Treatment Of Parasitosis Research Articles

Drug Technology in Hunting Practice

Abstract Antiparasitic therapy in living ratites is based on the right dose and efficacy is only when the drug is pharmaceutically stable and safe. Ivermectin is considered to be the most widely used drug in the treatment of parasitosis in ruminants worlwide. For these reasons, in our study, we focused on the pharmaceutical investigation of ivermectin by SEM analysis of its powder particle shape and size, flow properties of solids (angle of repose, compressibility index, Hausner ratio) and zeta potential.

Development and implementation of scientifically based technology of treatment of parasitoses of horses herd keeping in conditions of Yakutia

The article presents the regularities of the epizootic process of parasitosis of horses with herd content of horses in Yakutia. In the long process of tebenevka reduction of fatness of horses can lead to the disruption of their normal functioning, deteriorates the ability of tebenevka, reduced immunity, observed in mares abortion. The authors point out that in the best case, stallions can lose up to 10-12% over the winter, and mares up to 20-22% of the weight gained by them after summer feeding, to prevent the strong impact of cold factors of tebenevka on the body of animals, a scientifically based technology of complex therapy, with the organization of feeding, is recommended. The authors confirm that the factor providing intensive contamination of pastures by eggs and invasive larvae of helminths is the crowded content providing powerful growth of extensiveness and intensity of invasion in all livestock of horses lack of planned preventive and therapeutic deworming.

Effect of probiotics on giardiasis. Where are we?

ABSTRACT Giardiasis, an intestinal infection caused by Giardia lamblia, was recently included in the ‘Neglected Diseases Initiative’ by the World Health Organization. Symptomatic patients can develop mild diarrhea up to a severe malabsorption syndrome, and children may show significantly impaired cognitive and physical development. Currently, nitroimidazoles are the main class of antibiotic used to treat giardiasis. Despite the efficacy of these drugs, adverse effects and reported resistance have increased, encouraging studies to identify and develop therapeutic alternatives. In this context, probiotics may represent an attractive option. Probiotics are defined as live microorganisms that, when administered in suitable amounts, confer a health benefit to the host. The use of probiotics in the treatment of parasitosis has been suggested because of its beneficial effects, such as a reduced time of gastrointestinal symptoms and parasite load in animal models and humans. Probiotics have been studied as an alternative treatment for giardiasis. In this review, we evaluated probiotic effectiveness in the treatment and prevention of this disease. Based on the studies examined herein, we conclude that probiotics have a beneficial effect on the modulation of giardiasis.

ЭФФЕКТИВНОСТЬ ПРОТИВОПАРАЗИТАРНОГО ПРЕПАРАТА ИВЕРПРАДАГ ПРИ ЛЕЧЕНИИ ПАРАЗИТОЗОВ У ЛОШАДЕЙ

The article provides information about the new preparation Iverpradag, developed by the firm "Gudratli lukman" (Turkmenistan), which is being tested in Russian Federation and Turkmenistan, intended for the prevention and treatment of parasitosis in horses. The active principle of the developed preparation is widely known and very effective ivermectin and praziquantel (in complex). Studies conducted in Russia and Turkmenistan showed high effectiveness of the drug against nematodes including Delafondia vulgaris, Alfortia edentatus, Dictyocaulus arnfieldi, Parascaris equorum, Strongylus equinus, Strongyloides westeri, Setaria equina, and cestode, including Anoplocephala magna, Anoplocephala perfoliata and Paranoplocephala mamillana, as well as against gastric larvae (Gastrophilus spp.) parasitizing in horses. The conducted studies showed high efficiency of the drug Iverpradag in the form of paste when applied at the rate of 1 dose (0,9 ml) per 100 kg of body weight.

O uso de plantas medicinais para doenças parasitárias

O uso de plantas para tratamento de muitas enfermidades vem do conhecimento de antepassados e se propaga ao longo dos anos, mostrando ser uma boa alternativa, principalmente para aqueles que possuem poucos recursos financeiros. Dentre as doenças tratadas encontram-se as parasitoses que são a causa de mais de 200 mil mortes por ano. Esta revisão sistemática pesquisou, na literatura, quais espécies vegetais são usadas por diferentes comunidades do mundo para o tratamento de parasitoses. Para isso foram utilizados os bancos de dados primários: PubMed, SciELO e LILACS. Os termos usados na busca encontraram-se na língua inglesa, associados com o operador booleano AND: “parasitic diseases” AND “plants medicinal”. Encontrando-se 853 publicações, sendo posteriormente aplicados critérios de inclusão e exclusão, selecionando ao todo 9 artigos. Foram verificadas 67 espécies de 42 famílias, na qual a família Leguminosae foi a mais citada pela população, e as espécies vegetais mais usadas foram Azadirachta indicam, Euphorbia abyssinica e Mangifera indica, com destaque para a primeira. A malária foi a que teve maior número de plantas medicinais para o seu tratamento. Apesar do desenvolvimento de fármacos, observa-se que a medicina tradicional não caiu em desuso, buscando incentivar estudos científicos que garantam a eficácia terapêutica destas plantas medicinais.

