Monitoring areas susceptible to desertification contributes to the strategic development of regions located in environments of extreme hydric and social vulnerability. Therefore, the objective of this study is to evaluate the process of soil degradation in the Desertification Nucleus of Cabrobó (DNC) over the past three decades using remote sensing techniques. This study used primary climatic data from TerraClimate, geospatial data of land use and land cover (LULC), and vegetation indices (SAVI and LAI) via Google Earth Engine (GEE) from Landsat 5/TM and 8/OLI satellites, and established the aridity index (AI) from 1992 to 2022. The results indicated 10 predominant LULC classes with native vegetation suppression, particularly in agriculture and urbanization. SAVI ranged from −0.84 to 0.90, with high values influenced by La Niña episodes and increased rainfall; conversely, El Niño episodes worsened the rainfall regime in the DNC region. Based on the Standardized Precipitation Index (SPI), it was possible to correlate normal and severe drought events in the DNC with years under the influence of El Niño and La Niña phases. In summary, the AI images indicated that the DNC remained semi-arid and that the transition to an arid region is a cyclical and low-frequency phenomenon, occurring in specific periods and directly influenced by El Niño and La Niña phenomena. The Mann–Kendall analysis showed no increasing trend in AI, with a Tau of −0.01 and a p-value of 0.97. During the analyzed period, there was an increase in Non-Vegetated Areas, which showed a growing trend with a Tau of 0.42 in the Mann–Kendall analysis, representing exposed soil areas. Annual meteorological conditions remained within the climatic pattern of the region, with annual averages of precipitation and actual evapotranspiration (ETa) close to 450 mm and an average temperature of 24 °C, showing changes only during El Niño and La Niña events, and did not show significant increasing or decreasing trends in the Mann–Kendall analysis.