Background Diabetes mellitus is a chronic disease that affects several hundred million people. In the presence of type 1 diabetes mellitus, there is a xerostomia, a violation of microcirculation, epithelial regeneration, a change in local immunity, the accumulation of glycated hemoglobin, which disrupts the supply of nutrients, and reduces the resistance of tissues to the action of foreign microorganisms, leading to the formation of a hard-to-treat chronic mechanical injury of the oral mucosa. Objectives Conduct an analysis of the efficacy of the complex treatment for chronic mechanical trauma of the oral mucosa in patients with type 1 diabetes based on clinical, dental, immunological, sociological research methods and functional vascular studies. Methods The dental, clinical status, overall quality of life, local immunological status and hemodynamics of the oral mucosa before and after treatment of chronic injuries of the oral mucosa in patients with type 1 diabetes mellitus by the traditional method compared with the scheme developed by us. Results As a result of the study, the success of treatment of chronic injuries of the oral mucosa in patients with type 1 diabetes according to our method is more effective than traditional treatment: by 20 % in terms of dental status, clinical symptoms and cytokine profile; complete disappearance of inflammatory changes in the oral mucosa 50 % improved the quality of life; the condition of the microcirculatory channel of the oral mucosa reached the figures of the control group. Conclusions With the application of the method of treatment of chronic mechanical trauma proposed by us in patients with type 1 diabetes mellitus using the Optotan physiotherapeutic laser apparatus with 5 % of mexidol and Ozonid oil, the therapy proved highly effective, based on the results of the study.
Read full abstract