Treatment Of Pellagra Research Articles

Evaluation of the Isotopic Abundance Ratio of Consciousness Energy Healing Treated L-Tryptophan Using LC-MS Spectrometry

L-tryptophan is an essential α-amino acid, necessary for the normal growth in newborns, nitrogen balance in adults, protein synthesis, precursor of serotonin, melatonin, niacin, and albeit inefficiently in human, also the precursor of indole alkaloids and auxins in plants. This current study was designed to investigate the impact of the Trivedi Effect®-Biofield Energy Healing Treatment (Blessing) on the structural properties and the isotopic abundance ratio of L-tryptophan using LC-MS analytical technique. L-tryptophan sample was divided into two parts, one part of L-tryptophan was considered as the control sample (no Biofield Energy Treatment was provided), while the second part was treated with the Trivedi Effect®-Consciousness Energy Healing Treatment/Blessing remotely by a renowned Biofield Energy Healer, Dahryn Trivedi and termed as the treated sample. The mass spectra of both the control and treated samples with respect to the chromatographic peak at retention time (Rt) 2.1 minutes exhibited the mass of the molecular ion peak adduct with hydrogen ion at m/z 205.08 (calcd for C11H13N2O2+, 205.1), along with low molecular fragmented mass peaks at m/z 188, 159, and 102 for C11H12N2O2+, C10H11N2+, and C8H6+, respectively were also observed. The isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 15N/14Nor17O/16O) in the treated L-tryptophan was significantly increased by 35.93% compared with the control sample. Hence,the 13C, 2H, 15N, and 17O contributions from C11H13N2O2+ to m/z 206.08 in the treated L-tryptophan was significantly increased compared to the control sample. It could be hypothesized that the changes in the isotopic abundance and mass peak intensities due to the modification in nuclei possibly through the interference of neutrino particles using the Trivedi Effect®-Consciousness Energy Healing Treatment. The Biofield Energy Treated/Blessed L-tryptophan with increased stable isotopic abundance ratio might have changed the physicochemical properties with higher force constant in the molecule. The new form of treated L-tryptophan would be a better and more stable in the supplements, nutraceutical, and pharmaceutical formulations, which would be advantageous for the prevention and treatment of pellagra, depression, kynurenine. It could also maintain the normal label of tryptophan and avoid increase of its metabolite, lower the neurotoxin and a metabotoxin behavior, glutaric aciduria type I (glutaric acidemia type I) disorder, eosinophilia-myalgia syndrome (EMS), incurable and sometimes fatal flu-like neurological condition, etc. As tryptophan is the precursor for the plant hormones like indole alkaloids and auxins, hence, this treated L-tryptophan would be advantageous for the improvement of yield, productivity, and quality of crops and other plants.

The use of Neurobion Forte in the Treatment of Pellagra in an adult on anti-TB treatment: A case report from Lusaka, Zambia

The deficiency of Niacin and/or its precursor amino acid, Tryptophan can result in a disease called Pellagra. Isoniazid (INH), a key drug used in tuberculosis (TB) treatment has been associated with pellagra particularly in developing nations where poor nutritional status is highly prevalent among its people.We report a case of pellagra with classical dermatological manifestations (hyperpigmented skin lesions around the neck), on the face, and external surfaces of the upper limbs) in a black African HIV negative adult female, on TB treatment for 11 weeks managed with a combo of Vitamin B1 - 10mg, Vitamin B2 - 10mg, Vitamin B3 - 45mg, Vitamin B5 - 50mg, Vitamin B6 - 3mg and ® Vitamin B12 - 15mcg (Neurobion Forte) with noticeable response to the treatment within one week.

The use of Neurobion® Forte in the Treatment of Pellagra in an adult on anti-TB treatment: A case report from Lusaka, Zambia

Abstract
 The deficiency of Niacin and/or its precursor amino acid, Tryptophan can result in a disease called Pellagra. Isoniazid (INH), a key drug used in tuberculosis (TB) treatment has been associated with pellagra particularly in developing nations where poor nutritional status is highly prevalent among its people.We report a case of pellagra with classical dermatological manifestations (hyperpigmented skin lesions around the neck), on the face, and external surfaces of the upper limbs) in a black African HIV negative adult female, on TB treatment for 11 weeks managed with a combo of Vitamin B1 - 10mg, Vitamin B2 - 10mg, Vitamin B3 - 45mg, Vitamin B5 - 50mg, Vitamin B6 - 3mg and Vitamin B12 - 15mcg (Neurobion® Forte) with noticeable response to the treatment within one week.

