Treatment Of Tuberculum Sellae Meningiomas Research Articles

The expanded endoscopic endonasal approach for treatment of tuberculum sellae meningiomas in a series of 40 consecutive cases

Compared with traditional craniotomy, the expanded endoscopic endonasal approach (EEEA) may have some advantages for tuberculum sellae meningioma (TSM) treatment. We described our experience of the therapeutic effect of endoscopic TSM treatment. From August 2015 to December 2019, 40 patients with a TSM were treated by the EEEA in our institution. EEEA outcome in TSM treatment was analyzed. Among 39 patients with visual impairment, 38 (97.4%) improved their visual function to some extent after the EEEA, and one case had no significant change in visual acuity. Among all patients, 38 (95.0%) achieved gross total resection (GTR) and 2 (5.0%) achieved near-total resection (NTR). Cerebrospinal fluid (CSF) leakage occurred in three patients (7.5%) and meningitis (post-CSF leakage) in two patients (5.0%). Eight patients (20.0%) suffered postoperative hyposmia, three of whom developed long-term hyposmia. One patient (2.5%) suffered from bleeding of the branch of the anterior cerebral artery intraoperatively leading to postoperative acute cerebral infarction. The EEEA is a safe and reliable minimally invasive method for TSM removal. Compared with traditional craniotomy, the EEEA may have better visual outcomes and a higher prevalence of GTR, but carries the risk of CSF leakage.

Surgical management of Tuberculum sellae Meningiomas: Myths, facts, and controversies.

The optimal management of tuberculum sellae (TS) meningiomas, especially the surgical strategy, continues to be debated along with several controversies that persist. A task force was created by the EANS skull base section committee along with its members and other renowned experts in the field to generate recommendations for the surgical management of these tumors on a European perspective. To achieve this, the task force also reviewed in detail the literature in this field and had formal discussions within the group. The constituted task force dealt with the practice patterns that exist with respect to pre-operative radiological investigations, ophthalmological and endocrinological assessments, optimal surgical strategies, and follow-up management. This article represents the consensually derived opinion of the task force with respect to the surgical treatment of tuberculum sellae meningiomas. Areas of uncertainty where further clinical research is required were identified.

Surgical resection of tuberculum sellae meningiomas through lateral supraorbital approach: A report of 34 cases

Objective To assess the reliability and safety of lateral supraorbital (LSO) approach in the surgical treatment of tuberculum sellae meningiomas (TSMs). Methods A total of 34 patients underwent operation through LSO approach between June 2013 and June 2017 at Department of Neurosurgery at Qilu Hospital of Shandong University and their clinical data were retrospectively analyzed in this study. All patients underwent surgical resection of the tumor via LSO approach. The extent of resection of the tumor was assessed using the Simpson classification. The effectiveness of the procedure was evaluated based on the patient's postoperative MRI and improvement in neurological symptoms, and the safety of the procedure was assessed based on the occurrence of postoperative complications. Results All patients were followed up for 3-36 months with an average of 12±5 months. Of the 34 patients, 30 underwent Simpson Ⅰ-Ⅱ resection and 4 received Simpson Ⅲ resection. Postoperative visual acuity was improved in 23 cases, no change was reported in 8 cases, and visual impairment was worse than preoperative conditions in 3 cases. There were 3 cases of postoperative fever, 3 cases of hyponatremia, 1 case of psychiatric symptoms, 1 case of cerebral edema, and 2 cases of epileptic seizures. In 1 (3%) patient, postoperative imaging findings confirmed recurrence. Conclusions LSO approach has multiple advantages including simplified and fast skull opening and closing, clean operative field and small trauma, and it could be used in the effective treatment of TSMs. Key words: Meningioma; Microsurgery; Treatment outcome; Lateral supraorbital approach; Tuberculum sellae

Surgical Indications of Exploring Optic Canal and Visual Prognostic Factors in Neurosurgical Treatment of Tuberculum Sellae Meningiomas.

