigate the effects of the shear strength parameters of the anchoring interface on the bearing performance of fully grouted bolts. The results show that, with the increase in the displacement at the peak shear stress, the bearing capacity and the energy absorption of fully grouted bolts decrease and the ability of the fully grouted anchoring system to resist external loads weakens. Meanwhile, the deformation capacity of fully grouted bolts increases, and the durability of the fully grouted anchoring system is enhanced. With the increase in the residual shear stress and the displacement at the residual shear stress, the bearing capacity and deformation capacity of fully grouted bolts both increase, and the energy absorption also increases. Increasing the post-peak bearing properties of the anchoring interface can help improve the bearing performance of fully grouted bolts and enhance the ability of the fully grouted bolts to resist failure. The results may provide guidance for support design and performance enhancement of fully grouted bolts.