Two Multivariate Calibration Models for Assay of Niacin in Complex Mixtures with Its Official Impurities: A Pharmaceutical Application.

Niacin (NIA) is a water-soluble vitamin and the primary treatment of pellagra. No analytical method was found to assess NIA in complex mixtures with its official impurities. Two validated, accurate, and selective chemometric models were developed to assay NIA in the presence of its four official impurities, including pyridine, a nephrotoxic and hepatotoxic substance. Additionally, the two selective chemometric models were compared by processing UV spectra in the range 220-305 nm and applying partial least squares regression (PLSR) and support vector regression (SVR) models. A five levels five factors experimental design was chosen to exhibit a training set of 25 mixtures that had numerous variable percentages of tested substances. A test set consisting of 10 mixtures was designed to confirm the predictive power of the suggested models. The presented results substantiate the strength of the developed multivariate calibration models to assay NIA specifically with high selectivity and accuracy (100.02 ± 1.312 and 100.04 ± 1.272 for PLSR and SVR models, respectively). The root mean square error of prediction for the validation set mixtures was applied as a main comparison tool and it was found to be 0.2016 and 0.1890 for PLSR and SVR models, respectively. The results of the developed models and the reported HPLC method were statistically compared, where F-values and Student's t-tests did not show significant difference in regards to accuracy and precision. The SVR model proved to be more accurate than the PLSR model, producing a high generalization capacity, while PLSR was easy to implement and fast.

Asylum Doctor: James Woods Babcock and the Red Plague of Pellagraby Charles S. Bryan, M.D. Columbia, S.C., University of South Carolina Press, 2014, 376 pp., $34.95.

Asylum Doctor: James Woods Babcock and the Red Plague of Pellagraby Charles S. Bryan, M.D. Columbia, S.C., University of South Carolina Press, 2014, 376 pp., $34.95.

Neuropsychiatric Symptoms in an Early Description of Pellagra

Back to table of contents Previous article Next article LETTERFull AccessNeuropsychiatric Symptoms in an Early Description of PellagraAndrea Eugenio Cavanna M.D., Ph.D.,Adrian C. Williams M.D., F.R.C.P.,Andrea Eugenio Cavanna M.D., Ph.D.Search for more papers by this author,Adrian C. Williams M.D., F.R.C.P.Search for more papers by this author,Published Online:1 Oct 2010https://doi.org/10.1176/jnp.2010.22.4.451.e39AboutSectionsView articleView PDFView EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleTo the Editor: Pellagra, a largely forgotten condition in Western economies, is a complex systemic disease caused by inadequate dietary intake of coenzyme precursors nicotinamide and tryptophan, whose main natural sources are meat. Pellagra was first described in the medical literature in 1735 by Spanish physician Gaspar Casal, who highlighted its relationship with poverty and dietary restrictions in rural populations. 1 Classical nosological descriptions have dictated that the clinical picture of pellagra is characterized by the three “Ds” of dermatitis, diarrhea, and dementia, which, if untreated, invariably lead to the fourth D (i.e., death). The clinical hallmark of pellagra has long been identified with the characteristic dermatitis on sun-exposed skin (butterfly rash or “Casal’s necklace”) which earned the condition the lay name of “the sour skin” disease. Apart from dementia with subcortical features (cognitive slowness in addition to memory problems), neuropsychiatric symptoms have traditionally received little attention in modern pellagra literature. We hereby provide evidence that these symptoms were in fact central to early descriptions of pellagra. Italian physician Gaetano Strambio (1752–1831) was appointed by Emperor Joseph II of the Hapsburgs as head of the pellagra hospital in Legnano (Milan) in 1874, and he devoted his professional life to the study and treatment of pellagra, an endemic disease in peasant populations based in Northern Italy across the 18th and 19th centuries. Strambio wrote some of the earliest treatises on pellagra based on his experience with large cohorts of patients. In his Observations in the Royal Hospital for Pellagra 1784–1785 , 2 he combined outstanding clinical acumen with remarkable scientific attitudes to provide accurate descriptions of 77 case histories ( historiae ). These Observations have never been translated from Latin and provide interesting demographic and clinical data on 77 pellagrins (36 males) with a focus on otherwise neglected neurological and psychiatric manifestations. In Strambio’s cohort, 13 patients exhibited muscular spasms, contractures and/or convulsions, four developed tremor, and two became bulimic. Of note, Strambio reported peculiar gait abnormalities ( festinatio ) in six patients and commented on the original description of scelotyrbe festinans (“running disturbance of the limbs”) in pellagrins made by Sauvages in 1763 3 : Quod bis vidit Sauvagesius, saepe in pellagrosis observavi; aegri scilicet aliquando corpore anterius inclinato currere coguntur, donec vel aliquid offendant, cui adhaereant, vel humi concidant, nisi ab adstantibus sustineantur. [What Sauvages saw in two cases, I often observed in pellagrins; namely, patients at times are forced to run with the body bent forward, until they either lean onto obstacles or fall to the ground, unless grabbed by other people.] 2 Both Sauvages’ and Strambio’s observations document that festinatio was consistently described in pellagrins decades before James Parkinson’s essay, while other parkinsonian features in pellagra were later reported by Paravicini. 4 It has recently been suggested that cases of pellagra associated with alcohol abuse and HIV infection may be on the surge in both developing countries and in underprivileged segments of Western society. 5 Physicians should be aware of the wide spectrum of neuropsychiatric presentations for the early diagnosis and appropriate management of this treatable condition. Department of Neuropsychiatry, BSMHFT and University of Birmingham, UK; Sobell Department of Movement Disorders, Institute of Neurology, University College London, UKDepartment of Neurology, UHB and University of Birmingham, UK