Background:Tuberculum sellae meningiomas (TSMs) present a special symptom because of the adherence and compression to the optic nerve, optic artery, and the chiasm. A significant number of patients with TSMs appear visual deficits. This study aimed to investigate the surgical indications of exploring the optic canal and visual prognostic factors in the neurosurgical treatment of TSMs.Methods:Totally 21 patients with TSM, who were operated from September 2007 to August 2011 in the Department of Neurosurgery, Tongren Hospital were enrolled in this study. Results of orbital computed tomography (CT) and magnetic resonance imaging (MRI), visual acuity, Goldmann visual field test, orbital color Doppler flow imaging (CDI) test in these patients were retrospectively analyzed.Results:Visual deficit and optic canal involvement (OCI) were detected in all the 21 patients. Fourteen patients had bone proliferation within the area of the optic canal. After the operation, visual outcomes were improved in 13 patients, unchanged in 7 patients, and deteriorated in 1 patient. All the 21 patients performed orbital CDI test preoperatively, the results showed that if the peak systolic velocity (PSV) of central retinal artery (CRA) value was ≤8 cm/s, the visual outcome would be better.Conclusions:The surgical indications of exploring optic canal in TSM cases included: (1) The neuroimaging evidences of OCI (CT and/or MRI); (2) PSV of CRA in orbital CDI test was ≤8 cm/s; (3) visual acuity was below 0.1; (4) visual field deficit. The PSV of CRA in CDI test could be a prognostic factor for visual outcomes of TSMs.

Outcome Assessment After Surgical Treatment of Tuberculum Sellae Meningiomas- A Preliminary Report.

To evaluate the endocrinological and ophthalmological results of the tuberculum sellae meningioma surgery. MATRRIAL and METHODS: A total of 18 patients diagnosed with tuberculum sellae meningioma received surgical treatment at Neurosurgery Clinic at Military Medical Institute in Warsaw from January 2010 to July 2012. This analyzed group of patients included 15 females and 3 males at a mean age of 50.5 years (ranging from 30 to 73; SD ± 13.4). In the pre-operative and post-operative periods, all patients underwent magnetic resonance imaging of the head according to a uniform protocol, eye examinations with assessment of visual acuity and field of vision, as well as endocrine tests to evaluate the hypothalamic-pituitary axis (including urine specific gravity and osmolality as well as blood cortisol, TSH, fT3, and fT4 levels). All patients underwent surgical treatment of the tumor via unilateral subfrontal craniotomy, achieving macroscopically complete tumor removal (Simpson grade II resection). The use of the unilateral subfrontal approach helped improve vision in 88% of the treated patients. Endocrine tests revealed no hypothalamic-pituitary axis dysfunction. The most commonly diagnosed meningiomas of the area were meningothelial (77%) and transitional (12%) meningiomas. Surgical treatment of tuberculum sellae meningiomas via the unilateral subfrontal approach is a safe technique with no significant complications. Visual improvement was observed in 88% of the patients who had received this treatment. There were no hormonal disturbances in patients operated via the subfrontal approach either prior to or after the procedure, which suggests that surgical treatment of tuberculum sellae meningiomas has no effect on pituitary endocrine function.

Microsurgical treatment of tuberculum sellae meningiomas

Objective To explore microsurgical treatment of tuberculum sellae meningiomas.Methods A retrospective analysis was made on 35 cases of tuberculum sellae meningiomas operated from January 2005 to July 2013 in neurosurgery department of Sun Yat-sen Memorial Hospital,surgical approach,removal rate,surgical effect and complications were analysed.Results All patients were accepted microsurgical treatment,twenty cases were operated via subfrontal approach,four cases via anterior interhemispheric approach,ten cases via pterional approach,one case via combined subfrontal and pterional approach.According to Simpson grade,grade Ⅱ,rection was achieved in 26 cases,grade Ⅲ in 4 cases and grade Ⅳ in 5 cases.The total rection rate was 85.7％.There were 28 cases with merger ision loss and visual field defects preoperate,twenty cases were improved after operation,five cases with no change,three cases aggravated.The visual improved rate was achieved 71.4％,there was no surgical mortality case.Conclusion The surround tissue of tuberculum sellae meningiomas is very import ant,microsurgical rection is the main treatment.The choice of surgical approach should according to tumor size,growth pattern,degree of impaired vision and surgeon experience.Family with microanatomy and skillfull microsurgical techique can make sure operation succes. Key words: Meningiomas ; Tuberculum sellae ; Microsurgical operation

