Treatment Of Dermal Lesions Research Articles

Bacterial cellulose-based hydrogel for wound healing: characterization and in vitro evaluation

Bacterial cellulose (BC) has been considered a promising biopolymer with applications in several areas of knowledge, including medicine, mainly due to its ability to assist in the treatment of dermal lesions. Many groups and companies have been making efforts to develop new BC-based materials in order to add new characteristics and therapeutic possibilities. Recently, Seven Indústria de Produtos Biotecnológicos Ltda company developed a BC-based hydrogel aiming to verify the interaction among the formulation components, its potential for wound healing and biocompatibility studies. BC-based hydrogel was characterized and compared with pristine BC film. Physicochemical characterization includes rheological measurements, thermal analyses, field emission gun - scanning electron microscopy (FE-SEM) and in vitro cell migration. BC-based hydrogel showed adequate interaction among the components of the formulation, which may positively influence its stability. In addition, the BC-based hydrogel accelerated the healing processes demonstrating its potential in dermal lesion treatment.

Development of bioresorbable bilayered systems for application as affordable wound dressings

The objective of this work was the preparation and evaluation of a bioresorbable bilayered system for application in the treatment of dermal lesions. The system was based on a polyesterurethane as the external layer and a gelatin membrane as the internal layer. The polyesterurethane was synthesized from poly(ε-caprolactone), polyethylene glycol of 1 or 10 kDa as a hydrophilic component or Pluronic F127 as an amphiphilic component and l-lysine ethyl ester diisocyanate as an urethane precursor. Gelatin membrane was obtained by crosslinking with the naturally occurring crosslinker genipin. Three important points were addressed in this study: the physicochemical characterization of the system, the in vitro behaviour and the in vivo performance on a full-thickness wound defect of rat. The polyesterurethane containing polyethylene glycol of 10 kDa presented the optimum properties for the designed application as to be tested in animal experiments. The in vivo results showed good healing of the lesion with the formation of epidermis similar to normal rat skin. These promising results suggest the potential of this system to be used as an affordable wound dressing in the treatment of different dermal lesions.

Successful Treatment of Dermal Lesions in the Microhylid Frog, Scaphiophryne gottlebei

Successful Treatment of Dermal Lesions in the Microhylid Frog, Scaphiophryne gottlebei

Diseases of the Skin

This volume comprises a broad survey of dermatology. The initial chapters pertain to the anatomy and physiology of the normal skin, allergic and hypersensitivity phenomena, basic pathological changes, and the principles of the diagnosis and treatment of dermal lesions. The following chapters classify skin disorders in an orderly fashion. The disease entities peculiar to the skin are discussed as well as the numerous diseases and disorders involving other organ systems which have dermal manifestations. The diseases of the epidermal appendages and the buccal and genital mucosa are also covered. Dermatological lesions are discussed with respect to the etiology, incidence, and appearance of the various stages of their evolution. This is followed by a discussion of the histopathology and treatment of the lesion. The coverage of each subject is written in a concise manner. Numerous photographs help to clarify the text. Emphasis is placed on the more common dermal lesions, whereas