Opaque-2 maize in the prevention and treatment of pellagra

In order to determine the usefulness of opaque-2 maize in the prevention of pellagra, people from the third and fifth brigades of a commune in a maize-eating district of Northwest China received opaque-2 maize in their diet and served as the experimental subjects. People from the neighboring sixth brigade ate conventional maize and served as the control subjects. After three months there were no cases of pellagra in the experimental groups, but there were three cases in the control group; the incidence was 1.8%. Prior to the study, urinary excretion values of N-methylniacinamide (N-MN) of the subjects were measured. There were no significant differences among the three brigades (P>0.05). By the conclusion of the study the differences in urinary excretion of N-MN between the experimental and control groups were highly significant: 0.21±0.02 and 0.21±0.02 mg/2 h for the experimental groups and 0.12±0.01 mg/2 h for the control group. Opaque-2 maize also was used in a study of the treatment of pellagra. Persons with pellagra were divided into three groups: Group 1 received opaque-2 maize, Group 2 received conventional maize plus niacinamide (10 mg per day), and Group 3 received conventional maize. Before treatment, the average values of the urinary excretion of N-MN of each group were not significantly different. After one month of the treatment, a loading dose of 50 mg niacinamide was administered orally. Four-hour urines were collected and analyzed for N-MN. The differences between Group 1 and Group 3 or Group 2 and Group 3 were significant. Although the results showed that opaque-2 maize could be used in the prevention and treatment of pellagra, meat, milk, and milk products should be recommended to people in all of the areas where pellagra is endemic. The planting of opaque-2 maize, however, should provide an effective means to supply utilizable niacin and is a simple, economical way to prevent pellagra for the present.