Tuberculum sellae meningiomas: surgical considerations

We report our experience on the treatment of tuberculum sellae meningiomas (TSMs) regarding the involvement of the optic canal and clinical outcomes. We reviewed 23 patients who were operated on between January 1997 and December 2008. The surgical approach was unilateral subfrontal supraorbital osteotomy in one piece. Attempts were made to improve visual function via extra/intradural unroofing of the optic canal, which released the optic nerve. Visual symptoms were present preoperatively in 21 patients, and two patients were asymptomatic. Visual acuity remained intact in 6 patients, improved in 10, was unchanged in 5 patients, and worsened in 2 patients. The postoperative visual field was normal or improved in 17 patients, unchanged in four patients, and worsened in two patients. The optic canal and clinoid were drilled extradurally in eight patients and intradurally in nine patients. Total resection of TSMs was achieved in 19 patients. Incomplete resection occurred in two patients. Decompression of the optic canal seemed to increase the visual outcome.

Fronto-basal interhemispheric approach for tuberculum sellae meningiomas; long-term visual outcome

We report our experience with the treatment of tuberculum sellae meningiomas using the fronto-basal interhemispheric approach. A retrospective analysis was performed on a series of 24 patients with tuberculum sellae meningiomas who were operated between March 2000 and January 2007. Patients' presenting symptoms, radiological images, operative reports, and clinical follow-up data were reviewed with special consideration for visual outcome. Visual deterioration was the presenting symptom in all patients, followed by headache in 9 patients (37.5%). The average duration of visual symptoms was 17.6 months. The average tumor diameter was 2.63 cm; encasement of the carotid artery was identified in 7 patients (29%). Complete tumor removal was achieved in 21 patients (87.5%). Mean follow-up period was 52 months. Vision improved in 19 patients (79%), remained stable in 4 (17%) and deteriorated in 1 patient (4%). The degree of tumor removal or visual outcome were both unrelated to the tumor size (p = 0.2 and p = 0.6 respectively). While the degree of preoperative visual deficit did not affect the visual improvement rate in the whole group (p = 0.9), those patients with improvement to good functional vision (>20/40) after the surgery, had a less severe preoperative deficit (p < 0.001). The most common complication was anosmia (29.1%) and there was no mortality. The frontobasal interhemispheric approach is safe and provides a direct anatomical approach to tuberculum sellae meningiomas with relatively low incidence of complications. Patients with improved vision to good functional level had a better preoperative visual status.

EXTENDED ENDOSCOPIC TRANSSPHENOIDAL APPROACH FOR TUBERCULUM SELLAE MENINGIOMAS

Tuberculum sellae meningiomas are classically removed through several different surgical transcranial approaches, including the pterional transsylvian route. Recently, the indications for the transsphenoidal technique, traditionally proposed only for the treatment of intrasellar lesions, have been extended to include lesions located in the supra- and parasellar areas and, among them, tuberculum sellae meningiomas. We describe the surgical technique for the purely endoscopic endonasal variant of the extended transsphenoidal "low route" to tuberculum sellae meningiomas. Over a 22-month period, six patients (three men and three women; mean age, 56.1 yr; age range, 44-70 yr) underwent an extended endoscopic transsphenoidal approach for the treatment of tuberculum sellae meningiomas. Two lesions were less than 2 cm and four were between 2 and 4 cm in size. The details of the surgical technique have been described. Gross total removal of the lesion, without the need for brain retraction and with minimal neurovascular manipulation, was achieved in five patients (83.3%), whereas in one patient, only subtotal removal was possible (>90%) because the mass extended into the right optic canal. Four patients with preoperative visual function defects had complete recovery, whereas two patients experienced a temporary worsening of vision. Both of these patients fully recovered within a few days. One patient had a postoperative cerebrospinal fluid leak that required three operations for cranial base defect repair. This patient showed rapid and unexpected worsening with respect to level of consciousness and anisocoria. An intraventricular hemorrhage was discovered, and the patient died 6 days later. Another patient developed new permanent diabetes insipidus that required hormonal replacement therapy. In experienced hands and in carefully selected patients, the extended endoscopic transsphenoidal approach may constitute a viable alternative to transcranial approaches for tuberculum sellae meningioma. At present, the major limits of the approach include the lack of a reliable technique for the reconstruction of a cranial base defect and inadequate follow-up.

