Treatment Of Lichen Amyloidosis Research Articles

Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab: Four case reports

Lichen amyloidosis (LA) is a chronic, severely pruritic skin disease, which is the most common form of primary cutaneous amyloidosis. The treatment of LA has been considered to be difficult. LA may be associated with atopic dermatitis (AD), and in this setting, the treatment options may be more limited. Herein, we report four cases of LA associated with AD successfully treated by dupilumab. In this article, we describe four cases of patients who presented with recurrent skin rash accompanied by severe generalized intractable pruritus, diagnosed with refractory LA coexisting with chronic AD. Previous treatments had not produced any apparent improvement. Thus, we administered dupilumab injection subcutaneously at a dose of 600 mg for the first time and 300 mg every 2 wk thereafter. Their lesions all markedly improved. Dupilumab may be a new useful treatment for LA coexisting with AD.

Successful Treatment of Lichen Amyloidosis Using a Fixed Combination of Halobetasol-Propionate and Tazarotene Lotion

Successful Treatment of Lichen Amyloidosis Using a Fixed Combination of Halobetasol-Propionate and Tazarotene Lotion

Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases.

Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases.

Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels

Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels

An intensely pruritic pebbled presentation

Lichen amyloidosis (LA) is a form of primary localized cutaneous amyloidosis (PLCA) characterized by bilateral intensely itchy domed scaly hyperkeratotic papules. Lichen amyloidosis is rare and affects men more than women. It is uncommonly seen in the western world but more prevalent in Asia. These papules most typically affect the shins and occasionally the arms and torso. Lichen amyloidosis has been reported in association with autoimmune disorders and after prolonged exfoliation and friction of affected skin. We present a 40-year-old woman with LA. In LA, the characteristic histological finding is apple-green birefringence of Congo red-stained preparations observed under polarized light. However, this is not always strongly positive, as in our patient. Other findings may include eosinophilia, periodic acid-Schiff positivity, staining with thioflavin T, and metachromasia after staining with crystal violet or methyl violet. Treatment of LA is difficult and complete clinical remission is seldom achieved. Recent trials revealed beneficial outcomes with topical calcipotriol, phototherapy, acitretin, cyclophosphamide, and laser treatments. A combination of acitretin, antihistamines, topical steroids, and hydrocolloid dressings have been beneficial in our patient with LA.

Successful treatment of lichen amyloidosis using a CO2surgical laser

Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis characterized by multiple pruritic discrete hyperkeratotic papules with amyloid deposition in the papillary dermis. Two patients with LA had been treated with topical corticosteroids, but with no effect on the eruptions. The present authors then started treating the affected area by superficial ablation using a CO2 surgical laser (LASER 30C, Lumenis Inc., Yokneum, Israel) at a setting of 10-15 watts with a 0.12-second pulse duration, 0.36-second rest duration, and 5-mm laser spot size. The present authors treated the patients twice a month with the CO2 laser. The papules on the legs had flattened in both patients, with a great improvement in the severe itching after 6 months in Case 1 and after 10 months in Case 2. These cases indicate that the CO2 laser led to a good response in terms of the clinical manifestations, and may be useful for the treatment of LA.

Lichen amyloidosis: Novel treatment with fractional ablative 2,940 nm Erbium: YAG laser treatment

Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins and histopathologically characterized by amyloid deposits in the papillary dermis. The condition is difficult to treat though various treatment modalities have been tried. We report a case of LA treated successfully with Fractional ablative 2,940 nm Erbium: YAG Laser treatment. To the best of our knowledge, this is the first documented report of the successful use of fractional ablative laser in the treatment of LA.

Clinical effect of tocoretinate on lichen and macular amyloidosis

Lichen amyloidosis and macular amyloidosis are commonly therapy-resistant. Tocoretinate is a hybrid compound of retinoic acid and tocopherol that is commonly used for the treatment of skin ulcers. Although beneficial effect of oral retinoic acid on lichen amyloidosis is reported, tocoretinate has not been reported to be useful for the treatment of lichen amyloidosis or macular amyloidosis. We evaluated the effects of topical tocoretinate on lichen amyloidosis and macular amyloidosis lesions. Tocoretinate was topically applied daily to the lesions and clinical improvement and histological changes were evaluated. The outcome was very good for four, good for two, moderate for two and poor for two of 10 treated patients. Epidermal hypertrophy was reduced and expression of involucrin, keratin 1 and keratin 10 was decreased by tocoretinate treatment, suggesting the normalization of epidermal differentiation. Amyloid deposits remained histologically detectable, even in clinically responsive patients. Together, topical application of tocoretinate reduced the clinical symptoms of lichen amyloidosis and macular amyloidosis, and normalized disturbed epidermal differentiation.

Frequency-doubled Q-switched Nd:YAG laser in the treatment of lichen amyloidosis

Frequency-doubled Q-switched Nd:YAG laser in the treatment of lichen amyloidosis

The treatment of lichen amyloidosis. A review and a new technique.

A number of treatments for lichen amyloidosis have been described and the results are frequently unsatisfactory. To describe a new surgical technique that uses a scalpel to scrape the upper layer of the skin. A scalpel (No. 15) is pressed firmly and perpendicularly against the skin and scraped exactly parallel with the surface of the skin. This can be repeated until the subpapillary dermal layer. Scraping with the scalpel removes the epidermis and deposits of amyloid in the dermis. All nine patients healed without complications with acceptable to good aesthetic results. The technique is quick, effective, simple to perform, inexpensive, and safe. This is another option in the surgical treatment of selected cases of lichen amyloidosis.