Arsphenamine in the Treatment of Pellagra

Arsphenamine in the Treatment of Pellagra

ANAPHYLAXIS TO THE INJECTION OF NICOTINIC ACID (NIACIN); SUCCESSFUL TREATMENT WITH EPINEPHRINE

Case Reports1 February 1947ANAPHYLAXIS TO THE INJECTION OF NICOTINIC ACID (NIACIN); SUCCESSFUL TREATMENT WITH EPINEPHRINELOUIS PELNER, M.D.LOUIS PELNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-290 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn anaphylactic reaction to nicotinic acid has not been previously reported in the literature, although sensitivity to the drug has been noted before. The present widespread use of nicotinic acid, both as a vitamin and as a drug, makesreports of these accidents mandatory, because they will undoubtedly be experienced by others. The morbidity can probably be avoided by a careful questioning of the patient before the injection of nicotinic acid is given. In our cases, the usual treatment for anaphylactic shock was sufficient to overcome the symptoms in these patients.Rachmilewitz and Glueck1described the occurrence of an urticarial dermatitis...Bibliography1. RACHMILEWITZGLUECK MHI: Treatment of pellagra with nicotinic acid, Brit. Med. Jr., 1938, ii, 346. CrossrefGoogle Scholar2. CHENROSEROBBINS KKCLEB: Toxicity of nicotinic acid, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 241. CrossrefGoogle Scholar3. WATROUS RM Dermatitis from industrial contact with nicotinic acid, Jr. Am. Med. Assoc., 1939, cxii, 2132. CrossrefGoogle Scholar4. VAUGHAN WT: Practice of allergy, 1939, C. V. Mosby, St. Louis, p. 811. Google Scholar5. LAWS C: Sensitization to thiamin chloride, Jr. Am. Med. Assoc., 1941, cxvi, 176. SCHIFF, L.: Collapse following parenteral administration of a solution of thiamin hydrochloride, Jr. Am. Med. Assoc., 1941, c, 669. JOLLIFFE, N.: Treatment of neuropsychiatric disorders with vitamins, Jr. Am. Med. Assoc., 1941, cxvii, 1496. STERN, W. MORGENSTERN M.: Sensitization to thiamin hydrochloride. Report of another case, Ann. Int. Med., 1944, xx, 826. MISTRANI M. A.: Vitamin B, hypersensitivity with desensitization; report of a case, Jr. Allergy, 1944, xv, 150. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication August 17, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitaminsLARYNGEAL SPASMREACTIONS AFTER VITAMIN-B INJECTIONToxic Labyrinthitis Following Oral Undecylenic Acid Treatment of PsoriasisVitamin Supplementation in Health and Disease 1 February 1947Volume 26, Issue 2Page: 290-294KeywordsAnaphylaxisDrugsEpinephrineMorbidityNiacinShock ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...

THE DIETARY FACTOR IN THE ETIOLOGY OF PERNICIOUS ANEMIA

Excerpt Addisonian pernicious anemia is known to develop in accordance with genetic, racial, climatic and geographic determinants. The hypothesis that the disease is of dietary origin has been adva...

THE SYNDROME OF MULTIPLE VITAMIN DEFICIENCY

Excerpt Good nutrition depends not only on the intake of sufficient amounts of all the substances required for normal metabolic processes but also on their adequate absorption, storage and utilizat...

THE ETIOLOGY OF PELLAGRA

During the past three or four years great strides have been made in the investigation of the cause and treatment of pellagra. This apparently sudden advance however is the result of the work of many men who have been moving painstakingly toward the goal. Pellagra, from the Italian words “pelle agra” (rough skin) is characterized in its classic form by mental disturbance, various skin lesions and intestinal inflammation. The disease has existed for centuries, and descriptions by early writers indicate that it probably was confused with leprosy and with mental and intestinal disorders due to other causes. It was first recognized as a definite syndrome in the eighteenth century when it was prevalent in central Europe. Since the early part of the present century there has been a wide incidence of the disease in the southern United States, but it has also been observed in many lands. Furthermore it is now becoming evident that subclinical or mild cases simulating the picture of psychoneurosis are quite widespread. Early workers in this field advanced various theories to account for the condition. One of the most widely accepted of these attributed the cause to maize or Indian corn. As corn was the exclusive diet in districts of endemic pellagra in Italy in the nineteenth century it was felt that the corn itself in some way caused the disease. In 1826 Sette suggested that a fungus acting on the oil of the grain produced a poison. Lombroso in 1872 also attributed the cause to a toxin. He concluded, “in pellagra we are dealing with an intoxication produced by poisons developed in spoiled corn through the action of certain micro-organisms in themselves harmless to man.” Ceni, in 1902, said the disease was due to certam moulds on the grain. At the turn of the century pellagra became very widespread in the southern States, where the people depended on the products of their cornfields rather than on expen-

