Odontogenic myxoma (OM) is an uncommon intraosseous benign neoplasm, locally invasive, that occurs more frequently in young adults on the posterior region of mandible. The recurrence rate ranges from 10% to 30%, especially in conservative approaches. Marginal resection should be considered as the therapeutic choice. The aim of this study was to report the treatment of 2 patients who were submitted to marginal resection due to mandibular OM. Then, reconstruction with iliac crest bone graft was performed with subsequent oral implant–supported rehabilitation. The patients did not present recurrence after 3 years of follow-up. Adequate maxillofacial complex function and esthetics were observed. The treatment of mandibular OM often results in substantial continuity defect. Esthetics, speech, and mastication are adversely affected in such situations, with consequent effects on the patient's quality of life. It is therefore imperative to include mandible reconstruction in the treatment plan.