Posterior reversible encephalopathy syndrome in a renal transplanted patient

Patient: Male, 28Final Diagnosis: Posterior reversible encephalopathy syndromeSymptoms: Headache • pain around umblical region • seizures • visual disturbancesMedication: Mycophenolate mofetilClinical Procedure: Treatment of parasitosis • antiepileptic treatment • control of hypertension • changing mycophenolate mofetil to everolimusSpecialty: TransplantologyObjective:Unusual or unexpected effect of treatmentBackground:Posterior reversible encephalopathy syndrome (PRES) is characterized by reversible neurological findings with clinical hallmarks such as headache, confusion, seizures, cortical visual disturbances, and other focal neurological signs.Case Report:A 28-year-old male patient was hospitalized secondary to diarrhea and abdominal pain. He had renal transplantation due to renal amyloidosis secondary to familial Mediterranean fever (FMF). In his clinical follow-up, he had seizures, hemiparesis, blurred vision, and vomited an Ascaris lumbricoides. MRI results led to diagnosis of PRES. Mycophenolate mofetil was changed to everolimus, his systolic blood was pressure kept below 140 mm hg, and his intestinal parasitosis was treated. During follow-up, he had no pain and no diarrhea. His neurological symptoms turned to normal within 48 hours and neuroradiological findings returned to normal within 2 weeks.Conclusions:PRES is a rare disorder of unknown incidence in renal transplantation patients. Early diagnosis is very important to prevent irreversible neurological sequelae. PRES is totally reversible with cessation of the offending agent, rapid control of hypertension, and treatment of the underlying disease. For early diagnosis and to reduce morbidity and mortality, stool sample examination should be made in patients taking immunosuppressive drugs.

Hydroxymethylnitrofurazone:Dimethyl-β-cyclodextrin Inclusion Complex: A Physical–Chemistry Characterization

Hydroxymethylnitrofurazone (NFOH) is active against Trypanosoma cruzi; however, its low solubility and high toxicity precludes its current use in treatment of parasitosis. Cyclodextrin can be used as a drug carrier system, as it is able to form inclusion (host-guest) complexes with a wide variety of organic (guest) molecules. Several reports have shown the interesting use of modified beta-cyclodextrins in pharmaceutical formulation, to improve the bioavailability of drugs and to decrease their toxicity. The aim of this work was to characterize inclusion complexes formed between NFOH and dimethyl-beta-cyclodextrin (DM-beta-CD) by complexation/release kinetics and solubility isotherm experiments using ultraviolet (UV)-visible spectrophotometry and by the measurement of the dynamics information obtained from T(1) relaxation times and diffusion (DOSY) experiments using nuclear magnetic resonance (NMR) spectroscopy. The complex was prepared at different NFOH and DM-beta-CD molar ratios. The UV-visible measurements were recorded in a spectrophotometer, and NMR experiments were recorded at 20 degrees C on a NMR spectrometer (Varian Inova) operating at 500 MHz. Longitudinal relaxation times were obtained by the conventional inversion-recovery method and the DOSY experiments were carried out using the BPPSTE sequence. The kinetics of complexation revealed that 30 h is enough for stabilization of the NFOH absorbance in presence of cyclodextrin. Solubility isotherm studies show a favorable complexation and increase in solubility when NFOH interacts with cyclodextrin. The analysis of the NMR-derived diffusion coefficients and T(1) relaxation times shows that in the presence of DM-beta-CD, NFOH decreases its mobility in solution, indicating that this antichagasic compound interacts with the cyclodextrin cavity. The release kinetics assays showed that NFOH changes its release profile when in the presence of cyclodextrin due to complexation. This study was focused on the physicochemical characterization of drug-delivery formulations that may serve as potentially new therapeutic options for the treatment of Chagas' disease.

5178857 Pharmaceutical compositions and their use in the treatment of parasitoses: Hanns Goeth, Werner Frank, Ingeborg Renner, Biberach, Federal Republic Of Germany assigned to Boehringer Ingelheim International GmbH

5178857 Pharmaceutical compositions and their use in the treatment of parasitoses: Hanns Goeth, Werner Frank, Ingeborg Renner, Biberach, Federal Republic Of Germany assigned to Boehringer Ingelheim International GmbH