EXTENDED ENDOSCOPIC TRANSSPHENOIDAL APPROACH FOR TUBERCULUM SELLAE MENINGIOMAS

Tuberculum sellae meningiomas are classically removed through several different surgical transcranial approaches, including the pterional transsylvian route. Recently, the indications for the transsphenoidal technique, traditionally proposed only for the treatment of intrasellar lesions, have been extended to include lesions located in the supra- and parasellar areas and, among them, tuberculum sellae meningiomas. We describe the surgical technique for the purely endoscopic endonasal variant of the extended transsphenoidal "low route" to tuberculum sellae meningiomas. Over a 22-month period, six patients (three men and three women; mean age, 56.1 yr; age range, 44-70 yr) underwent an extended endoscopic transsphenoidal approach for the treatment of tuberculum sellae meningiomas. Two lesions were less than 2 cm and four were between 2 and 4 cm in size. The details of the surgical technique have been described. Gross total removal of the lesion, without the need for brain retraction and with minimal neurovascular manipulation, was achieved in five patients (83.3%), whereas in one patient, only subtotal removal was possible (>90%) because the mass extended into the right optic canal. Four patients with preoperative visual function defects had complete recovery, whereas two patients experienced a temporary worsening of vision. Both of these patients fully recovered within a few days. One patient had a postoperative cerebrospinal fluid leak that required three operations for cranial base defect repair. This patient showed rapid and unexpected worsening with respect to level of consciousness and anisocoria. An intraventricular hemorrhage was discovered, and the patient died 6 days later. Another patient developed new permanent diabetes insipidus that required hormonal replacement therapy. In experienced hands and in carefully selected patients, the extended endoscopic transsphenoidal approach may constitute a viable alternative to transcranial approaches for tuberculum sellae meningioma. At present, the major limits of the approach include the lack of a reliable technique for the reconstruction of a cranial base defect and inadequate follow-up.

Postoperative improvement in visual function in patients with tuberculum sellae meningiomas: results of the extended transsphenoidal and transcranial approaches

Recently, extended transsphenoidal surgery (ETSS) has become an alternative to transcranial surgery (TCS) for suprasellar meningiomas, although the relative benefits of ETSS have yet to be established. To evaluate the effectiveness of ETSS, the authors analyzed surgical outcomes of TCS and ETSS. During a 12-year period, 28 patients with meningiomas arising from the tuberculum sellae underwent tumor removal at Kinki University Hospital. The first 12 patients underwent TCS, and the remaining 16 underwent ETSS. In the TCS group, the optic canal on the approach side was unroofed in all cases. In the ETSS group bilateral optic canals were opened, and the dural and bone defects of the skull base were repaired using abdominal fascia and hydroxyapatite cement. In half of the cases, lumbar drainage of cerebrospinal fluid (CSF) was also performed. In a retrospective analysis of this consecutive series of patients, improvement in visual acuity and intraoperative blood loss were significantly better in the ETSS group (p = 0.010 and p = 0.011, respectively), whereas improvement in visual field defects, operative times, and the tumor removal rate were not significantly different between the two groups. Nonvisual surgical complications such as CSF leakage (one patient) and infarction of a perforating artery (three patients) were observed in the TCS group. In the ETSS group, CSF leakage (two patients), anosmia (two patients), and infarction of a perforating artery (two patients) were observed. Given the encouraging results in improvement in visual acuity, ETSS may be acceptable for the treatment of tuberculum sellae meningiomas.