Nicotinic Acid in the Treatment of Pellagra: Case Report

Typical pictures of Vitamin deficiency are rarely encountered in the wards of this hospital. Frequently, the possibility of avitaminoses are considered in our provisional diagnoses and in these instances vitamin therapy often constitutes part of the treatment. We share the opinions of many that varying degrees of avitaminosis do exist and that classical pictures are rare. It has become rather generally recognized that there are unknown factors present which might explain why certain individuals develop vitamin deficiency diseases while other individuals do not, though both have lived under similar conditions. Among the most interesting of this group are the alcoholics who develop a pellagra like syndrome. An inadequate dietary regimen is believed to be the most important factor in the production of such a syndrome. Exposure to actinic rays plays a large part in the causation of the dermatitis. Undoubtedly, this in turn is related to some disturbance in porphyrin metabolism. The efficacy of nicotinic acid in treating these patients has been stressed. The following case is reported because of the encouraging and rapid results secured with this therapeutic agent.

A REACTION TO THE ORAL ADMINISTRATION OF NICOTINIC ACID

Amost all the reports on the treatment of pellagra with nicotinic acid refer to unpleasant, but harmless, reactions. Fouts, Helmer, Lepkovsky and Jukes 1 treated three cases of pellagra with 500 mg. and one case with 1 Gm. of nicotinic acid. A sensation of heat and tingling on the skin was noted in all four cases. These sensations appeared within ten minutes, lasted from ten to twenty minutes, and were accompanied by dilatation of the peripheral blood vessels and slight, temporary fall in blood pressure. The Smiths and Ruffin 2 observed a marked flushing of the face, neck, chest and arms a few minutes after intramuscular injection of 60 mg. of nicotinic acid, which lasted for fifteen minutes. A similar reaction followed the intravenous administration of approximately 12 mg. They note that the pulse, respiration and blood pressure were not affected and that there was no discomfort except for a

NICOTINIC ACID IN THE TREATMENT OF PELLAGRA

Medical Journal of AustraliaVolume 2, Issue 20 p. 830-831 Current Comment NICOTINIC ACID IN THE TREATMENT OF PELLAGRA First published: 01 November 1938 https://doi.org/10.5694/j.1326-5377.1938.tb45808.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume2, Issue20November 1938Pages 830-831 RelatedInformation

PELLAGRA AND NICOTINIC ACID

During the early period of investigation of vitamins Funk demonstrated that nicotinic acid is a constituent of the vitamin B complex. At a later date Elvehjem and his collaborators¹in their search for the antipellagra factor isolated nicotinic acid from highly active concentrates and found that a commercial preparation of this compound was highly effective in curing canine blacktongue. By analogy it was suggested that clinical trials should determine whether nicotinic acid would be equally effective against human pellagra.²More or less recently Spies and Smith and their colleagues, and others³as well, have demonstrated convincingly the highly effective role of nicotinic acid in the treatment of pellagra. In this section of the United States, where pellagra has often assumed the proportions of a major medical and psychiatric problem, the reports of their work and the results of local experiments produce the impression that a conspicuous advance

Treatment of Pellagra with Nicotinic Acid

Treatment of Pellagra with Nicotinic Acid

NICOTINIC ACID IN THE TREATMENT OF PELLAGRA

In recent months there have been quite a few references in the medical literature to the use of nicotinic acid (3: pyridine carboxylic acid) in the treatment of pellagra.¹ Only one of these reports has stressed the fact that the patient had dementia, and it was mentioned as a mild dementia and was present only at intervals.^1b For that reason, it is believed that the report of a case recently observed, in which the patient is still under treatment, will be of interest. Also a comparison may be drawn between the effectiveness of the parenteral and the oral administration of nicotinic acid for pellagrous dementia, as in the case reported here the acid was administered only by the oral route, while in the one previously reported it was administered mostly by the parenteral route. <h3>REPORT OF CASE</h3> Mrs. M. G., aged 59, white, was first seen March 20,

