Objective: To explore the rule of traditional Chinese medicine in the treatment of hysteromyoma, and provide theoretical basis for clinical medication and development of new drugs. Methods: In CNKI, with "hysteromyoma" and "traditional Chinese medicine" as the subject words, search the journal papers from January 2009 to July 2019, sort out the prescriptions of traditional Chinese medicine recorded in the literature, establish a database, and carry out statistical analysis. Using statistical software tools, such as Excel 2013, SPSS Modeler 14.1, SPSS Statistics 21, the frequency and types of Chinese medicine, association rules and association factors were analyzed. Results: 125 articles were included, involving 183 kinds of traditional Chinese medicine, and the total frequency was 1268.Among the 183 traditional Chinese medicines included, there are 55 kinds of traditional Chinese medicines with frequency ≥ 5, 29 kinds of traditional Chinese medicines with frequency ≥ 10. The first three medicines with the highest frequency are angelica, peach kernel and trigonometry; the most effective drugs are blood activating and stasis removing drugs, Qi regulating drugs, qi invigorating drugs and heat clearing and blood cooling drugs. In the taste of drugs, mainly sweet, bitter and pungent; in the meridian tropism, mainly liver, lung, heart and kidney. Among the association rules, 23 combinations with the highest Association intensity were found, and 8 common factors were extracted by factor analysis. Conclusion: in the clinical treatment of hysteromyoma, the drugs for promoting blood circulation and removing blood stasis are mainly used, and they are mostly combined with Qi regulating drugs.