Microsurgical Treatment of Tuberculum Sellae Meningiomas

Microsurgical Treatment of Tuberculum Sellae Meningiomas

TUBERCULUM SELLAE MENINGIOMAS

Tuberculum sellae meningiomas present a special challenge because of their proximity to arteries of the anterior circulation, anterior visual pathways, and the hypothalamus. The authors report on the clinical outcome after surgical treatment of tuberculum sellae meningiomas in our neurosurgical department. A retrospective study was conducted analyzing the charts of the patients, including surgical records, discharge letters, histological records, follow-up records, and imaging studies. Patients with associated neurofibromatosis Type 2 were excluded from the study. One thousand eight hundred meningiomas were operated on between 1978 and 2002. Seventy-two of these patients had tuberculum sellae meningiomas; four had undergone previous surgical procedures in outside hospitals. Fifty-five patients were women; 17 were men. Their mean age was 54.3 years (range, 30-86 yr). All patients had visual disturbances at presentation. Tumors were operated through the bifrontal approach (n = 21, from 1978 through 1995), the pterional/frontotemporal approach (n = 21, from 1982 through 2002), and the frontolateral approach (n = 30, from 1984 through 2002). Total tumor removal was achieved in most patients (Simpson 1 + 2, 91.7%). The perioperative mortality rate was 2.8% (two out of 72 patients). Immediate postoperative improvement of visual disturbance was observed in 65% of patients. Visual improvement was dependent on the duration of preoperative visual symptoms, but not on preoperative visual acuity or tumor size. The visual improvement rate was significantly better in patients who underwent frontolateral tumor resection (77.8%) compared with those who underwent bifrontal craniotomy (46.2%). The overall recurrence rate was 2.8% (two out of 72 patients). The mean follow-up time for all patients was 4 to 238 months (mean, 45.3 mo [3.8 yr]). From 1978 through 2002, tuberculum sellae meningiomas were removed microsurgically using three different surgical approaches. Considering the operative morbidity and mortality, the frontolateral and pterional approach provided remarkable improvement compared with the bifrontal approach. These approaches allowed quick access to the tumor and were minimally invasive with less brain exposure, but still engendered high rates of total tumor removal. By comparison, the frontolateral approach provided the best results concerning visual outcome while representing the least invasive surgical approach.

1.鞍結節髄膜腫の手術(MS-9 頭蓋底髄膜腫の手術,モーニングセミナー,第26回 日本脳神経外科コングレス総会)

1.鞍結節髄膜腫の手術(MS-9 頭蓋底髄膜腫の手術,モーニングセミナー,第26回 日本脳神経外科コングレス総会)

Treatment of tuberculum sellae meningiomas:a long-term follow-up study

Surgical techniques and their results for tuberculum sellae meningiomas were studied. Thirty-three cases, the first of which was operated in 1980, were analysed. There were 4 men and 29 women with an average age of 46.7 years. Eight cases underwent reop erations. The mean follow-up was 10.7 years. Approaches were pterional for 15 patients, FOZ/FO for 10, bilateral subfrontal for 6, and others for 2. Simpson's grade (I, II, III, IV) were 12, 9, 0, and 12 cases respectively. Recurrence rate was 0% for gra de I and 58.3% for grade IV. The FOZ/FO approach resulted in a lower Simpson's grade (P=0.05), but other factors were not related to Simpson's grade (P=0.05). The postoperative visual outcome did not depend on total (grade I and II) or subtotal (grade III and IV) removal (P=0.01). We conclude that radical removal of the tumours may result in lower recurrence rate without increasing surgical complications. Furthermore, skull base approaches can improve the rate of radical removal of tuberculum sellae meningiomas.

鞍結節部髄膜腫の手術 : 視神経管入口部開放の重要性について

われわれは鞍結節部髄膜腫における視神経管入口部への腫瘍の進展につき検討を行った.対象は鞍結節部髄膜腫5例で, MRIにおける視神経管入口部への腫瘍の進展と術中の同部位への腫瘍の進展の有無を検討した.全例pterional approachにて手術を行った.その結果, MRI所見と術中所見の対比が可能であった3例では, MRIのT2強調像の冠状断が視神経管入口部への腫瘍と進展について, 術中所見とよく相関した.よって鞍結節部髄膜腫の手術においては, 術前のMRIのT2強調像の冠状断が腫瘍の進展の診断に有用であり, 術中, 両側の視神経管入口部を開放して, 腫瘍の進展の有無を確認することが重要と思われた.