ADVANCES IN THE TREATMENT OF PELLAGRA

Editorial1 March 1938ADVANCES IN THE TREATMENT OF PELLAGRAP. C.P. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-9-1760 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe success of Goldberger and his associates in experimentally producing pellagra in man and its counterpart, black tongue, in dogs proved that a dietary deficiency plays an essential part in the production of these diseases. His demonstration that yeast, liver, and other foods rich in vitamin B2 (G) prevents and usually cures the disease indicates that the active substance is probably to be found in some portion of the vitamin B2 complex.Certain facts, however, have led some investigators to believe that other factors are also concerned in the development of the disease. It seems probable that some individual predisposition...1 RUFFINSMITH JMDT: A clinical evaluation of the potency of various extracts of liver in the treatment of pellagra, South. Med. Jr., 1937, xxx, 4-14. CrossrefGoogle Scholar2 SYDENSTRICKERTHOMAS VPJW: Some factors in the etiology of pellagra, South. Med. Jr., 1937, xxx, 14-18. CrossrefGoogle Scholar3 SMITHRUFFIN DTJM: Effect of sunlight on clinical manifestations of pellagra, Arch. Int. Med., 1937, lix, 631-645. CrossrefGoogle Scholar4 SPIESCHINNMCLESTER TDAJB: Treatment of endemic pellagra, South. Med. Jr., 1937, xxx, 18-21. CrossrefGoogle Scholar5 JUKESLEPKOVSKY THS: Distribution of "filtrate factor" (water soluble vitamin belonging to vitamin B complex and preventing dietary dermatitis in chicks) in certain feedingstuffs, Jr. Biol. Chem., 1936, cxiv, 117-121. CrossrefGoogle Scholar6 ELVEHJEMMADDENSTRONGWOOLEY CARJFMDW: Relation of nicotinic acid and nicotinic acid amide to canine black tongue, Jr. Am. Chem. Soc., 1937, lix, 1767. CrossrefGoogle Scholar7 SPIESCOOPERBLANKENHORN TDCMA: Central Society for Clinical Research, Chicago, Nov. 5, 1937. Google Scholar8 SPIESCOOPERBLANKENHORN TDCMA: Nicotinic acid in the treatment of pellagra, Jr. Am. Med. Assoc., 1938, cx, 622-627. CrossrefGoogle Scholar9 SMITHRUFFINSMITH DTJMSG: Pellagra successfully treated with nicotinic acid: a case report, Jr. Am. Med. Assoc., 1937, cix, 2054-2055. CrossrefGoogle Scholar10 FOUTSHELMERLEPKOVSKYJUKES FJOMSTH: Treatment of human pellagra with nicotinic acid, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 405. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1938Volume 11, Issue 9Page: 1760-1762KeywordsFoodLiverLiver diseasesTongue ePublished: 1 December 2008 Issue Published: 1 March 1938 PDF downloadLoading ...

AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT

Article1 November 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTMOTOR INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM IN PELLAGRA; A REPORT OF 2 CASES*M. A. BLANKENHORN, M.D.M. A. BLANKENHORN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-5-823 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNervous and mental symptoms are conspicuous in textbook descriptions of pellagra, but only the more extensive studies describe motor disturbances other than peripheral neuritis. Hemiplegias and paraplegias are described as being rare and generally occurring in the severe and terminal stages. Grinker1 in a recent textbook states briefly that a picture similar to the neurological complications of pernicious anemia may appear but are never as severe or progressive. He states further that the lesions of the nervous system in pellagra are "not irreversible."With newer methods of treatment, especially with new forms of diet and vitamin concentrates, the severe and...Bibliography1. GRINKER RR: Neurology, 1934, Charles C. Thomas, Springfield, Illinois. Google Scholar2. SPIES TD: The treatment of pellagra, Jr. Am. Med. Assoc., 1935, civ, 1377. CrossrefGoogle Scholar3. KLAUDERWINKELMAN JVNW: Pellagra among chronic alcoholic addicts; a clinical and laboratory study, Jr. Am. Med. Assoc., 1928, xc, 364. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Read in part at the Ninth Annual Meeting of the Central Society for Clinical Research, Chicago, Illinois, November 6, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1937Volume 11, Issue 5Page: 823-826KeywordsDietLesionsNervous systemParaplegiaPernicious anemia Issue Published: 1 November 1937 PDF downloadLoading ...